FAQ - Genetic Predisposition to Disease
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what is the genetic predisposition for a child of a schizophrenic parent to develop the disorder?

In terms to genetic risk, children of a schizophrenic parent are ___________ times more likely to develop the disorder than members of the general population?

IT IS VERY LOW. I dont remember exactly but it is less than most people think AND they think it is primarily determined by environmental causes, upbringing et al anyway

a healthy family reduces the possiblity by more than 86%

schizophrenia.com  (+ info)

I need to pick a Genetic disease to do a project on. Any suggestions?

I need to pick a genetic disease to do a biology project on. I don't know which one to do though. I can't do any of the really common ones like down syndrome though. So any suggestions?

There are many to pick from:

Sickle Cell Anemia
Cystic Fibrosis

Above are two to get you started!  (+ info)

What is the genetic basis for Parkinson's Disease?

I am currently working on a project for my biology class on parkinson's disease. in one of the boxes i have to put the genetic basis for PD.
(for example, is it sex linked, controlled by one or multiple alleles, non disjunction, random mutation of a certain gene, etc.)
I can't seem to find these answers anywhere.
Any answers or suggestions of sites would be great, thanks.

The jury is still out for the full genetic basis for PD.

The latest concept is that Parkinson's disease is genetic and can remain dormant for generations. One reason that PD was not thought to be primarily or strictly genetic in nature was that sometimes many generations were skipped. It is possible that other factors have to act as the trigger. Environmental, medications, heavy metal exposure and the like.

I put the best link last but read down first as the expository info will be in the earlier links.

The first link is for two studies completed in 2008 by two researchers from the Mayo clinic where PD studies have been conducted for many years.

In one study a mutation of LRRK2-R1628P has been traced back to 2,500 BC. LRRK2-G2385R has been traced back 4,500 years.
Another study found that LRRK2-R1441C can increase the chances of developing PD by 10X.


Next let's go to the LRRK2 (leucine-rich repeat kinease2) autosomal dominant mutation which you can read about here for starters because it has been identified in almost 5% of PD cases:


There is a study currently recruiting for a LRRK2 study in Maryland:

Glucocerebrosidase gene
GBA mutations (N370S, L444P, 84GG, IVS+1, V394L, and R496H) that are most common among Ashkenazi Jews

and GBA-Gly2019SER here:

A study published in 2007 indicated that genetic mutations were 2X as common in YOPD (Young or early onset Parkinson's Disease) and in people of Jewish Ancestry - specifically Ashkenazic)

Here is an abstract link about DJ-1, an autosomal recessive linked to PD. The abstract also references PARK6 and PARK7:

The best gene data base is here - it is a public and you can link to the site to see it:

In this chart you will see the gene, the number of reports and ethnic groups
Naturally it begins with LRRK2. PARK2 followed by SNCA, CYP2D6, PINK1, MAPT, UCHL1, MAOB, PARK7 and APOE
It then lists the top 10 genes with the most variants followed by the top 10 with the most negative reports.
There are several other comparisons you can do at the site, it is amazing. Check it out.

While it is true that more men than women develop PD that may be because of a bioprotectiveness of estrogen. Which of course ends at sometime with menopause.

You should probably search for Chinese - HAN - gene - Parkinson's disease. You might find the rest of the answer which you need. There are also several familial studies. I have read the abstracts but not the full studies.

Here are a few which should help:

Here's a familial study from Italy but it is older, 2003:

To properly search just enter each term with Parkinson's disease and you will find a host of abstracts and some articles about the abstracts. You will not find definitive answers because they aren't there yet. Pd is a complicated disease.  (+ info)

How can viruses be used for curing genetic disease?

how might viruses be used to cure some genetic disease?
Is it Mutations?

Not just any virus can be used, only certain types of viruses that have the ability to insert DNA into the genome of their target. One example of this is HIV which turns its RNA genome into a DNA genome, then inserts it into a host cell in order to have the host cell make all of its proteins for it. Of course HIV might not be the best choice but there are other viruses that are similarly able to insert DNA into the host.

Many genetic diseases result from simple changes in the sequence of a single gene. For instance a small segment may be deleted or a couple of the base pairs can be changed resulting in an altered protein. If there was a way to insert a correct copy of the gene into individuals with such a mistake, it could be possible to cure the disease.

Viruses that insert DNA into a host cell are promising tools for doing just that. The way the process works is by taking out all of the genetic material of the virus that allows it to cause disease while leaving all the genes that allow it to insert DNA into the host . Then, in place of the virulent genes that were taken out, you insert the correct sequence of the gene you want to fix. If everything goes well, when you infect an individual with this new virus, instead of virus genes being inserted, instead the correct copy of the gene will be swapped in for the incorrect copy, restoring proper function. However, one of the main issues with this technology is that it is hard to control where the virus inserts the new DNA and if it is not inserted exactly where the incorrect sequence is, the bad gene may not be corrected.  (+ info)

During blood transfusions if the donor has a genetic predisposition to an illness does this pass on?

If the donor is not aware of their complete genetic makeup, such as lupus, narcolepsy, cancer, etc. Can this pass on, or does the receivers body filter it out?

Red blood cells do not contain a nucleus, meaning that there is no genetic information being passed on to the recipient of a transfusion, only the blood. Meaning that there is NO chance of you getting a genetic illness from the donor

But, here in the UK you are not allowed to donate blood if you have any of the afore mentioned illnesses you talk about, unless its urgently needed by a family member and you are the only option. hope it helps :)  (+ info)

If a disease is genetic, does that mean that everyone with that disease is related?

If you go far back enough, that is?

For example; the blue eyed gene was supposedly traced back to one single genetic defect, which was carried forth, which makes everyone with blue eyes, or blue eyed family members, distant genetic relatives.

Would it be the same for all genetic illness?

That would be the case for some genetic diseases

Other genetic diseases are caused by random mutations of chromosomes. During meiosis, many deletions and insertions occur into the DNA which make it unique. These are all random. Some of these can cause genetic diseases or disorders. So it is not inherited, but is a random event when the genes are made. However it can also become inherited to the children of this person

But yes, with some genetic diseases, everyone would be (VERY) distantly related at some point in their history  (+ info)

Is it true that you will inherit a genetic disease if both your mother and father have the disease? Why?

question # 2: Is it true that you cannot inherit a genetic disease if neither you mother nor your father show any signs of having that disease? Why?

Remember- very very few diseases are wholly genetic. Almost all depend upon environment to trigger the susceptitbility.  (+ info)

What is a fatal disease that strikes quickly and is genetic?

When I say "strikes quickly" I mean that it takes less than a week for the person to die.
When I say "genetic" I mean hereditary (passed down from mother/father/aunt/uncle/grandparents/etc to child).

Is this another writing project?  (+ info)

What are some of the causes of non genetic or "acquired" mitochondrial disease?

I have been told that there are cases of mitochondrial disease that are non-genetic and that other diseases, environmental factors, etc. can cause mitochondrial dysfunction. What are some of the more common factors?

Heavy metal toxicities (lead, mercury, arsenic, etc.) are probably the most common environmental cause.

Chemical toxicities may also have the potential to damage mitochondria.

Additionally, micronutrient deficiencies (e.g. iron deficiency, etc.) can damage mitochrondria.

Lastly, any excessive source of oxidatived stress or deficiency of antioxidant potential can damage mitochondria.  (+ info)

I think I have a possible genetic disease that has to deal with my teeth?

Ever since I was 13 or 14, I went to the dentist and he told me that I may have an unusual genetic teeth disorder, but I can't remember what he said. Well anyway, I brush my teeth daily but they never get white, and I'm showing signs of gum disease, My dentist years ago asked me about my father and I knew that he had teeth issues also. Now i don't know if its genetics and or something else. But my teeth don't get white at all, and I am showing early signs of gum disease. Any ideas?

the risk for gum disease can certainly be linked to family. However that doesn't mean that if your parents have gum disease you can't do anything about it. It just means you have to clean better and it will go away.

Gum disease is just the reaction of your gums to plaque (made form bacteria) growing on your teeth. Technically if you cleaned it all away every day you would never have gum disease, not matter how many of your fathers fathers had it.

tooth whiteness is something entirely different. Brushing your teeth generally doesn't make them whiter unless they are covered with filth. The colour of your teeth is the natural colour of your teeth. See a dentist to find out how you can make them whiter. The answer will be bleaching or veneers.  (+ info)

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