Cases reported "Thrombosis"

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11/131. A giant left ventricular thrombus in a patient with acute myocardial infarction--a case report.

    The authors report a patient with acute anteroseptal myocardial infarction with a giant left ventricular thrombus at the apex. The patient also had nephrotic syndrome due to diabetic nephropathy. coronary angiography showed 90% stenosis at segment 6 of the left anterior descending coronary artery. Percutaneous transluminal coronary angioplasty and intracoronary stenting were performed on the 30th day, and effective coronary blood flow was obtained. heparin was injected intravenously for the first 7 days, and warfarin was administered thereafter. The left ventricular thrombus disappeared after 46 days. No evidence of arterial thromboembolism was found during the disappearance of the left ventricular thrombus as determined by echocardiography.
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ranking = 1
keywords = thromboembolism
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12/131. factor v Leiden mutation in Turkish patients with homozygous cystathionine beta-synthase deficiency.

    Venous and arterial thromboembolism can occur in patients with homocystinuria. Resistance to activated protein c, which is caused by a single point mutation in the gene for factor v, renders an individual at risk for thrombosis. It has been suggested that coexistence of hereditary homocystinuria and factor v Leiden mutation might jointly play a role in the development of thrombosis. We analysed six patients with homocystinuria due to cystathionine beta-synthase deficiency for factor v Leiden and prothrombin G20210A mutations. Only one patient was found to have the factor v Leiden mutation in homozygous form and this patient had suffered from severe thrombosis. One patient was found to be heterozygous with no documented thrombosis. None of the patients had prothrombin G20210A mutation. We stress the necessity for screening for known thrombophilic risk factors in patients with cystathonine beta-synthase deficiency. The coexistence of the factor v Leiden mutation can cause severe thrombotic events in patients with homocystinuria.
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ranking = 1
keywords = thromboembolism
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13/131. Management of pregnancy with congenital antithrombin iii deficiency: two case reports and a review of the literature.

    women with antithrombin (AT) III deficiency are prone to pregnancy-associated venous thromboembolism. We report 2 cases with genetically confirmed ATIII deficiency, one with a mutation in exon 3A and the other with an exon 4 deletion, in whom the pregnancies were successfully managed with prophylactic therapies for thrombosis. A 35-year-old pregnant woman was treated with intravenous infusions of ATIII concentrate alone, and the other 22-year-old pregnant woman was mainly treated with subcutaneous injections of heparin and oral low-dose aspirin therapy. Both pregnancies resulted in vaginal deliveries of healthy neonates. The literature concerning prophylactic therapies for thrombosis in ATIII deficiency-complicated pregnancy is reviewed, and the clinical problems, including the adverse effects of the therapies, are discussed.
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ranking = 1.3222020683066
keywords = thromboembolism, venous thromboembolism
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14/131. Hemorrhagic complication of anticoagulation during pregnancy in a woman with lupus anticoagulant.

    BACKGROUND: Lupus anticoagulant is an acquired antiphospholipid antibody that can increase greatly the risk of thromboembolism during pregnancy. Because a baseline elevated activated partial thromboplastin time (PTT) is associated frequently with this antibody, monitoring anticoagulant effect with activated PTT can be unreliable. CASE: A pregnant woman with lupus anticoagulant being treated with adjusted dose heparin experienced concurrent severe thrombotic and hemorrhagic complications. CONCLUSION: This case illustrates the pitfall of activated PTT monitoring when administering anticoagulation therapy to a patient with a baseline elevated activated PTT. We propose that heparin levels be used to monitor anticoagulation in these patients.
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ranking = 1
keywords = thromboembolism
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15/131. Percutaneous cardiopulmonary support for the treatment of right ventricular thrombus.

    The management of patients with acute pulmonary embolism (PE) remains controversial, despite an improved understanding of its pathogenesis and diagnosis. Haemodynamic instability due to right ventricular failure and hypoxia following PE is associated with a high mortality rate. This report describes a case of a 22-year-old woman with leukaemia in which percutaneous cardiopulmonary support (PCPS) was used as an adjunct to thrombolytic therapy in the treatment of right ventricular thrombus with acute PE. The patient has since undergone regular follow-up on an outpatient basis without showing any recurrence of thromboembolism at 2 years postoperatively. This experience suggests that supportive PCPS may provide favourable clinical outcomes in high-risk patients with severe PE.
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ranking = 1
keywords = thromboembolism
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16/131. Acute abdomen during adjuvant chemotherapy: superior mesenteric artery thrombosis associated with CMF chemotherapy.

    We report a case of superior mesenteric artery thrombosis in a 57-year-old woman undergoing chemotherapy for T1N1M0, breast cancer. Although cancer itself is associated with an increased risk of thrombotic events, treatment with chemotherapy and/or tamoxifen in breast cancer patients increases this risk. Most cases reported are of venous thromboembolism; arterial events are rare.
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ranking = 1.3222020683066
keywords = thromboembolism, venous thromboembolism
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17/131. Huge left atrial thrombus with mitral stenosis in congenital factor xii deficiency.

    factor xii deficiency has been reported to be a risk factor for thromboembolism as a result of inactivation of fibrinolysis. We describe a case of a huge left atrial thrombus with mitral stenosis, which was successfully removed surgically in a Factor XII deficient patient.
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ranking = 1
keywords = thromboembolism
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18/131. Large thrombus in the pulmonary arteries in a case of atrial septal defect-Eisenmenger syndrome.

    A 41-year-old man with atrial septal defect-Eisenmenger syndrome presented with progressively worsening breathlessness. The echocardiogram, computerized tomographic scan and magnetic resonance imaging of the thorax showed dilated pulmonary arteries and large thrombi in the right and left pulmonary arteries. Contrast-enhanced computerized tomographic scan was better than magnetic resonance imaging in picking up the thrombus. The possibility of in situ thrombus formation was considered more likely than thromboembolism, as there were none of the acute symptoms expected with the embolization of such large thrombi.
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ranking = 1
keywords = thromboembolism
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19/131. Treatment of right heart thromboemboli.

    BACKGROUND: The presence of right heart thromboemboli complicating pulmonary thromboemboli carries with it an increased mortality rate compared to pulmonary thromboemboli alone, but little is known about the optimal management of this difficult clinical situation. This fact is highlighted in the case study of a patient with a 19-cm right atrial thrombus complicating bilateral pulmonary thromboemboli. STUDY OBJECTIVES: We sought to determine the effects of anticoagulation therapy, thrombolysis, and surgical embolectomy on mortality rate in patients with right heart thromboemboli. DESIGN: Retrospective analysis of all reported cases in the English language literature (1966 to 2000) of right heart thromboembolism in which age, sex, therapy, and outcome were reported. MEASUREMENTS AND RESULTS: We analyzed 177 cases of right heart thromboembolism. Pulmonary thromboembolism was present in 98% of the cases. The patients were evenly divided by gender with an average age of 59.8 years (SD, 16.6 years) years. dyspnea (54.2%), chest pain (22.6%), and syncope (17.5%) were the most common presenting symptoms. The treatments administered were none (9%), anticoagulation therapy (35.0%), surgical procedure (35.6%), or thrombolytic therapy (19.8%). The overall mortality rate was 27.1%. The mortality rate associated with no therapy, anticoagulation therapy, surgical embolectomy, and thrombolysis was 100.0%, 28.6%, 23.8%, and 11.3%, respectively. Using multivariate modeling with survival as the primary outcome, age and gender were not associated with mortality rate, but thrombolytic therapy was associated with an improved survival rate (p < 0.05) when compared either to anticoagulation therapy or surgery. CONCLUSION: The presence of right heart thromboemboli may have diagnostic and therapeutic implications in pulmonary thromboembolism patients. A well-designed prospective, randomized trial is needed to determine the optimal treatment of right heart thromboemboli.
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ranking = 4
keywords = thromboembolism
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20/131. Sideroblastic anemia with splenic abscess and fatal thromboemboli after splenectomy.

    A man with sideroblastic anemia had a splenectomy because of a salmonella abscess of the spleen that had ruptured into the colon. Two months later he developed recurrent thrombophiebitis and fatal thromboembolism associated with thrombocytosis. A review of the literature showed multiple additional cases of sideroblastic anemia with thrombocytosis and thromboembolism after splenectomy. In many of these cases the patient died. splenectomy for treatment of a sideroblastic anemia probable is contraindicated. If splenectomy is done, long-term therapy to avoid thromboembolic complications probably should be maintained for many months or even years.
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ranking = 2
keywords = thromboembolism
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