Cases reported "Skin Ulcer"

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1/5. Ultraviolet light C in the treatment of chronic wounds with MRSA: a case study.

    The prevalence of antibiotic-resistant bacteria such as methicillin-resistant staphylococcus aureus is rapidly increasing in healthcare facilities and spreading to the community. Methicillin-resistant S. aureus colonize the skin and open wounds and can interfere with wound healing. Recent studies have shown that ultraviolet light C can kill antibiotic-resistant strains of bacteria such as methicillin-resistant S. aureus in both laboratory cultures and animal tissue. This clinical report describes the effects of ultraviolet light C on wound bioburden and closure in three people with chronic ulcers infected with methicillin-resistant S. aureus. In all three patients, ultraviolet light C treatment reduced wound bioburden and facilitated wound healing. Two patients had complete wound closure following 1 week of ultraviolet light C treatment. This case study suggests that ultraviolet light C is a promising adjunctive therapy for chronic wounds containing antibiotic-resistant bacteria such as methicillin-resistant S. aureus.
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keywords = animal
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2/5. Penile ulcer from traumatic orogenital contact.

    Human bite injuries, although less frequent than animal bites, usually stem from aggressive behavior, sports participation, or sexual activity. Human genital bites and similar traumatic events also occur, but are infrequently reported because of embarrassment. A genital ulceration following mild trauma during oral-genital contact is reported and appropriate diagnostic and therapeutic interventions reviewed. The ulcer was infected, as verified by culture, with an aggressive oral flora organism, eikenella corrodens. The genital ulceration healed following appropriate antibiotic therapy. Treatment of human bites focuses on obtaining an accurate history and salient physical examination, as well as performing early irrigation and debridement. Prophylactic antibiotic treatment and primary closure of bite wounds remain areas of controversy. Because there is an inherent high risk of infection, genital human bite wounds (and similar traumatic events related to orogenital contact) should be managed with prophylactic antibiotic administration.
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ranking = 1
keywords = animal
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3/5. Efficacy of a skin-protection powder for use as a dressing for intractable ulcers.

    OBJECTIVE: Stomahesive skin-protection powder has been reported to be useful as a skin-care and skin-barrier product for the management of stomas.This study aimed to evaluate its efficacy, in terms of wound healing, moisture retention and pain management, as an alternative to conventional dressing materials. Both clinical and animal studies were undertaken. METHOD: The efficacy of the Stomahesive powder was tested by measuring the thickness of granulation tissue formed in a total skin defect in a db/db mouse model. We then compared the healing process using either the skin-protection powder or a conventional film dressing material. In the clinical study 17 patients with various intractable ulcers were treated with Stomahesive powder, and healing was evaluated. RESULTS: In the mouse model, granulation tissue in the wounds treated with the powder was 2.86 times thicker than that of the wounds treated with the film dressing. In the clinical study, 16 out of 17 wounds healed completely. CONCLUSION: The Stomahesive powder could be an effective treatment modality for contact ulceration, superficial ulcers with complex contours and morphology, and superficial ulcers contaminated by liquid faeces or vaginal discharge that have not responded to conventional dressings. Declaration of interest: None.
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ranking = 1
keywords = animal
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4/5. Minimal surgical debridement for the treatment of chemotherapeutic agent-induced skin extravasations.

    A rat model was employed to determine the efficacy of early minimal debridement in decreasing the size of chemotherapeutic agent-induced skin ulcers. After receiving bilateral flank injections of doxorubicin in a concentration comparable to that received by humans, the right injection site underwent minimal debridement 1, 24, or 72 hours after the injection. The left side of each animal was not operated upon and served as a control. Three subgroups of the 1-, 24-, and 72-hour debridement groups were treated as previously described, except that any residual necrotic tissue was debrided 1 week after the original debridement. All minimal debridement and redebridement groups produced significant decreases in ulcer size compared to controls. Comparing minimal debridement and redebridement groups to controls, it was found that surgery produced reductions in the number of persistent ulcers in all groups. Minimal debridement followed by redebridement was significantly more effective than minimal debridement alone in decreasing ulcer size acutely. One case is presented in which an extravasation of dactinomycin was treated by early minimal debridement. The patient had an uncomplicated postoperative course, and at follow-up 21 months after surgery had excellent functional and cosmetic results. Based upon animal studies and human experience, early surgical debridement appears to be a promising new method for the treatment of clinically significant vesicant extravasations in humans.
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ranking = 2
keywords = animal
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5/5. skin grafting herpetic ulcers.

    Recurrent and chronic herpetic skin ulcers are associated with the persistence of virus in the dorsal root ganglia serving the respective dermatomes. Descriptions of surgical approaches to control herpetic skin disease have recently appeared in the medical literature. We report the successful excision and skin grafting of chronic genital ulcers. Our subsequent animal studies support our expectations that potential seeding and reinfection of the grafted skin can occur following graft reinnervation. This problem must be watched for following grafts of herpetic ulcers in humans.
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ranking = 1
keywords = animal
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