FAQ - Carcinoma, Signet Ring Cell
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What are the treatment options for person having both Sarcomatoid RCC & Signet ring cell Carcinoma of Stomach?


In June '07 we detected the Sarcamatoid Renal Cell Carcinoma (clear cell) cancer in the right kidney. Right radical nephrectomy was done and the entire kidney was removed. In Dec '07 we found that cancer had spread to lungs and liver. At the same time we discovered the presence of Signet ring cell carcinoma in the Stomach. We started Chemo regime (Docetaxel, Cisplatin and Fluorouracil) to treat Stomach cancer. Recently in March '08 when we did the scan after 3 rounds of chemo we found that the kidney cancer has further spread in the liver (biopsy confirmed this). We have stopped chemo now and our oncologist has recommended Avastin. Any recommendations? Any one who went thru something similar? Any and all help appreciated.
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check out this research group....someone one the message board might be able to help http://boinc.bakerlab.org/rosetta  (+ info)

Signet Ring Carcinoma in Colon Cancer?


Where can I get information on Signet Ring Carcinoma in Colon Cancer. I understand that this is not a common cancer. I am interested in survival rates, return of the cancer following surgery when no lymph nodes were involved.
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http://www.appendix-cancer.com/Signet%20Ring.htm

Hope this helps  (+ info)

What Is the prognosis for signet ring cell cancer?


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Signet Cell Carcinoma - Who has heard of this type of cancer? What are typical treatments?


My 53-year-old mother has just been diagnosed with stage 4 Signet Cell Carcinoma, and it has spread to her Lymph Nodes and Bone Marrow. They are trying to determine the primary source, but the "staining" that they are doing to her blood (they = pathologists) is taking longer than expected because the cells keep changing. The Ongologist is leaning towards her GI tract as the primary source, but they are trying to narrow down which part specifically...

She has also developed a blood clot on her lungs (which is apparently breaking up after we started her on strong blood thinners), and she has also developed hospital-acquired pneumonia.

The doctors have started her on Chemotherapy (she started on Friday), but we are all wondering:

1. Has anyone ever come across this type of cancer before?
2. Does anyone have any indication of success rates for treating this disease via Chemotherapy?
3. Can anyone suggest an alternate treatment (ie. homeopathy, natural remedies, etc)?
4. Does anyone have any indication of timing? (ie. How much longer we might have with her)

Any help/guidance/advice is welcome and appreciated (even if you do not have good news for us). We are realistic.

Thank you all.
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Signet cell carcinoma often occurs in the GI system and it is more aggressive than other cancers more often found in the same area. It is difficult to treat cancer not knowing the primary site. However, she has a stage 4 cancer regardless of the primary site and it is not curable. Success is measured by how well she responds to treatment. The only alternative treatments are clinical trials which may be difficult to find with an unknown primary. I'm sorry.  (+ info)

Can the monogram on a 10k signet ring be removed and replaced?


I inherited an old solid gold signet ring. The initials on the outside of it are not even close to mine and engraved rather deeply. Can I have them removed or filled in and replaced with mine?
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Absolutely!
Depending on how thick the ring's surface is, you might be able to have it polished down to a level surface and have it re-engraved. A good goldsmith could also make a flat gold plate to cover the surface of the ring, solder it on top of the ring and engrave it. Another possibility would be to have gold letters soldered/attached on top of the engraved letters.
Your goldsmith would be the best one to determine which technique would be the best for your ring.  (+ info)

Why is basal cell carcinoma the least invasive of all cancers?


Basal Cell Carcinoma (BCC) can develop into large unsightly skin tumors but the cells rarely metasize or spread to distant sites like malignant melanoma, lung cancer, colon cancer etc.
Is it that only certain genes are involved in BCC which mean they fail to become completely immature like other tumor cells, or is it they are more liable to be attacked by the immune system? Any other ideas?
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Simon - Great question! Sorry that the answer is not yet known. Most cancer research efforts have been directed towards the malignant tumors which rapidly invade the blood vessels and lymph channels making their spread easily, but not malignant basal cells of basal cell carcinoma (BCC). It may be genetic, as you mention, or the BCC cells may lack certain genes and/or enzymes which would allow the cells to survive in other body locations. It is NOT likely to be related to the immune system as microscopic examination of BCC lesions do not show the tissue changes of immune-type cells adjacent to or invading the BCC as they do with other tumors. Hence, the BCC spreads by ever-widening direct growth from the primary tumor without metastases but able to invade the toughest of nearby tissues, even bone. Might you be interested in such a research career in dermatopathology?  (+ info)

How do I use my signet ring to produce the seal?


I got a signet ring for a recent special birthday and i was just curious if there were any specific preparations that i need to go through before using it

Thanks
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You need to get hold of some sealing wax. Clean the ring with mild washing up solution to prevent it sticking to the seal....melt wax onto a surface, wait untill it BEGINS to set, press in seal, hold untill set...hey presto!  (+ info)

What is small cell carcinoma, and why is edema in the upper body a serious complication.?


A family member has small cell carcinoma being treated with chemotherapy in the lung/thoracic area, and recently has developed edema in the arms and chest (not sure specifics of where in the chest the edema is). What is this type of cancer and what is the concern with the edema when it develops secondary to the cancer? Thank You.
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oedema of the upper body is due to blockage (partial) of the superior vena cava (the main vein which drains the part of the body above the level of the heart). this is due to infiltration of the vein by the malignant tumour. its a bad prognostic factor.

as for small cell carcinoma, it is a highly malignant tumour of the lungs, and spreads rapidly. it also produces certain hormones that mimic hormonal imbalance states (paraneoplastic syndrome).

u can type in "small cell carcinoma" on wikiepedia and check the other details for urself.  (+ info)

How long does someone with stage 4 Renal cell carcinoma have?


My grandfather, 83, has stage 4 renal cell carcinoma. The cancer has spread to his lungs (several tumors on lungs), bladder, gall bladder, and the doctor said he could feel tumors all over. I just want a realistic outlook for his life expectancy. He will be receiving immunotherapy in a few weeks but his general practice doctor seemed to think he had weeks to a few months to live. His oncologist didn't give him a time frame. I just want to know what he is looking at. He already is having trouble breathing.
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No one knows.My wife has stage IV renal cell carcinoma and no one thought she would make it one year.It been a tough road, but shes still here 5 years 5 months latter.  (+ info)

What are some treatments for Basal Cell Carcinoma?


I think i have Basal Cell Carcinoma, And I'm going to the clinic Thursday, and i was wondering what i have to look forward to.. Like what they'll do to treat it.
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Basal Cell Carcinoma is a type of skin cancer. It is typically a very slow growing, non-invasive cancer and is treated very effectivly by excision. If the doctor believes the lesion to be suspicious of BCC, they will likely schedule a biopsy to confirm this, and then completely remove it by cutting it out and placing a couple of stiches on the wound.  (+ info)

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