Cases reported "neoplastic processes"

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1/3. Molecular genetic characterization of both components of a dedifferentiated chondrosarcoma, with implications for its histogenesis.

    Dedifferentiated chondrosarcoma is defined as a high-grade, anaplastic sarcoma adjacent to a low-grade malignant cartilage-forming tumour. Controversy remains as to whether the anaplastic and cartilaginous components are derived from a common precursor cell, or whether they represent separate genotypic lineages (collision tumour). Both components of a case of dedifferentiated chondrosarcoma were therefore separately investigated by loss of heterozygosity (LOH) analysis, comparative genomic hybridization (CGH), dna flow cytometry, and p53 analysis. Both showed p53 overexpression and an identical somatic 6 bp deletion in exon 7 of p53. Combination of the CGH and LOH results revealed that both components had lost the same copy of chromosome 13. These results provide compelling evidence in this case for a common origin, instead of the 'collision tumour' theory. Certain genotypic alterations were not shared. The anaplastic component showed severe aneuploidy, LOH at additional loci, and amplification and deletion of several chromosome parts. In contrast, the cartilaginous component had lost chromosomes 5, 22, 17p and part of 16p and revealed an amplification of 17q. The LOH and CGH results further demonstrated that the two components had lost a different copy of chromosome 4. Thus, a substantial number of genetic alterations have occurred after the diversion of the two components, indicating that the separation of the two clones, derived from a single precursor, was a relatively early event in the histogenesis of this case of dedifferentiated chondrosarcoma. ( info)

2/3. Introduction to colorectal cancer.

    OBJECTIVES: To provide an overview of colorectal carcinoma (CRC), including current treatment strategies for various stages of the disease. DATA SOURCES: research articles and textbooks. CONCLUSIONS: Despite screening methods for early detection of CRC, many patients present with late-stage disease and have a poor prognosis. The approval of irinotecan for CRC changed the approach to treatment, and there are numerous agents under clinical evaluation that may soon be available for the management of patients with CRC. IMPLICATIONS FOR nursing PRACTICE: Recent advances in molecular targeting have led to the development of new treatments for CRC. Because nurses will ultimately administer these agents, it is important to understand how these agents target CRC. ( info)

3/3. natural history of multifocal solitary fibrous tumors of the pleura: a 25-year follow-up report.

    We report this case with "multifocal solitary fibrous tumors of the pleura," which recurred at different sites in the left pleura at different time intervals over a span of 25 years, finally exhibiting features of malignant transformation. This patient was first seen in 1978, when she was 58 years of age, for episodic attacks of hypoglycemia and a mass occupying the entire left hemithorax. The operative findings and histologic appearance were that of a solitary fibrous tumor. ( info)

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