Cases reported "Sinusitis"

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1/3. Case report. Successful outcome of invasive nasal sinus zygomycosis in a child with relapsed acute lymphoblastic leukaemia due to liposomal amphotericin b.

    We report a case of life-threatening nasal sinus zygomycosis that developed during remission induction therapy for a relapsed acute lymphoblastic leukaemia. The patient was successfully treated with liposomal amphotericin b and granulocyte-colony stimulating factor followed by surgical reconstruction of the resultant cutaneous defect.
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ranking = 1
keywords = zygomycosis
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2/3. Surgery and treatment with high-dose liposomal amphotericin b for eradication of craniofacial zygomycosis in a patient with Hodgkin's disease who had undergone allogeneic hematopoietic stem cell transplantation.

    This case report describes craniofacial zygomycosis in a 24-year-old male with Hodgkin's disease who underwent chemotherapy and autologous hematopoietic stem cell transplantation, followed by a nonmyeloablative allogeneic transplant. Empirical therapy with itraconazole and amoxicillin-clavulanate failed to resolve the infection. Postdiagnosis, surgery and treatment with high-dose liposomal amphotericin b eradicated the disease.
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ranking = 1
keywords = zygomycosis
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3/3. Successful treatment of rhinocerebral zygomycosis with a combination of caspofungin and liposomal amphotericin b.

    Genera of the order mucorales (rhizopus, Mucor, rhizomucor, absidia, Apophysomyces, cunninghamella, and Saksenaea) cause an angioinvasive infection called zygomycosis. mortality rates can approach 100% depending on the patient's underlying disease and form of zygomycosis. We report here on the unusual case of a patient with acute myelogenous leukemia and zygomycosis unresponsive to monotherapy with liposomal amphotericin b, who responded favorably following the addition of the echinocandin caspofungin acetate.
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ranking = 1.4
keywords = zygomycosis
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