1/19. Synchronous genital tract neoplasms.Synchronous genital tract neoplasms constitute a more common clinical problem than would be generally expected. This case focuses on mixed mullerian tumours and postulates a mechanism for an increased incidence found associated with synchronous genital tract neoplasms.- - - - - - - - - - ranking = 1keywords = mullerian (Clic here for more details about this article) |
2/19. Mullerian adenosarcoma of the uterine cervix.Sarcomas in the uterine cervix are rare, the incidence being 0.5% to 1% of all cervical malignancies. This is a report of cervical mullerian adenosarcoma, which was encountered in a hysterectomy performed for prolapse. The tumor was composed of benign glandular elements and malignant stromal component, thus justifying its nomenclature. We wish to emphasize the distinctive morphological features of this rare cervical tumor.- - - - - - - - - - ranking = 1keywords = mullerian (Clic here for more details about this article) |
3/19. chylous ascites following treatment for gynecologic malignancies.BACKGROUND: chylous ascites is a rare complication following abdominal radiation or para-aortic lymph node dissection in the management of gynecologic malignancies. Treatment options include dietary restriction with addition of medium-chain triglycerides, serial paracenteses, total parenteral nutrition, and somatostatin. Current opinion advocates that surgical exploration and peritoneo-venous shunts be reserved for refractory cases. CASES: Two patients developed chylous ascites, one after completion of surgical staging and chemoradiation for stage IIB squamous carcinoma of the cervix and one following para-aortic lymph node dissection for recurrent malignant mixed mullerian tumor of the endometrium. In both cases resolution of the chylous ascites followed placement of a peritoneo-venous shunt. CONCLUSIONS: chylous ascites should be considered in the differential diagnosis of ascites in patients with gynecologic malignancy treated with radiation or para-aortic lymph node dissection.- - - - - - - - - - ranking = 1keywords = mullerian (Clic here for more details about this article) |
4/19. Mullerian adenosarcoma with sarcomatous overgrowth of the cervix presenting as cervical polyp: a case report and review of the literature.An aggressive variant of adenosarcoma, mullerian adenosarcoma with sarcomatous overgrowth (MASO) in the cervix is extremely rare. This variant contains obvious, high-grade sarcoma in addition to a low-grade form. In this report, we describe a case of MASO of the uterine cervix and review the clinical and pathological features of these tumors. The patient was a 37-year-old woman with a cervical polypoid mass, which was morphologically considered as a benign endocervical polyp. Microscopically, polypoid cervical mass showed diffuse and dense malignant spindle cell proliferation around the benign endocervical glands and also an area of markedly anaplastic and pleomorphic spindle cell proliferation, so called, sarcomatous overgrowth. Total abdominal hysterectomy and bilateral salpingo-oophorectomy with pelvic lymph node dissection were performed. The patient has been followed-up and neither chemotherapy nor other adjuvant therapies have been administered. At present, she has been clinically free of disease for 9 months since she received surgery. It is extremely rare that MASO of the uterine cervix is presented in premenopausal woman. Gynecologists and pathologists should be aware of the difficulties associated with a delay in the diagnosis of MASO when the tumor is present as a benign looking cervical polyp.- - - - - - - - - - ranking = 1keywords = mullerian (Clic here for more details about this article) |
5/19. Mullerian papilloma of the cervix in a child with multiple renal cysts.An 18-month-old girl was referred for evaluation of vaginal bleeding and a renal mass. ultrasonography and computed tomography revealed multiple simple cysts within the left kidney and a normal right kidney. At vaginoscopy, a 1-cm frond-like papillary lesion overlying the cervix was identified. The pathologic diagnosis was mullerian papilloma, a rare benign tumor of the vagina and uterine cervix. None of the approximately 40 previously reported cases have been associated with renal anomalies, despite the historical classification of these lesions as mesonephric papillomas. We report the first patient with both a renal anomaly and mullerian papilloma of the uterine cervix.- - - - - - - - - - ranking = 2keywords = mullerian (Clic here for more details about this article) |
6/19. Cytologic features of ciliated adenocarcinoma of the cervix: a case report.BACKGROUND: Ciliation is a normal finding in the endometrium, fallopian tubes and cervix. Because cilia are characteristically lost when malignant tumors arise at these sites, the detection of cilia on light microscopy is frequently used to support a benign diagnosis. Ciliated carcinomas of mullerian duct origin, however, do occur, albeit rarely, and can pose a potential diagnostic difficulty in cytologic specimens. CASE: A woman with a histologically confirmed ciliated adenocarcinoma of the cervix had prior liquid-based cervical cytology showing atypical, ciliated glandular cells that initially raised the diagnostic consideration of tubal metaplasia. A concurrent biopsy, however, revealed focally ciliated adenocarcinoma of the cervix. CONCLUSION: awareness of the ciliated variant of adenocarcinoma of the cervix is important to avoid overreliance on ciliation as a definitive feature of benignity in cervical cytologic specimens.- - - - - - - - - - ranking = 1keywords = mullerian (Clic here for more details about this article) |
7/19. carcinoma in situ of the Fallopian tube associated with cervical carcinoma. Case report.A case of carcinoma in situ of the fallopian tube in a 55-year-old woman, associated to cervical carcinoma is described. The necessary criteria for the diagnosis of pre-invasive carcinoma of the fallopian tube, among which the number of mitoses seems to be of great importance, are discussed. This previously unreported association of carcinoma in situ of the fallopian tube, with carcinoma of the uterine cervix, emphasizes the notion of the multicentric neoplastic possibilities of the mullerian tract derivatives.- - - - - - - - - - ranking = 1keywords = mullerian (Clic here for more details about this article) |
8/19. Unilateral cervical cancer in a patient with cervix duplex.BACKGROUND: Although uterine anomalies are uncommon, gynecologists must be aware of the anatomical challenges that may be encountered from these anomalies. Cervical cancer in the context of a mullerian lateral fusion defect is rare. CASE: A case of a unilateral IB1 squamous cell carcinoma of the cervix in the setting of a complete uterovaginal septum and cervix duplex is described. CONCLUSION: Uterine anomalies compound diagnostic difficulty of routine pathology. Thorough examination and evaluation are crucial for timely diagnosis and treatment. Genital tract duplication, although rare, should always be considered.- - - - - - - - - - ranking = 1keywords = mullerian (Clic here for more details about this article) |
9/19. Mullerian adenosarcoma of the uterine cervix with heterologous elements: a light and electron microscopic study.A mullerian adenosarcoma with heterologous elements having the gross appearance of a sarcoma botryoides occurred in the uterine cervix of a 14-year-old girl. Histologically, the tumor was composed of an admixture of benign-appearing glands and a sarcomatous stroma, the latter containing areas of undifferentiated sarcoma and endometrial stromal sarcoma, as well as heterologous elements consisting of rhabdomyosarcoma and hyaline cartilage. No malignant epithelial component was observed. The distribution of benign mullerian-type glands throughout the tumor simulated a malignant mixed mullerian tumor in appearance. Ultrastructural studies of the stromal elements of the neoplasm suggest origin from primitive mullerian stroma, and the glands have features of primitive mullerian epithelium. This study supports the concept that the malignant mixed mullerian tumor and related mullerian sarcomas originate from a common undifferentiated multipotential mullerian stem cell.- - - - - - - - - - ranking = 8keywords = mullerian (Clic here for more details about this article) |
10/19. Cervical adenocarcinoma arising in florid mesonephric hyperplasia: report of a case with immunocytochemical studies.A case of mesonephric adenocarcinoma of the uterine cervix arising in florid mesonephric hyperplasia is reported. The reviewed literature contained many cases of cervical "mesonephroma" but only a few of these were considered to be demonstrably of mesonephric origin. These tumors were usually associated with proliferating mesonephric remnants in the cervix. Similar tubuloglandular mesonephric proliferations without formation of a frankly malignant tumor have also been described in the cervix, most recently as florid mesonephric hyperplasia. This latter entity appears to be benign. carcinoembryonic antigen (CEA) was focally positive in this cervical adenocarcinoma, suggesting that CEA may not be useful in distinguishing this variant from the more common mullerian adenocarcinoma of the cervix.- - - - - - - - - - ranking = 1keywords = mullerian (Clic here for more details about this article) |
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