Cases reported "Splenic Rupture"

Filter by keywords:



Filtering documents. Please wait...

1/4. Ischemic stroke and splenic rupture in a case of streptococcus bovis endocarditis.

    A 58-year-old man with an acute stroke suffered from splenic rupture. streptococcus bovis was found in blood cultures, and gram-negative cocci were found in the infarcted spleen. Hemorrhagic transformation of the stroke occurred. echocardiography showed aortic endocarditis. Cardiac surgery was not performed because of concern about cerebral bleeding. The patient died due to cerebral rehemorrhage after 3 weeks.
- - - - - - - - - -
ranking = 1
keywords = culture
(Clic here for more details about this article)

2/4. Chronic myeloid leukemia: manifesting as spontaneous splenic rupture and terminating in megakaryoblastic transformation.

    We report a case of chronic myeloid leukemia with spontaneous splenic rupture as the initial presenting feature; there was a successful surgical outcome, but this case terminated in megakaryoblastic transformation. Results are reported based on morphological, immunological, cytochemical, ultrastructural, immunocytochemical studies, and in vitro liquid culture studies. The megakaryocytic nature of the blast cells was identified through the demonstration of platelet peroxidase activity by ultrastructural cytochemistry and the presence of platelet and megakaryocyte-specific antigen using monoclonal antibody, as well as the anti-factor viii antibody by immunocytochemical technique.
- - - - - - - - - -
ranking = 1
keywords = culture
(Clic here for more details about this article)

3/4. Pathologic rupture of the spleen due to salmonella dublin infection.

    A case of salmonella dublin infection presenting as pathologic rupture of the spleen is reported. Because the incidence of salmonellosis is increasing, the importance of operative and tissue cultures in cases with subcapsular splenic hemorrhage and splenic rupture is stressed. cephalosporins will be ineffective in salmonellosis, which should be treated with chloramphenicol, ampicillin, or sulfamethoxizole-trimethoprim.
- - - - - - - - - -
ranking = 1
keywords = culture
(Clic here for more details about this article)

4/4. Fatal spleen rupture during induction chemotherapy with rh GM-CSF priming for acute monocytic leukemia. Clinical case report and in vitro studies.

    Recombinant human (rh) granulocyte-macrophage colony-stimulating factor (GM-SCF) is currently being tested in clinical trials for the treatment of acute myeloid leukemias with two main intentions: reduction of neutropenia and recruitment of leukemic blasts into cell cycle to enhance cytarabine (ara-C) mediated cytotoxicity. We report a case of a fatal spleen rupture in a patient with acute monocytic leukemia (AML M5b) who was treated according to a clinical phase I/II protocol with rh GM-CSF priming and standard induction chemotherapy TAD 9 (thioguanine/ara-C/daunorubicin). During treatment we observed rapidly rising peripheral blast counts and the development of an acute abdomen. Ultrasound examination revealed splenomegaly due to diffuse cellular infiltration and spleen rupture. The patient died 17 days later due to pneumonia and renewed spleen hemorrhage. bone marrow progenitor assays before treatment showed exclusive growth of monocytoid blast cell colonies (CFU-L). Colony growth could be stimulated with rh GM-CSF and blocked dose-dependently by a monoclonal anti-GM-CSF antibody. CFU-L proliferation also increased after stimulation with rh interleukin-3 (rh IL-3) and supra-additively with rh granulocyte colony-stimulating factor (rh G-CSF) combined with rh GM-CSF. Furthermore, rh GM-CSF induced surface marker expression of CDw 65 and CD 11b on isolated CFU-L blasts. After short-term suspension culture, rh GM-CSF enhanced the expression of CD 29- and CD 11b-adhesion molecules on peripheral blast cells. In summary, this case represents a fatal spleen rupture occurring during rh GM-CSF priming and induction chemotherapy for acute monocytic leukemia. Although the etiology of this spleen rupture remains uncertain, in view of our data we suggest special caution, when further testing this therapy protocol in acute leukemias with monocytic subtype and high peripheral blast cell counts.
- - - - - - - - - -
ranking = 1
keywords = culture
(Clic here for more details about this article)


Leave a message about 'Splenic Rupture'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.