Cases reported "Tuberculosis, Lymph Node"

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1/2. histamine poisoning in tuberculous patients after ingestion of tuna fish.

    Two cases of histamine poisoning after ingestion of tuna fish occurred in tuberculous patients. The symptoms and circumstances leading to the reaction were identical to those previously reported for 2 other varieties of fish, skipjack and Sardinella (Amblygaster) sirm. isoniazid, which is an invariable constituent of any antituberculous drug regimen, is a potent histamine inhibitor. When tuna fish, which has a high histamine content, is eaten, the histamine concentration in the tissues tends to increase, producing features of histamine intoxication.
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2/2. histamine poisoning after ingestion of spoiled raw tuna in a patient taking isoniazid.

    An 83-year-old woman taking isoniazid (INH) suddenly developed a headache, palpitations, and skin eruptions with itching while eating raw tuna. The symptoms were compatible with those of histamine intoxication. When given fresh raw tuna to eat, no such reactions were evoked in this patient. The episode was speculated to be due to two conditions; eating spoiled raw tuna and at the same time being on a course of INH, a potent histaminase inhibitor. We should therefore be aware of the possible adverse effects due to the interactions between drugs and foods.
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