Cases reported "Yersinia Infections"

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1/18. HLA-DP restricted chlamydia trachomatis specific synovial fluid T cell clones in Chlamydia induced Reiter's disease.

    synovial fluid (SF) mononuclear cells from a patient with chlamydia trachomatis induced acute Reiter's disease were directly by limiting dilution in a representative protocol using phytohemagglutinin in the cloning medium. Out of 76 alpha beta-TCR CD4 T lymphocyte clones, 7 were shown to specifically recognize C. trachomatis in a proliferation assay. The antigen recognition of these clones was HLA-DP restricted. Unexpectedly, 2 HLA-DR restricted clones showed a proliferative response to yersinia enterocolitica O3, though the patient had no history of yersinia infection. The high frequency of SF derived T cells with specificity for species-specific chlamydial antigens and the limited diversity of HLA class II restriction of these clones may indicate an oligoclonal synovial T cell response to persistent intraarticular chlamydia.
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2/18. Yersinia infection mimicking recurrence of gastrointestinal stromal tumor.

    gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. So far, surgical resection has been the only curative treatment, but new options became available with the application of imatinib (Glivec) as a specific molecular inhibitor. Even after complete resection, GISTs have a high rate of recurrence and disease-linked mortality. Here we report on the case of a clinically well 57-year-old woman who presented to us 3 years after resection of a GIST of the small intestine. Abdominal ultrasound and CT scan showed intestinal wall thickening in the area of anastomosis and mesenteric lymphadenopathy, suggesting a recurrence of the primary GIST. However, serological testing was positive for yersinia antibodies. Surgical exploration revealed an asymptomatic infection with yersinia enterocolitica serotype O9, proven by positive culture and histology, which showed no evidence of malignancy. Prognostic variables for GIST as well as diagnostic measures and limitations for yersiniosis are discussed. In the end, only surgical exploration and histological analysis could establish the final diagnosis. In conclusion, GISTs have a high likelihood of recurrence even after complete resection, but an asymptomatic infection such as yersiniosis must be considered as a differential diagnosis to GIST recurrence.
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keywords = yersinia
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3/18. yersinia infections in patients with homozygous beta-thalassemia associated with iron overload and its treatment.

    patients with homozygous beta-thalassemia are at increased risk of serious infections. yersinia enterocolitica is an organism with a predilection for these and other iron-overloaded patients. Three young adult patients with beta-thalassemia who were chronically transfused and developed yersiniosis are reported. iron overload and desferrioxamine use are predisposing factors, as supported by clinical, animal, and in vitro data. Iron excess both immunologically compromises the host and greatly enhances yersinial growth. Desferrioxamine may make host iron even more bioavailable to Yersinia. Recognition of this association and unusual manifestations in these patients such as an appendicitis-like syndrome may direct clinicians to earlier antiyersinial therapy and temporary cessation of chelation.
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ranking = 0.44521203396346
keywords = yersinia
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4/18. yersinia enterocolitica infection in a patient with hemachromatosis masquerading as proximal colon cancer with liver metastases: report of a case.

    A patient with genetic hemachromatosis presented with a clinical picture suggesting malignancy and CT evidence of lesions in the right colon and liver. colonoscopy failed to confirm the suspected diagnosis. blood and stool cultures were positive for yersinia enterocolittica infection. This case illustrates the need to confirm clinically and radiologically suspected malignancy. It also serves as a model of how localized gastrointestinal pathology can result from the interaction of host genetic factors and specific microbial species.
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keywords = yersinia
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5/18. Thrombotic thrombocytopenic purpura mimicking acute small bowel Crohn's disease.

    A 39 year old woman presented with a short history of bloody diarrhoea. She subsequently developed microangiopathic haemolysis, platelet consumption, and renal impairment. Initial investigations suggested underlying Crohn's disease of the terminal ileum complicated by sepsis and disseminated intravascular coagulation. However, after resection of a perforated caecum and terminal ileum, the diagnosis of thrombotic thrombocytopenic purpura was made. There was weak serological evidence of yersinia infection, this may have caused the early localisation of the lesions to the terminal ileum. This is believed to be the first report of thrombotic thrombocytopenic purpura affecting the small bowel alone at presentation.
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6/18. Late complications after a yersinia enterocolitica epidemic: a follow up study.

    Ninety four Finnish conscripts were affected by a yersinia enterocolitica epidemic in 1973. Thirteen years later 75 men completed a questionnaire about their present health. One half had no health problems, and the most common complaints in the other subjects were musculoskeletal disorders. Sixteen men wanted to be re-examined. In three cases a chronic connective tissue disease was diagnosed. Two men had ankylosing spondylitis. The most notable results of this study were (a) the fairly low number of late complications, (b) the close correlation between complications and the hla-b27 antigen, and (c) the correlation between raised yersinia antibody titres and the late complications. The nature of the primary causative agent may affect the development of late complications.
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keywords = yersinia
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7/18. Post-yersinial arthritis in Cleveland, england.

    Four cases of post-yersinial reactive arthritis are described. All patients presented with an acute lower limb arthropathy with features of an associated enthesopathy. Two patients had restriction of axial skeletal movements. Systemic features were prominent in three, including weight loss and malaise. Mean age of onset was 34 years. Three patients gave a history of antecedent diarrhoea within the previous month. Three patients had raised titres to Y enterocolitica type 0:3 (ranging from 1 in 320 to 1 in 2560) and one had raised titres to Y pseudotuberculosis type 2 at 1 in 640. Two of the three patients with Y enterocolitica reactive arthritis ran a chronic course with low grade arthropathy of lower limbs and back stiffness. One patient developed radiological sacroiliitis at two years, and two patients had an increased sacroiliac index, though x rays of the sacroiliac joints were normal. The patient with Y pseudotuberculosis reactive arthritis had a self limiting disease with spontaneous resolution over six months.
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ranking = 1.1130300849086
keywords = yersinia
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8/18. association of pancreas affection and yersiniosis. A case report.

    A case history of a 25-year-old female is reported. She had no diseases predisposing for pancreatic disease. A few days after a familial outbreak of yersinia enteritis, she again became ill and was referred to hospital. Clinical and laboratory examination made it likely that she underwent an acute pancreatic affection, and the serological test proved that she had been through an acute yersiniosis. The coincidental occurrence may of course be by change, but considering the immunological aspects of secondary yersiniosis, there might also be an etiological link.
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ranking = 0.22260601698173
keywords = yersinia
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9/18. Localized polyartheritis nodosa in the lower limb with new bone formation.

    A 61-year-old male patient, with a burned-out ankylosing spondylitis, developed polyarteritis in the right lower limb, associated with periosteal new bone formation in tibia and fibula. An acute exacerbation may have been precipitated by an infection with yersinia. HLA type: A 28, 26, B5, 27, Cwl.
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ranking = 0.22260601698173
keywords = yersinia
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10/18. Immunohistology and aetiology of histiocytic necrotizing lymphadenitis. Report of three instructive cases.

    Three cases of histiocytic necrotizing lymphadenitis are reported. Two patients came from vietnam and the third from greece. In all cases there was infection with yersinia enterocolitica of serogroup 9 or 3. Cervical lymph nodes were examined. Histologically, the characteristic necrosis developed in large foci of so-called T-associated plasma cells. Immunological analysis showed that these cells have characteristic markers of helper/inducer T cells, but do not express sheep erythrocyte receptors. The T-associated plasma cells perished by pyknosis and were then phagocytosed and digested by macrophages, which were present in large numbers. The necrotic areas were exclusively located in hyperplastic T regions. The B-cell system did not play a role in the reaction. T-associated plasma cells have been renamed 'plasmacytoid T cells' because they contain abundant rough endoplasmic reticulum ('plasmacytoid') and show immunological features of T cells. It appears likely that plasmacytoid T cells are the counterparts of plasma cells of the B-cell system that secrete lymphokines instead of immunoglobulin.
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keywords = yersinia
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