1/13. Localized vitiligo and frontoethmoidal meningoencephalocele.A child with frontoethmoidal meningoencephalocele in whom localized facial vitiligo developed after surgical correction of the encephalocele is presented. The potential role of the ocular disease accompanying the encephalocele in the development of the hypopigmentation is discussed.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
2/13. Differential expression of inhibitory or activating CD94/NKG2 subtypes on MART-1-reactive T cells in vitiligo versus melanoma: a case report.Selection and activation of T cells is tightly regulated by both antigen-specific receptors and co-receptors to ensure that responses to self antigens are largely avoided. By T cell receptor clonotypic mapping and staining with tetrameric HLA-peptide complexes, we demonstrate the presence of melanocyte differentiation antigen MART-1 specific T cells in the areas of destruction of both neoplastic and normal melanocytic cells in a case of a primary melanoma and its associated hypopigmentation. These self reactive T cells expressed CD94/NKG2 major histocompatibility complex class I specific C-type lectin-like receptors. This family of receptors includes both activating and inhibitory isoforms. Thus, we performed a detailed analysis that revealed the exclusive presence of inhibitory NKG2-A/B receptors in the vitiligo-like leukoderma, whereas both the inhibitory receptors and the activating NKG2-C/E isoforms were present within the tumor. Our data suggest the differential expression of killer inhibitory receptors as a possible mechanism to regulate T cell responses to self antigens.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
3/13. vitiligo-like lesions and diffuse lightening of the skin in a pediatric patient treated with imatinib mesylate: a noninvasive colorimetric assessment.Imatinib mesylate is a drug that has been recently approved for the treatment for chronic myeloid leukemia. It acts as a potent and selective inhibitor of BCR-ABL tyrosine kinase. It also inhibits both c-kit and platelet-derived growth factor receptor tyrosine kinases. hypopigmentation of the skin in patients receiving this drug has been recently reported. We report a 17-year-old Caucasian patient affected by chronic myeloid leukemia in therapy with imatinib mesylate who developed hypopigmented vitiligo-like patches and generalized lightening of the skin. In order to evaluate the lightening observed clinically, we measured the progressive skin color hypopigmentation by using a colorimeter over several months. The colorimetric evaluation confirmed the generalized and gradual lightening of patient's skin over treatment with imatinib mesylate. We believe that this is the first reported instance of vitiligo-like lesions in a pediatric patient treated with imatinib mesylate, and the second in a Caucasian patient.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
4/13. vitiligo: care and treatment.vitiligo is a condition of hypopigmentation. An overview of the diseases and treatment options are discussed. A case study is presented in which encouraging results have been obtained using PUVA and fluocinonide. nursing considerations are listed.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
5/13. Two cases of nickel dermatitis showing vitiligo-like depigmentations.The authors reviewed two patients showing "vitiligo-like depigmentations" where the skin had been in close contact with a metal spectacle frame made of nickel alloy. In spite of the hypersensitivity to nickel in both patients, they showed clinical and histologic findings indicate that the formation of "vitiligo-like depigmentation" does not result from posinflammatory hypopigmentation but from chemical hypomelanosis. We could not explain the underlying mechanisms; however, the speculation that the "vitiligo-like depigmentation" may come from the direct effect of the nickel itself, prompted us to report these cases.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
6/13. Eosinophilic fasciitis (Shulman syndrome) in association with morphea, immunological disturbance and profuse achromia.A case of localized eosinophilic fasciitis (EF) is reported. Profuse hypopigmentation, guttate morphea and immunological disturbances accompanied the subcutaneous changes. The case links Shulman's syndrome with classical localized cutaneous scleroderma.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
7/13. Ocular abnormalities associated with cutaneous melanoma and vitiligolike leukoderma.Several varieties of ocular pathology are associated with acquired cutaneous hypomelanosis (leukoderma; vitiligo). Our current study was undertaken to investigate the relationship between ophthalmologic disorders and a specific depigmentary phenomenon, the vitiligolike leukoderma of cutaneous melanoma. Over the past 14 years, eight patients with cutaneous melanoma and widespread areas of hypopigmentation were identified at the Pigmented Lesion Clinic of the massachusetts General Hospital. The seven patients who underwent ophthalmologic examination had pigment-related ocular abnormalities. Among these were inflammations of the uveal tract in three patients, heterochromia in two, halo nevi of the choroid in one, and hypopigmentation and/or atrophy of the retinal pigment epithelium or choroid in four. Our findings demonstrate that ocular disease may be a component in a syndrome consisting also of cutaneous melanoma and vitiligolike leukoderma and suggest the need for complete ophthalmologic examinations in patients with melanoma and leukoderma.- - - - - - - - - - ranking = 2keywords = hypopigmentation (Clic here for more details about this article) |
8/13. vitiligo on tuberculoid patches--a case report.A case of tuberculoid leprosy with complete depigmentation on its active margins, in a predisposed individual to vitiligo is presented. The postulated mechanism of hypopigmentation vis-a-vis leprosy lesions is discussed in brief in the context of the presenting unusual association.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
9/13. The occurrence of vitiligo after psoralens and ultraviolet a therapy.The ability of photochemotherapy with 8-methoxypsoralen in conjunction with high-intensity long-wave ultraviolet light (PUVA) to stimulate melanogenesis is well known. This effect on the pigmentary system is evidenced by the diffuse tanning of clinically normal skin in PUVA-treated patients with psoriasis and other disorders, as well as by the repigmentation of lesions in vitiligo. It is now recognized that there may be additional pigmentary effects, resulting in clinical lesions such as PUVA mottling, PUVA lentigines, and localized hypopigmentation. We have documented the occurrence of yet another association with puva therapy--the paradoxical appearance of widespread hypopigmentation consistent with vitiligo in three PUVA-treated patients, one with psoriasis and two with mycosis fungoides. Histologic and ultrastructural findings are presented.- - - - - - - - - - ranking = 2keywords = hypopigmentation (Clic here for more details about this article) |
10/13. Raccoon-like periorbital leukoderma from contact with swim goggles.A 12-year-old girl developed a periorbital leukoderma from contact with swim goggles. She had worn the same goggles the preceding year and re-used them after the leukoderma had cleared without any ill effects. The hypopigmentation was believed to be caused by the leakage of breakdown products in the neoprene rubber or glue. These breakdown products may have caused a toxic rather than an allergic reaction on skin contact, inhibiting melanin production possibly by competitive inhibition of tyrosine oxidation. These chemical compounds probably leaked from the goggles and were eventually exhausted. This possibility may explain why the leukoderma did not recur after re-use of the goggles.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
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