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1/6. lymphogranuloma venereum in human immunodeficiency virus-infected individuals in new york city.

    lymphogranuloma venereum (LGV), or chlamydial proctitis, is a classic sexually transmitted disease with prominent gastrointestinal manifestations. The disease has received little attention in recent years, especially in relation to human immunodeficiency virus (hiv) infection. However, outbreaks of LGV have been reported in several large cities in europe and the united states over the past few years, occurring in both hiv-infected and -uninfected individuals, and the reports have been largely limited to the sexually transmitted disease literature. We recently diagnosed four cases of chlamydial proctitis in hiv-infected individuals, who had different clinical presentations but very similar endoscopic and histopathologic features, as well as prompt and complete response to therapy. It is important for gastroenterologists to recognize that LGV may be reemerging as a relevant clinical entity, because of its similarity to inflammatory bowel diseases and its response to treatment with antibiotics.
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ranking = 1
keywords = proctitis
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2/6. Sexually transmitted cytomegalovirus proctitis in a woman.

    A heterosexual woman with cytomegalovirus (CMV) proctitis after anal intercourse is presented. Whereas CMV infection typically occurs in immunosuppressed patients, including patients with acquired immune deficiency syndrome (AIDS), this patient has no evidence of immunodeficiency, and is human immunodeficiency virus (hiv) negative during 8 months of follow-up since onset of proctitis. A review of the literature reveals no other report of sexually transmitted CMV proctitis in an immunocompetent woman after anal intercourse.
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ranking = 3.5
keywords = proctitis
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3/6. opportunistic infections and immune deficiency in homosexual men.

    A syndrome of opportunistic infections and acquired immune deficiency occurred among four previously healthy homosexual men. fever, leukopenia, and diminished delayed hypersensitivity were accompanied by various degrees of proctitis, perianal ulcerations, and lymphadenopathy. The infectious agents included pneumocystis carinii, cryptococcus neoformans, candida albicans, herpes simplex virus, and cytomegalovirus. The immune deficiency was characterized as a persistent and profound selective decrease in the function as well as number of T lymphocytes of the helper/inducer subset and a possible activation of the suppressor/cytotoxic subset. Three patients died despite aggressive anti-infective therapy.
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ranking = 0.5
keywords = proctitis
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4/6. Isolation of neisseria meningitidis from anogenital sites in adolescents: clinical implications.

    neisseria meningitidis is being increasingly isolated from the urethra, cervix, and anal canal of sexually active individuals. We found a similar phenomenon in inner-city black and Hispanic adolescents. In 1981, cultures of 92 isolates of Neisseria were made from the anogenital region of sexually active adolescents; 81 (88.0%) were N. gonorrhoeae, 3 (3.3%) could not be speciated, and 8 (8.7%) were N. meningitidis. Since N. meningitidis has been associated with urethritis and pelvic inflammatory disease, it should be considered a pathogen when identified in the urethra or cervix and should be appropriately treated. The health implications of isolating N. meningitidis from the anal canal are less clear, although it has been rarely associated with proctitis. Neisseria isolates from anogenital sites cannot be assumed to be gonococci and, therefore, should be distinguished from N. meningitidis.
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ranking = 0.5
keywords = proctitis
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5/6. Radiographic findings of infectious proctitis in homosexual men.

    Homosexual men are known to have an increased incidence of sexually transmitted proctitis. A knowledge of the pathogenesis and the radiographic appearance of these processes has resulted in earlier diagnosis and more rapid institution of appropriate therapy. While gonococcus (neisseria gonorrhoeae) and lymphogranuloma venereum (usually Chlamydia) have long been considered the common etiologies of proctitis in this population, other organisms, such as herpes, mycoplasma, and entamoeba have been implicated and could give an identical radiographic and clinical pattern. Diffuse narrowing and ulceration limited to the rectum was seen in five affected homosexual men recently studied at Northwestern Memorial Hospital, chicago.
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ranking = 3
keywords = proctitis
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6/6. The gay bowel syndrome: clinico-pathologic correlation in 260 cases.

    The clinical and pathological findings in a group of 260 homosexual men comprising 10% of a private proctologic practice are reviewed. A clinical pattern of anorectal and colon diseases encountered with unusual frequency in these homosexual patients is termed the gay bowel syndrome. The clinical diagnoses in decreasing order of frequency include condyloma acuminata, hemorrhoids, nonspecific proctitis, anal fistula, perirectal abscess, anal fissure, amebiasis, benign polyps, viral hepatitis, gonorrhea, syphilis, anorectal trauma and foreign bodies, shigellosis, rectal ulcers and lymphogranuloma venereum. 60 anorectal and sigmoid biopsies from 51 patients failed to disclose evidence of specific infection other than condyloma acuminata. Of 21 patients with biopsy diagnosis of nonspecific proctitis, 8 had a specific infection which was detected by other means,--5 cases of shigellosis and one case each of gonorrheal proctitis, amebiasis and lymphogranuloma venereum. In evaluating proctologic problems in the gay male, all of the known sexually transmitted diseases should be considered. Shigellosis, amebiasis and viral hepatitis should be included. Microbiological evaluation is essential. Concurrent infections with 2 or more pathogens should be anticipated. chlamydia trachomatis, an important cause of nonspecific urethritis in the general population, is high on the list of possible causes of the nonspecific proctitis present in 31 of the 260 patients.
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ranking = 2
keywords = proctitis
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