Cases reported "Uterine Neoplasms"

Filter by keywords:



Filtering documents. Please wait...

1/53. Pleomorphic rhabdomyosarcoma of the uterus in a postmenopausal woman with elevated serum CA125.

    BACKGROUND: Pure rhabdomyosarcoma of the uterus is an exceedingly rare tumor. While there are no commonly associated tumor markers, a previously reported case confirmed CA125 production by a pure uterine rhabdomyosarcoma. CASE: We describe a postmenopausal woman who presented with vaginal bleeding and was diagnosed with pleomorphic rhabdomyosarcoma of the uterus. Of particular interest was an elevated serum CA125 level at presentation. Immunohistochemical staining with CA125 antibody, however, showed no activity within the tumor. Despite aggressive therapy, the patient experienced distant nodal metastases and succumbed to the disease within 25 months of diagnosis. CONCLUSION: Our patient illustrates the typical presentation and aggressive behavior of this rare neoplasm. While serum CA125 may be a useful tumor marker in selected patients, elevated levels do not directly reflect tumor burden when associated with negative immunohistochemical staining.
- - - - - - - - - -
ranking = 1
keywords = rhabdomyosarcoma
(Clic here for more details about this article)

2/53. Embryonal rhabdomyosarcoma of the uterine corpus in a 76-year-old patient.

    BACKGROUND: Primary embryonal rhabdomyosarcoma of the uterine corpus is an extremely rare tumor. A case of rhabdomyosarcoma originating in the uterine myoma is presented with a review of the literature. CASE: A 76-year-old female presented with a half-year history of abdominal swelling and fever of unknown origin. A 15 x 15 x 17 cm myoma-like tumor was noted on the anterior wall of the uterine myometrium. The patient underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy. The histology and immunohistochemistry aided in the final diagnosis of a pure embryonal rhabdomyosarcoma of the uterine corpus. This patient received three courses of CYVADIC chemotherapy consisting of cyclophosphamide, vincristine, doxorubicin, and dacarbazine after the surgery and is now alive with no evidence of disease 10 months from her surgery. CONCLUSION: This case is extremely rare with respect to the uterine corpus origin, especially the myoma nodule and the age of the patient.
- - - - - - - - - -
ranking = 1
keywords = rhabdomyosarcoma
(Clic here for more details about this article)

3/53. Uterine pleomorphic rhabdomyosarcoma in a patient receiving tamoxifen therapy.

    INTRODUCTION: tamoxifen has been used as adjuvant therapy for the treatment of breast cancer. Its use has been associated with the development of proliferative endometrial lesions such as polyps, hyperplasia, and carcinoma. Mesenchymal tumors including malignant mixed mullerian tumors, endometrial stromal sarcomas, adenosarcomas, and leiomyosarcomas have been more recently described with tamoxifen use. CASE REPORT: This report describes the first case of a pure uterine rhabdomyosarcoma in a patient receiving tamoxifen therapy. DISCUSSION: Although uterine rhabdomyosarcomas are rare tumors and may arise de novo, we discuss the possible role of tamoxifen in the development of these mesenchymal tumors.
- - - - - - - - - -
ranking = 0.85714285714286
keywords = rhabdomyosarcoma
(Clic here for more details about this article)

4/53. A malignant triton tumor with an unbalanced translocation (1;13)(q10;q10) and an isochromosome (8)(q10) as the sole karyotypic abnormalities.

    The karyotype of a malignant nerve sheath tumor with rhabdomyosarcomatous differentiation (malignant triton tumor) of a 58-year-old woman is reported. The tumor revealed an isochromosome for the long arm of chromosome 8 and an unbalanced translocation (1;13)(q10;q10) leading to a gain of the long arm of chromosome 1 as the sole karyotypic abnormalities.
- - - - - - - - - -
ranking = 0.14285714285714
keywords = rhabdomyosarcoma
(Clic here for more details about this article)

5/53. rhabdomyosarcoma of the corpus of the uterus: a case report.

    A case of uterine rhabdomyosarcoma is presented. Preoperative chemotherapy resulted in an excellent response.
- - - - - - - - - -
ranking = 0.14285714285714
keywords = rhabdomyosarcoma
(Clic here for more details about this article)

6/53. Uterine adenosarcoma with rhabdomyosarcomatous overgrowth. Brief communication.

    A case of a rhabdomyosarcomatous uterine adenosarcoma with sarcomatous overgrowth is presented. The rhabdomyosarcoma component constituted about 90% of the tumor. The patient died 5 years and 5 months after the operation. Rhabdomyosarcomatous uterine adenosarcoma even with a sarcomatous overgrowth does not seem to be more malignant than other adenosarcomas.
- - - - - - - - - -
ranking = 0.85714285714286
keywords = rhabdomyosarcoma
(Clic here for more details about this article)

7/53. rhabdomyosarcoma of the uterus: report of two cases, including one of the spindle cell variant.

    Most uterine sarcomas fall into the category of leiomyosarcoma, endometrial stromal sarcoma, or undifferentiated sarcoma. Pure rhabdomyosarcomas are extremely rare, although a rhabdomyosarcomatous element may be present as a component of an adenosarcoma or carcinosarcoma (malignant mixed mullerian tumor). This report describes two uterine rhabdomyosarcomas in 28- and 67-year-old women. These were of spindle cell and pleomorphic types, respectively. At presentation the pleomorphic rhabdomyosaroma was stage IV, exhibiting massive pelvic and abdominal dissemination that mimicked an ovarian neoplasm. The spindle cell rhabdomyosarcoma was stage I, being confined to the uterus. Grossly, both uterine tumors had a polypoid appearance. Immunohistochemically, tumor cells were positive with the skeletal muscle markers sarcomeric actin, myoglobin, and myoD1. The patient with stage IV disease died within a short time of diagnosis and the other patient is alive and well at 2 years' follow-up. This report adds to the published literature on uterine rhabdomyosarcomas. This is the first reported uterine case of the spindle cell variant of embryonal rhabdomyosarcoma. Based on these cases and the published literature, rhabdomyosarcoma, especially the pleomorphic variant, appears to be a very aggressive neoplasm with an extremely poor prognosis. Immunohistochemical demonstration of skeletal muscle differentiation is necessary for a definitive diagnosis.
- - - - - - - - - -
ranking = 1
keywords = rhabdomyosarcoma
(Clic here for more details about this article)

8/53. Rhabdoid epithelioid leiomyosarcoma of the uterine corpus: a case report and literature review.

    A case of epithelioid leiomyosarcoma of the uterus with rhabdoid phenotype and early rhabdomyoblastic differentiation is described. A 72-year-old woman with a 5-week history of increased abdominal girth was found to have a large pelvic mass. The uterus revealed a large intramyometrial and left adnexal necrotic tumor that had spread to the small bowel mesentery and to the anterior abdominal peritoneum. The tumor was an epithelioid leiomyosarcoma with rhabdoid phenotype and focal early rhabdomyoblastic differentiation, as confirmed by immunohistochemical and ultrastructural techniques. Also called composite extrarenal rhabdoid tumor (CERT), this lesion should be differentiated from malignant mixed mullerian tumor, rhabdomyosarcoma, endometrial stromal sarcoma, and pure rhabdoid tumors of the uterus. The recognition of a rhabdoid phenotype is of clinical importance since these tumors are prone to be aggressive.
- - - - - - - - - -
ranking = 0.14285714285714
keywords = rhabdomyosarcoma
(Clic here for more details about this article)

9/53. Combined therapy to prevent complete pelvic exenteration for rhabdomyosarcoma of the vagina or uterus.

    Three children with rhabdomyosarcoma (sarcoma botryoides) of the vagina or uterus were managed by modified radical resection combined with pre- and/or postoperative chemotherapy and high-dose irradiation. This plan of therapy contrasts sharply with the conventional approach: i.e., pelvic exenteration consisting of cystectomy, hystovaginectomy, and oophorectomy, with urinary diversion by ureteroileostomy or ureterosigmoidostomy. Two patients had complete regressions of tumor following preoperative chemotherapy and irradiation. The third patient received no preoperative therapy, but was given postoperative radium implantation, irradiation, and chemotherapy. The surgical approach consisted of hystovaginectomy and oophorectomy without urinary diversion. These patients are free of tumor for 32, 44, and 54 months, respectively. There were no serious toxic reactions to the drugs, nor any significant postoperative urinary tract problems. The results reported here suggest that hystovaginectomy and oophorectomy coordinated with chemotherapy and irradiation is an acceptable alternative to pelvic exenteration in patients with sarcoma botryoides of the vagina or uterus.
- - - - - - - - - -
ranking = 0.71428571428571
keywords = rhabdomyosarcoma
(Clic here for more details about this article)

10/53. Uterine carcinosarcoma with complete sarcomatous overgrowth mimicking pure embryonal rhabdomyosarcoma.

    A polypoid endometrial tumor arising in an 89-year-old woman was composed of pure embryonal rhabdomyosarcoma, whereas the metastatic tumor in the pelvic lymph nodes was entirely adenocarcinomatous. This finding indicates that some rhabdomyosarcomas of the uterus represent carcinosarcomas with extensive or total overgrowth by the sarcomatous component.
- - - - - - - - - -
ranking = 0.85714285714286
keywords = rhabdomyosarcoma
(Clic here for more details about this article)
| Next ->


Leave a message about 'Uterine Neoplasms'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.