Cases reported "Chlamydophila Infections"

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1/19. A case of splenic abscess due to Chlamydia pneumoniae.

    In this report, a case of chlamydial disease with splenic abscess associated with Chlamydia pneumoniae antigen and antibody was described. On spleen biopsy of the patient, an antigen specific to C.pneumoniae was detected by immunofluorescence staining with a monoclonal antibody. Serologic studies revealed a high antibody titer to C.pneumoniae in sera collected from the patient and her husband. Treatment with the antibiotic minocycline improved her condition. ( info)

2/19. Bilateral pleural effusion and a subsegmental infiltrate due to Chlamydia pneumoniae in a mechanically ventilated patient.

    A case of Chlamydia pneumoniae infection with bilateral pleural effusion and a subsegmental pulmonary infiltrate in an intubated and mechanically ventilated critically ill patient is described. diagnosis was made by polymerase chain reaction on both pleural effusions. ( info)

3/19. culture-negative endocarditis due to Chlamydia pneumoniae.

    We report on the case of a 54-year-old woman diagnosed as having culture-negative endocarditis (clinical and histopathologic evidence compatible with a recent episode of endocarditis). The responsibility of Chlamydia pneumoniae in this episode of endocarditis was suggested by a serological study and was then confirmed by the positive results of PCR and in situ hybridization tests with aortic and mitral valves tissues. To our knowledge, this is the first case of endocarditis due to C. pneumoniae confirmed by molecular biology-based techniques. ( info)

4/19. Abortion in woman caused by caprine Chlamydophila abortus (Chlamydia psittaci serovar 1).

    On a farm housing cattle and goats an abortion storm occurred affecting 50% of the goats during the lambing season 2000/2001. In one of three investigated caprine abortions Chlamydophila abortus could be identified as aetiology. During this time a pregnant woman (pregnancy week 19/20) had contact with aborting goats. She developed a severe generalized infection and aborted. The placenta contained Chlamydophila abortus shown by immunohistochemistry and PCR. The aim of the present case report is to alert medical doctors about the potential zoonotic risk of ovine/caprine abortions. ( info)

5/19. A casuistic immunologic response in primary and repeated chlamydophila pneumoniae infections in an immunocompetent individual.

    A casuistic immunologic response in primary and repeated chlamydophila pneumoniae infection is described. The primary C pneumoniae infection was documented as laboratory accident in late 1990. The immunologic response was mediated mainly through production of IgM antibodies with only a marginal IgG and IgA increase near the cut-off value. The second episode of respiratory illness in the summer of 1999 that was clinically compatible with acute C. pneumoniae infection was characterised by only increase of specific IgM antibodies detected by microimmunofluorescence, EIA and Western blot analysis. Remarkably, in the first episode of C. pneumoniae infection IgM antibodies were predominantly to 60 kDA and LPS antigens, whereas in the second episode they were to a 40 kDA protein and LPS. Non-specific polyclonal B-cell activation by Epstein Barr virus infection as well as other possible common causes of acute respiratory illness were excluded by routine serology. Noteworthy, the patient was able to respond adequately to other pathogens (e.g. cytomegalovirus) as determined by IgG EIA. The reason for the observed uncommon immunological reaction remains enigmatic. However, quick therapeutic interventions (due to awareness) or massive infection load in the primary infection might have had some suppressive impact on the maturation of the immunity. ( info)

6/19. culture and immunohistochemical evidence of Chlamydia pneumoniae infection in ulcerative pyoderma gangrenosum.

    A potentially contributing factor to the development and chronicity of pyoderma gangrenosum is infection with the relatively recently characterized human pathogen, Chlamydia pneumoniae. C pneumoniae is an obligate intracellular bacterium that can infect endothelial, monocyte, and smooth muscle cells and is associated with cardiopulmonary diseases. A case of serologically, polymerase chain reaction-positive, immunohistochemically, and culture-documented viable C pneumoniae organisms in a chronic pyoderma gangrenosum ulcer is reported, a finding that has not been described previously. ( info)

7/19. Extrarespiratory Chlamydia pneumoniae infection associated with immune disorder, hepatitis and renal disease.

    Chlamydia pneumoniae infection was diagnosed in an elderly patient with prolonged fever and hepatomegaly and no evidence of respiratory tract infection. Laboratory investigation showed hepatitis, eosinophilia, cryoglobulinaemia and the presence of antinuclear antibodies. It was concluded that C. pneumoniae may cause an acute extrarespiratory infection as well as stimulate immunological reactions. ( info)

8/19. Severe Chlamydia pneumoniae infection in a patient with mild neutropenia during treatment of Hodgkin's disease.

    Chlamydia pneumoniae is known to cause acute respiratory tract infections in the non-immunocompromised population. So far, no data about the incidence of chlamydial infections in neutropenic patients are available. Macrolide antibiotics are not considered to be first-line treatment options in neutropenic patients. We report the case of a patient with Hodgkin's disease who developed C. pneumoniae pneumonia during mild neutropenia. C. pneumoniae should be considered as a causative agent of pneumonia in neutropenic patients. ( info)

9/19. Chlamydophila abortus pelvic inflammatory disease.

    We report the first documented case of an extragestational infection with Chlamydophila abortus in humans. The pathogen was identified in a patient with severe pelvic inflammatory disease (PID) by sequence analysis of the ompA gene. Our findings raise the possibility that chlamydiaceae other than chlamydia trachomatis are involved in PID. ( info)

10/19. Outbreak and persistence of Chlamydia pneumoniae infection in an Italian family.

    We describe an outbreak of familial infection of Chlamydia pneumoniae, an etiological agent for respiratory tract infections. In a family member detection of C. pneumoniae on a pharyngeal swab by polymerase chain reaction was positive until four months after the onset of symptoms, despite a course of antibiotics known to be effective against Chlamydia species ( info)
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