11/13. Perioral leukoderma simulating vitiligo from use of a toothpaste containing cinnamic aldehyde.Perioral leukoderma simulating vitiligo developed in a 25-year-old woman. A patch test to cinnamic aldehyde was positive; depigmentation was observed at the patch test site three months after initial application. No changes in pigmentation occurred from a concomitant allergic patch test reaction to neomycin sulfate; only hyperpigmentation occurred at the site of an irritant patch test reaction to nonanoic acid. A toothpaste containing cinnamic aldehyde was implicated; perioral hypopigmentation resolved when a toothpaste without cinnamic aldehyde was substituted. A repeated patch test to cinnamic aldehyde again showed depigmentation at the patch test site three months after application.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
12/13. Analysis of the lymphocytic infiltrate in a case of vitiligo.We report a case of vitiligo notable for a degree and pattern of lymphocytic inflammation. hypopigmentation and subsequent depigmentation developed in a 65-year-old man. Initial skin biopsy specimen from the border of a patch of hypopigmentation revealed a moderately dense perivascular and interstitial infiltrate of lymphocytes with exocytosis into epidermis and follicular epithelium. The pattern of the infiltrate suggested the diagnosis of cutaneous T-cell lymphoma or connective-tissue disease. Immunophenotypic analysis revealed a mature T-cell population with retention of pan-T-cell markers. Analysis of the T-cell receptor genome did not identify a rearranged clone. Six months later, the clinical and histologic findings were typical in a noninflamed lesion of vitiligo.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
13/13. ectopia lentis et pupillae with patchy depigmentation of the skin, hair and lashes: a new association.We describe a case of a four year-old boy, with congenital ectopia lentis et pupillae, who developed patchy unilateral depigmentation of the skin, hair and lashes. The association between ectopia lentis et pupillae and transillumination of the iris is well documented in the literature, but it has never been reported with skin hypopigmentation.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
| <- Previous | |