Cases reported "Skin Ulcer"

Filter by keywords:



Filtering documents. Please wait...

11/12. Disseminated American cutaneous leishmaniasis.

    BACKGROUND: While studying cutaneous leishmaniasis in the central part of western venezuela, we found four cases of disseminated American cutaneous leishmaniasis, three from the Lara State and one from Portuguesa State. methods: A clinical history was taken for each of these patients, followed by microscopic examination of the Giemsastained smears from their cutaneous lesions and by a montenegro skin test. serum from a skin lesion were grown in Novy-MacNeal-Nicolle medium (NNN). Hamsters were inoculated with suspension of tissues taken from the patient's lesions. Biopsies were taken for histopathologic examination. Isolates from cultures on NNN medium and from hamsters were subcultured in Schneider's medium for parasite identification, using molecular techniques. Treatment with injections of N-methyl glucamine antimonate, 25 mg/kg/day was prescribed for each patient for 20 consecutive days and, after a week of rest, a second course of injections was administered. RESULTS: patients had disseminated papular, ulcerous, nodular, and ulceronodular lesions on the skin. Smears of the skin lesions from all of the patients showed abundant amastigotes within histiocytes or free in the tissues. The skin test was negative in two patients. On histopathologic examination of skin lesions, mainly numerous vacuolated histiocytes filled with amastigotes were observed. Isolates from all the patients were identified as Leishmania venezuelensis. One of the patients healed after treatment with N-methyl glucamine antimonate. The others were resistant to this therapy. CONCLUSIONS: Diffuse cutaneous leishmaniasis can be caused also by Leishmania venezuelensis. patients with nodular lesions who presented a negative montenegro skin test were more resistant to treatment with specific pentavalent antimonials.
- - - - - - - - - -
ranking = 1
keywords = leishmaniasis
(Clic here for more details about this article)

12/12. Imported mucocutaneous leishmaniasis.

    We report a case of mucocutaneous leishmaniasis in a otherwise fit Caucasian man who had traveled in an endemic area. Initial tissue microscopy failed to identify the causative organism, which was only determined by subsequent culture as leishmania braziliensis. This case illustrates the variability in the presence of Leishman-Donovan (LD) bodies in histopathological studies and emphasizes the need for culture in suspected cases of leishmaniasis, particularly given the ability of certain Leishmania species such as L. braziliensis to cause recalcitrant and destructive infections of the nose and mouth.
- - - - - - - - - -
ranking = 0.85714285714286
keywords = leishmaniasis
(Clic here for more details about this article)
<- Previous |


Leave a message about 'Skin Ulcer'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.