Cases reported "Testicular Diseases"

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11/22. Nuclear bodies (sphaeridia) in sertoli cells of a man with acquired immunodeficiency syndrome (AIDS) and testicular infection by cytomegalovirus.

    Histological and ultrastructural study of an adult man with acquired immunodeficiency syndrome (AIDS) revealed multiple testicular lesions. The seminiferous tubules varied from dilated tubules with hypospermatogenesis, to tubules with sertoli cells and a few spermatogonia, to necrotic tubules. The testicular interstitium showed abundant inflammatory infiltrates, some of them forming microabscesses. The sertoli cells exhibited spherical intranuclear inclusions corresponding to both cytomegalovirus and sphaeridia. Some sphaeridia stained intensely with EDTA as granular and fibrillar portions of the nucleolus; however, many sphaeridia stained weakly as nucleolar fibrillar centers. These observations suggest that a Sertoli cell response to cytomegalovirus is the proliferation of nucleolar organizing centers that in some instances may transform to give rise to more or less abnormally developed nucleoli.
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ranking = 1
keywords = seminiferous tubule, tubule
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12/22. Sonography of testicular microlithiasis.

    The sonographic appearance of testicular microlithiasis detected in a patient presenting with torsion is described. A "speckled" pattern of multiple, tiny bright echoes is produced by calcific concretions in the seminiferous tubules and seems to be characteristic of microlithiasis. Although this condition is not treatable, it should be recognized because it is often associated with extratesticular abnormalities and can obscure superimposed testicular disease.
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ranking = 0.99294530255369
keywords = seminiferous tubule, tubule
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13/22. cysts of the testicular parenchyma and tunica albuginea.

    Five cases of cysts of the tunica albuginea and two cases of cysts of the testicular parenchyma are described. The cysts of the albuginea were located in the anterior, lateral, and inferior faces of the testis (distant from the epididymis) and covered by a thin albuginea. They extended toward the testicular parenchyma or toward the tunica vaginalis. Their epithelial lining varied from low cuboidal to columnar and consisted of ciliated or nonciliated cells. These cysts were probably of mesothelial origin. The cysts of the testicular parenchyma were also located distant from the mediastinum testis and were not in contact with the albuginea. Their epithelial lining consisted of flattened, cuboidal, nonciliated cells. The origin of the cysts of the testicular parenchyma is not clear. In one case the occurrence of spermatozoa in the cyst lumen and connections with seminiferous tubules suggests an origin in the rete testis.
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ranking = 0.99294530255369
keywords = seminiferous tubule, tubule
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14/22. Nodular proliferation of calcifying connective tissue in the rete testis: a study of three cases.

    We report the first description of a bilateral rete testis lesion. The lesion was found in three adult men with histories of myocardium infarct or hemorrhage. The histologic study of the rete testis in these men revealed nodular sessile or pediculate formations which protruded into the rete testis channels. These polypoid formations consisted of an axis of connective tissue covered by a flattened epithelium. The axis contained a variable number of fibroblasts, areas with fibrin-like material, and small to large calcium deposits. Inflammatory infiltrates were neither observed in the rete testis nor in the testicular parenchyma. The testicular pattern varied from seminiferous tubules with complete spermatogenesis (two cases) to tubules with sertoli cells and a few spermatogonia, surrounded by a thickened tunica propia. The term "nodular proliferation of calcifying connective tissue in the rete testis" is proposed to designate this lesion.
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ranking = 0.99529686836912
keywords = seminiferous tubule, tubule
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15/22. Testicular microlithiasis in 2 children with bilateral cryptorchidism.

    Testicular microlithiasis, associated with bilateral cryptorchidism, is studied in 2, 6-year-old children. In case 1 autopsy revealed that 60 per cent of the seminiferous tubules contained completely calcified microliths. Similar mineralized concretions also were found in different areas of the cerebrum and cerebellum. In the testicular biopsy obtained from case 2, 30 per cent of the seminiferous tubules contained microliths showing different degrees of calcification. The study of such calcifications supports the hypothesis that the mineralization process occurs according to the following stages: 1) accumulation of cellular debris in the tubular lumen, 2) deposit of concentric rings of glycoprotein material surrounding the central core and 3) calcification of the glycoprotein lamellar material. The presence of similar concretion in the nervous system as well as the lung in other reported cases suggests that microlithiasis could be a systemic disease.
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ranking = 1.9858906051074
keywords = seminiferous tubule, tubule
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16/22. Pseudocysts of the tunica albuginea: benign invasion by testicular tubules.

    We describe a patient undergoing exploration for an epididymectomy in whom a unique apparently multicystic lesion of the testis resulted in orchiectomy. On microscopic examination the lesion was proved to be a benign, previously unreported condition wherein the tunica albuginea was split by an invasion of testicular tubules. We postulate that this condition is a developmental anomaly.
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ranking = 0.011757829077189
keywords = tubule
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17/22. Testicular lymphangiectasis in Noonan's syndrome.

    We describe a boy with testicular lymphangiectasis and Noonan's syndrome. Both testes showed seminiferous tubules with a reduced tubular diameter, containing few spermatogonia. The testicular interstitium exhibited a number of large, dilated lymphatic vessels forming irregular channels among the seminiferous tubules and surrounding them. Since there was no accompanying pathological condition to indicate an obstruction to the lymphatic flow at the level of the spermatic cord or in the regional lymph nodes, the abnormal development of testicular lymphatic vessels suggests a congenital malformation.
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ranking = 1.9858906051074
keywords = seminiferous tubule, tubule
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18/22. Simple testicular cyst in the neonate.

    The authors report the first case of a simple testicular cyst presenting in a neonate. Diagnostic criteria are outlined and theories concerning etiology are discussed. The authors show an absence of elastin staining in the specimen, and suggest this precludes germinal tubules as a source. The rationale for testicular-sparing surgery is discussed.
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ranking = 0.0023515658154378
keywords = tubule
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19/22. Cystic dysplasia of the testis.

    Cystic dysplasia of the testis (CDT) is a rare congenital defect that results in the formation of numerous irregular cystic spaces within the mediastinum testis. We describe a 4-year-old boy with right testicular swelling who underwent orchiectomy for CDT after a preoperative ultrasound examination revealed a multicystic, anechoic lesion. Grossly, the lesion was 2 cm in size and was composed of multiple, irregularly shaped cystic spaces lined by flattened cuboidal epithelium. Immunohistochemical studies revealed that the epithelial cells expressed keratin, vimentin, and epithelial membrane antigen. Both the histologic appearance of the cyst lining and the immunohistochemical profile resembled the epithelium of rete testis. In our review of the literature 10 cases (including this lesion) of CDT have been described. A defect in the connection between the efferent ductules, derived from the mesonephric epithelium, and the rete testis and seminiferous tubules, derived from the gonadal blastema, is currently thought to be the most likely explanation of the pathogenesis of CDT.
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ranking = 0.99294530255369
keywords = seminiferous tubule, tubule
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20/22. Pathological changes of traumatic dislocated testis.

    We present a 17-year-old patient with a right testicular dislocation. In this case, dislocated testis had been considered as hematoma and therefore remained untreated for 4 months. The patient underwent right orchiopexy 4 months after the injury. Intraoperative testicular biopsy revealed impaired spermatogenesis and existence of many alternative sertoli cells, but no atrophy of seminiferous tubules. Six months after the operation, semen analysis of the patient revealed the deformity of most sperms. Eight months after the operation, rebiopsy of the right testis disclosed slight improvement in the spermatogenesis of the testis. Damage of the testis appears to be not severe in dislocation and may be recovered by repositioning.
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ranking = 0.99294530255369
keywords = seminiferous tubule, tubule
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