Cases reported "Tooth Demineralization"

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1/3. Effect of recombinant human platelet-derived growth factor-BB and bone morphogenetic protein-2 application to demineralized dentin on early periodontal ligament cell response.

    The purpose of this study is to investigate the early responses of human periodontal ligament cells attached to recombinant human platelet-derived growth factor-BB and bone morphogenetic protein-2 applied EDTA-demineralized dentin. One hundred and seventy-four root-planed flat dentin blocks were prepared from the mid-third of periodontally diseased human tooth roots. After demineralization with 24% EDTA (pH 7.02) 120 dentin blocks were treated with 0.5 and 1 microgram/ml rhPDGF-BB, 1 and 3 micrograms/ml rhBMP-2 and only MEM as control (24/group). Human periodontal ligament cells (HPLC) were seeded on these dentin surfaces and incubated. The alkaline phosphatase (ALP) activity and protein concentration of the attached cell were assessed at d 2, 4 and 7. Fifty-four dentin blocks were seeded with HPLC after application of 1 microgram/ml rhPDGF-BB, 3 micrograms/ml rhBMP-2 and MEM (18/group) and then incubated. At d 2, 4 and 7, the attached cells were stained and counted under light microscope. The results showed a significant increase of protein concentration and cell number in PDGF-BB treated groups than control (p < 0.05, p < 0.01) but not the ALP activity, and a significant increase of ALP activity was observed in BMP-2 treated groups than control (p < 0.05) but protein concentration and cell number remained almost the same over time. Thus, rhPDGF-BB and rhBMP-2 application to EDTA demineralized dentin surfaces promote the early human periodontal ligament cell responses by increasing cell proliferation and differentiation, respectively, which would ultimately enhance periodontal regeneration.
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2/3. Extended fissure sealants: an adjunctive aid in the prevention of demineralization around orthodontic bands.

    Banding of molars is still the attachment mode of choice to the majority of clinical orthodontists. One of the acknowledged hazards of orthodontic treatment continues to be the presence of clinically detectable areas of enamel demineralization following the removal of orthodontic appliances. Factors that contribute to this demineralization include inaccurate adaptation of the bands and breakdown of the seal as a consequence of the inadequate bonding strength of the cements and their solubility in oral fluids. Traditional cleaning methods limit adequate plaque control to those areas gingival and incisal to the cemented bands. The iatrogenically created defective band-tooth interface areas pose particular problems, because the ingress of food particles and bacterial plaque make these areas prone to demineralization. A technique is introduced whereby fissure sealant is extended to cover the entire occlusal perimeter, effectively sealing the band-tooth circumferential interface. This technique represents an additional method of prophylaxis against the demineralization that can accompany orthodontic intervention.
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3/3. acro-osteolysis (Hajdu-Cheney) syndrome: report of a case with abnormal tooth structure.

    The acro-osteolysis (Hajdu-Cheney) syndrome is a rare disorder of bone metabolism characterized by progressive dissolution of a number of bones. Although previous reports have detailed several dental abnormalities associated with this syndrome, this is the first report describing structural changes in the dentin and cementum of teeth.
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