FAQ - Factor Xi Deficiency
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is vitamin b1 deficiency a large contributing factor to a hangover?


I read in an internal medicine book that alcohol prevents absorption of vitamin b1 into the body. Since deficiency of vitamin b1 prevents the metabolism of carbohydrates, which are a source of energy for the body, I was wondering if the inability of the body to metabolize carbohydrates contributed significantly to the generalized weakness of a hung over person.
I am also aware of the impact of fragmented sleep of a drinker, but am looking for a relative comparison between several contributing factors
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How does the deficiency of factor X111 result in prolong PTT but bleeding risk is not appreciable?


What are you looking for; specifics as in the pathophysiology or examples? Are you familiar with Von Willebrand's disease? Add more info on what you want.  (+ info)

what is factor 8 deficiency in blood & how much it is necessary for operation?


Hello, can you please say how is it curable
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My mother has Factor V Leiden Blood Deficiency and I want to go on the contreceptive pill...?


My mother has factor v leiden blood deficiency and i read that if you are related to someone with this, even if you have shown no signs, you have to take certain steps to avoid it. The problem is one of these steps was not go on the contreceptive pill but i want to to avoid getting pregnant and so i was wondering if there was another form of contreception (other than condoms) that will protect me from getting pregnant as well as not give me this deficiency.
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I have the injection which you get every 11-12 weeks or the implant every 3 years.  (+ info)

Protein S deficiency linked to Factor V Leiden?


Does anyone know if these two are related? I was told I may have the protein deficiency, and when I looked it up, it mentioned the other one. What are the chances I have both?
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Both of those deal with your coagualation pathway in your body. And basically what that is a whole bunch of signals that work togethe to form a clot in your body. When working correctly, they only cause a clot to form when there has been damage to a blood vessell. Protein S is one of the signals that tells another signal (with the help of other things) to shut off. So protein S acts on factor 5. The other signal that works together with protein S to shut off factor 5 is protein C

A deficiency in protein S is not the same as Factor V leiden. Factor v leiden is a mutation that causes factor V (Roman numeral 5) to completely ignore protein C.

So if you can keep that all straight, sorry it's so confusing. Protein S and Protein C work together to shut off Factor V. If they don't shut it off, then your body might randomly clot. If you're deficient in protein S, then your body can't turn off factor V, which would be in your case. But in Factor V leiden, you have enough of everything, it's just your Factor V doesn't listen to Protein C.

I had to learn this pathway for school, and it is SO confusing, but if you wanted to see how they directly work together I included some refrences at the bottom.

Best of luck!  (+ info)

What is factor XI, is it some sort of blood disorder?


Factor XI itself is not a blood disorder. However, lack of it would most definitely be a blood coagulation disorder.

We all take our blood coagulation for granted but the body that we've been given, if it's a "normal" one, is a total miracle in and of itself.

The blood coagulation cascade is VERY difficult to explain to a layperson who has no physiology education. I'm guessing that you have not had courses in anatomy and physiology? If you have, you'd understand why this question is rather difficult to answer. I'm certainly not trying to offend you because not that many people understand this information anyway. It's not a matter of whether someone is intelligent or not but rather a matter of accumulated knowledge of how the body generally works. Having said that, let me give you just a brief and very general bit of information about the blood cascade.
The clotting factors, as you know, are VERY important to us because, without them, we'd all bleed to death from a cut or a wound. Our bodies want to keep the blood in a liquid state inside the body but if it starts leaking, we want that leak to be repaired and the body does it's own repair work as long as it has the right tools. The different clotting factors in the cascade are those tools. Those tools, however, must work in a certain pattern in order to be effective. Factor XI is one of those tools Though the process of coagulation (blood clotting) seems very simple, in reality it is VERY complicated. Most of it starts in the liver and involves numerous steps, proteins, enzymes, vitamins, hormones and minerals.
So, no, factor XI is not a blood disorder but without it, yes, it is a dyscrasia and a very serious condition.
Take a look at the Source below for an excellent explanation of the whole process. This should give you some vast knowledge of the subject.
I hope this helps.  (+ info)

I have quite bad roseacea on my face, back, & neck. Is lipase deficiency a factor for causing this disease?


I have rosacea also. My empathy.

I have it under control at this point and for some time, and do not take anything for it, knock on wood. Who knows next month. Years ago I tried tetracycline which, yes, cleared it up but messed up my digestive system badly. If you do take antibiotics, remember to replenish your friendly bacteria with acidophilus supplements or such like!!! I haven't taken antibiotics for rosacea for at least a decade.

I'm sure you know all this but of course i never drink alcohol which is the worst thing. Ditto for the hot-type of spicy foods. (It's ok to eat nice, savoury spices in food). Saunas, or really hot, steamy showers. Darn because i love those!

Also, I try to eat relatively healthy--protein, lots of vegetables, brown rice, fruit, and other carbs too. I try not to eat lots of white starches (white breads, cakes, white rice etc) and sugars, but i haven't forbidden them at this point. I try not to get too obsessive about it. :)

But on to the subject of ***LIPASE***
You could try taking digestive enzymes:
Some people with rosacea have indigestion, especially after eating fatty foods. One study found a deficiency of the pancreatic enzyme lipase, an enzyme that helps to digest fat.

When the rosacea patients in the study were given pancreatic enzyme supplements with meals, their symptoms of indigestion and rosacea both improved.

B Vitamins
Inadequate riboflavin, caused by insufficient dietary intake or poor absorption in the digestive tract, may be associated with rosacea.

I have discovered that i have food intolerances and have benefited greatly (!) from cutting out those foods that i don't tolerate well. (One example is dairy).

Food Intolerances
Some alternative practitioners have found clinically that certain foods may be associated with rosacea symptoms. Foods may cause the release of chemicals that dilate blood vessels and cause flushing.

An inexpensive and effective way of identifying food intolerance is through an elimination and challenge diet, which involves removing allergenic foods from the diet for one to two weeks then systematically introducing them into the diet to isolate the foods that cause reactions. Supervision by a health practitioner is recommended.

Also, I know that if i'm feeling really stressed that a flare-up is more likely. You know how when you're stressed, angry, or upset blood rushes to your face. I try to be aware of how i'm feeling, and if i'm upset I try to write it out or talk it out. At least acknowledge it to myself. (This is good for me, and happens to be good for my rosacea also).

Stress relief has helped me a lot. When i'm really stressed, i try to lie down undisturbed and tense and then relax each part of my body--one at a time. Starting from the feet and ending w the head. (It's called progressive relaxation).

Other things you can try if you want at some point:
Personally I haven't tried any of them except sometimes i take and have taken zinc (and drink chamomile tea).
Niacinamide Cream
Aloe
Chamomile
Betaine hydrochoride
Selenium
Zinc  (+ info)

What could be a trigger factor of multiple sclerosis?


There are a few theories about what could trigger multiple sclerosis:
Vitamin D deficiency, some latent virus in the body, or a prion.
What is your opinion?
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Many investigators believe MS to be an autoimmune disease -- one in which the body, through its immune system, launches a defensive attack against its own tissues. In the case of MS, it is the nerve-insulating myelin that comes under assault. Such assaults may be linked to an unknown environmental trigger, perhaps a virus.  (+ info)

Factor XII Deficiency / Coagulation?


I have been on the web, and I'm really confused.

Can anyone help me out please

My Factor XII Assay was 31%, and as it happens everytime I fly I have all the symptoms of DVT, but I don't have it (Scans Confirmed), also everytime I have a blood test I am asked to stop/cut down drinking (I drink maybe a bottle of wine 3 times a year) as I am going to end up with Liver Disease.

I have checked on the web, and it does say that really I should wear a Medic Alert bracelet, but I have no idea what to do. Pathologist just said "You have a Factor Xii problem, normal range is 50, yours is at 31"

Anyone shed any light for me please please!!
Sorry I'm new to asking questions, and I have posted it to the wrong place, apologies everyone.

Asprin makes me extremly sick and very lethargic
No, I didn't drink whatsoever before the test, its very rare I do!
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alcohol thins the blood and if you have ay problems then if you were bleeding it could cause a slower coagulation of the blood

Would need more symptom and medical details to give any advise  (+ info)

What is Factor 8 deficiency?


Hemophilia A is the most common type of hemophilia. It is also known as factor VIII deficiency or classic hemophilia. It is largely an inherited disorder in which one of the proteins needed to form blood clots is missing or reduced. In about 30% of cases, there is no family history of the disorder and the condition is the result of a spontaneous gene mutation.

Approximately one in 5,000 males born in the United States has hemophilia. All races and economic groups are affected equally.

When a person with hemophilia is injured, he does not bleed harder or faster than a person without hemophilia, he bleeds longer. Small cuts or surface bruises are usually not a problem, but more traumatic injuries may result in serious problems and potential disability (called "bleeding episodes").

There are different levels of hemophilia: mild, moderate, and severe:

• People with mild hemophilia (6% to 49% factor level) usually have problems with bleeding only after serious injury, trauma, or surgery. In many cases, mild hemophilia is not discovered until an injury or surgery or tooth extraction results in unusual bleeding. The first episode may not occur until adulthood.
• People with moderate hemophilia, about 15% of the hemophilia population, tend to have bleeding episodes after injuries. They may also experience occasional bleeding episodes without obvious cause. These are called "spontaneous bleeding episodes."
• People with severe hemophilia, about 60% of the hemophilia population, have bleeding following an injury and may have frequent spontaneous bleeding episodes, often into the joints and muscles.

Factor VIII deficiency, dysfunctional factor VIII, or factor VIII inhibitors lead to the disruption of the normal intrinsic coagulation cascade, resulting in spontaneous hemorrhage and/or excessive hemorrhage in response to trauma.

Hemorrhage sites include joints (eg, knee, elbow), muscles, CNS, GI system, genitourinary system, pulmonary system, and cardiovascular system. Intracranial hemorrhage is most common in patients younger than 18 years and can be a fatal event.

Patients who acquired HIV, hepatitis, or other viruses suffer from maladies associated with those infections.  (+ info)

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