FAQ - Diabetes Insipidus, Nephrogenic
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Is Nephrogenic Diabetes Insipidus similiar to Children's Diabetes or is it very different?

Nephrogenic diabetes insipidus is a disorder in which the kidneys produce large amounts of dilute urine. Dilute urine has a high water content, while urine that is lower in water is more concentrated. Normally, the kidneys control the concentration of the urine in response to the body’s need for water by absorbing water and returning it to the blood.

Nephrogenic diabetes insipidus is hereditary in males. It can also occur in people who take drugs such as lithium, demeclocycline, and aminoglycosides.

The gene that causes nephrogenic diabetes insipidus is carried on the X chromosome. Women with this gene can pass the disease to their sons, and it is usually males who develop symptoms. The body naturally produces an antidiuretic hormone (ADH), which tells the kidneys to return more water to the blood and concentrate the urine. However, in people with nephrogenic diabetes insipidus, the kidneys ignore this hormone and continue to produce dilute urine. When nephrogenic diabetes insipidus is induced by a drug, the drug damages the kidneys so they are unable to respond to the ADH.

The symptoms of nephrogenic diabetes insipidus are extreme thirst, called polydipsia, and the excretion of large amounts of dilute urine, called polyuria. When the condition is hereditary, these symptoms appear at birth. Infants who do not receive enough fluids to replace the water lost through the urine may become dehydrated. Prolonged dehydration affects all the body’s tissues, including the brain cells. Untreated, nephrogenic diabetes insipidus can cause brain damage and affect physical growth.

To diagnose nephrogenic diabetes insipidus, doctors evaluate the symptoms and test the blood and urine for levels of water and sodium. If you are an adult, your doctor will need to know if you take any medications that can cause nephrogenic diabetes insipidus. To confirm a diagnosis, your doctor will test the kidney’s response to the antidiuretic hormone (ADH).

There is no cure for nephrogenic diabetes insipidus. Treatment involves preventing dehydration by drinking water at the first signs of thirst. In infants and children who may not readily communicate their thirst, it is the responsibility of the adult to provide water frequently. Your doctor may also prescribe certain drugs that help with this disorder. With treatment, infants with nephrogenic diabetes insipidus usually develop normally.

If you or your child has nephrogenic diabetes insipidus, always make sure you carry water with you when away from home.

For more info visit my free website
http://www.reddiabetes.com  (+ info)

Diabetes Insipidus - neurogenic OR nephrogenic?

can you distinguish between the neurogenic and nephrogenic factors that result in the symptoms of diabetes insipidus?

Neurogenic DI is a condition in which the kidneys are unable to conserve water due to the resistance to the anti diuretic hormone,arginine vassopressin (ADH)
Nephrogenic DI is due to the insensitivity of the kidneys to ADH.
The condition is genetic.
The biggest risk is dehydration so the patients have to take large amounts of water and I mean LARGE.
Over the years there is a risk of problems with bladder or urethra due to the large amounts of water processed.  (+ info)

Diabetes Insipidus?

I am desparately trying to figure out why my 7 year old daughter still has accidents during the day. Someone suggested Diabetes because she is always thirsty. She had a urine culture and it came out normal. My question is whether or not Diabetes Insipidus can be determined through just a urine culture?

from reading the quote I included, it looks like a UA "can" determine DI. I would have thought that a blood test was required myself. I included the link; google listed a few others. good luck!

"A 24-hour urine collection for measurement of total volume, osmolality, and creatinine is sufficient to determine if you have DI. After that, additional tests are required to determine the type of DI. If the 24-hour urine volume you report is complete and accurate, it is very unlikely that you have DI of any type (unless you are very small i.e., weight less than 100 pounds). The upper limit of normal for a 24-hour urine volume for an adult is 50 ml. per kg. of body weight."  (+ info)

Do i have to take medication for central diabetes insipidus for the rest of my life?

I am suffering for central diabetes insipidus since 1988. I take medication two to three times a day sine 1988. What should i do?

You have to take it life long.  (+ info)

My two year old has just been diagnosed with diabetes insipidus any tips?

My 2 year old little girls that has had trouble sleeping has just been diagnosed with diabetes insipidus. Does anyone have a child with this and have any tips for me at all on how i can help her?

First, you need to become as knowledgeable as you can very rapidly. Go to WebMd.com and type in that term and read up on this condition and it will also have treatment recommendations there. You can also do research on MayoClinic.com - both of which are some of the most reliable medical websites on the internet. Knowledge is power and you will have to be the advocate for your child and to help make medical decisions and be able to understand the repercussions of those recommended treatments.  (+ info)

Can symptoms of Diabetes Insipidus disappear and then return?

My 20 month old had the typical symptoms of diabetes insipidus from birth (frequent urination and extreme thirst). Then at 5 months old they went away and were replaced with constipation which continued until she was 11 months old. Then again she was putting out high volumes of pale urine and drinking more water than I have ever seen a child drink. Now at 20 months she is back to being constipated and not drinking or urinating heavily. Doctors want to do a MRI but do not want to undergo such an evasive procedure if there is no diagnosis.

As a father of a large family I would be doing what the doctor says and fast. An MRI is the least invasive proceedure for internal examination. It's magnetic imaging not xray.I went with a grandaughtwer while she had it done for a faulty stomach valve which needed major surger eventually. It was nothing at all to be concerned about.
They may well be examing for a twist in the bowel and that needs finding.  (+ info)

Foods and herbs that help people with diabetes insipidus?

I want to know about foods and herbs that help people with diabetes insipidus.
Please Help

You need to stay hydrated and take your meds. There are no foods that can help with DI.  (+ info)

Is weight loss a symptom of dipsogenic diabetes insipidus?

My brief is "A 19 year old student has recently noticed that he has been much more thirsty and has been producing much more urine than normal. Although eating a high calorific, fast-food diet, he has also lost weight." And I have been led to believe that it is DDI. Any help appreciated.

yes it is. I have what your student has. It can be called several different things. it's refered to as Adult Growth Hormone Deficiency, also look under Pitutarty gland, and the name for the disease is called Insipidus Diabetes which means your lacking growth hormone. First they had me start out with a neuroligist and he took tests of the brain to see what happened. Then he sent me to an encronologist who specializes in Diabetes and she took blood work to see where my levels where. they found my levels were low and that I needed to get hormone replacements. If he has no insurance and needs replacements Eli Lily can get him on a Patients asst program where they pay for the drug. tell him to drink those Ensure drinks as they pack weight on. Start here and you will be on the right road.  (+ info)

Can diabetes insipidus lead to seizures?

I understand through dehydration it is very possible, but I would really appreciate any input I can get on this.

Nephrogenic diabetes insipidus (NDI) is a disorder characterized by an inability of the kidneys to remove water from the urine. The main symptoms of NDI are excessive thirst (polydipsia) and excretion of large amounts of watery urine (polyuria). Individuals with NDI must drink large amounts of water to compensate for the loss of water in the urine. As a result, a person with NDI must urinate more frequently than usual.

There are two different forms of NDI, inherited and acquired. Inherited NDI is a rare disorder which is present from birth. Usually, only men have NDI. Women may have varying degrees of symptoms including increased thirst and the need for more frequent urination. If infants and young children are not treated for their NDI, they will lose too much water from their body. These periods of extreme water loss (dehydration) may lead to brain damage and, in rare cases, death. If NDI is diagnosed and treatment is started in early infancy, and if periods of severe dehydration are avoided, NDI should not affect a person’s intelligence or how long they will live.

For more info visit my free website
http://www.reddiabetes.com  (+ info)

Help with the nursing process on diabetes insipidus?

I was wondering what were somethings that I could put down for each part of the nursing processing dealing with this disease?

Assessment: assessing for signs of thirst or dehydration
diagnosing: Im not sure what to put for this? Like the diagnostic tests that can be ordered?
planning: like planning they have lots of fluids and the decrease risk for dehydration and maintaining a healthy diet and getting exercise?
Implementation: Im not sure
Then Evaluation:

Im not really sure how to piece this all together in these categories any help would be nice. Thanks

Assess for signs of dehydration and thirst: Check the patients skin tone, they will have loose skin and sunken dark eyes if dehydrated. Also, their urine will be very dark, and they may have a dry mouth and dry sore lips. Use your skills to make an assessment when you see them. Then you can use clinical diagnostic methods......
Diagnosis: The glucose intolerance blood test, also sugar levels in the urine.
Planning: Regular meals, probably 4-5 times daily, plenty of fluids etc.
Implementation: Write up a care plan for patient, explain to them what to do
Evaluation: See patient in few weeks to retest blood and urine and to see if they look and feel better. Question them on compliance.

Hope that helps, good luck!   (+ info)

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