1/2. Intravenous therapy of metronidazole-resistant trichomonas vaginalis.metronidazole resistance is an uncommon cause of treatment failure of trichomonas vaginalis. High-dose intravenous metronidazole was used successfully to treat a patient in whom repeated oral therapy with this agent had failed. metronidazole resistance was documented by aerobic cultures for susceptibility; anaerobic cultures failed to indicate resistance. metronidazole serum levels were documented. With failure of repeated oral therapy, intravenous metronidazole may be indicated if there is no evidence of other causes for treatment failure, such as patient noncompliance or reinfection.- - - - - - - - - - ranking = 1keywords = treatment failure (Clic here for more details about this article) |
2/2. metronidazole resistance of trichomonas vaginalis as a cause of treatment failure in trichomoniasis--A case report.Six isolates of a strain (MRP-MT) of trichomonas vaginalis obtained from a woman before and after unsuccessful treatment with metronidazole had an appreciably lower susceptibility to metronidazole both in vitro in the aerobic tube assay and in vivo in the mouse assay than did control strains from patients cured with standard doses of the drug. Our results support recent evidence that metronidazole-resistant strains of T vaginalis do cause treatment failure. Resistance of these strains could be detected in vitro under only aerobic but not anaerobic conditions. The prevalence of metronidazole-resistant strains of T vaginalis should be kept under surveillance in order to estimate their clinical importance. The patient harbouring the resistant strain MRP-MT was finally cured with increased doses of ornidazole.- - - - - - - - - - ranking = 2.5keywords = treatment failure (Clic here for more details about this article) |