FAQ - Granuloma, Respiratory Tract
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In terms of salt and water secretion, why this results in thick mucus in the respiratory tract?

The genetic defect in cystic fibrosis affects the chloride channels in secretory cells.

Actually, this still appears to be a topic of debate among scientists who study Cystic Fibrosis (CF). It appears that there are two hypotheses. According to the "compositional" hypothesis which some scientists subscribe to, the salt secretion helps your respiratory tract form a chemical barrier against infections, and the changes in the CF gene disrupt this balance. According to the "volume" hypothesis, the key is how much liquid is secreted by your respiratory tract. According to this hypothesis, the accumulation of mucus as well as the the infections that arise from CF both have a single root cause: the change in how much "Airway Surface Liquid" is secreted in your respiratory tract.

According to this hypothesis, what happens normally is that your airway and lungs are in effect being perpetually "washed" by a continuous secretion of liquid. This not only keeps mucus from building up, but it also keeps bacteria from sticking to your airways and having a chance to grow. The changes in the CFTR gene affect a number of systems in your body, but one of them is a reduction in the rate at which you produce this liquid, which not only gives mucus a chance to build up in your lungs, but it also gives certain bacteria a chance to stick and thus grow and reproduce.

It's worth mentioning that this comes from a paper by a researcher named Robert Tarran who studies Pulmonary Medicine at the University of North Carolina. The results of this paper seem to favor the volume hypothesis over the compositional hypothesis. He did this by showing that by introducing substances which affected salt concentration but didn't change the volume of airway liquid weren't as affected as those which changed the volume of airway liquid.

I found this paper by going to the OMIM page for Cystic Fibrosis (first link). "OMIM" stands for "Online Mendelian Inheritance for Man", and is a database produced by the national Library of Medicine (second link). It's intended primarily for researchers, so the content, though high quality, is often very technical. The paper by Robert Tarran is the third link.

For a less technical view on the subject, your best bet is probably the Cystic Fibrosis Foundation (fourth link). This route is very accessible, but they tend to focus more on generalities, so for specific questions on particular disease factors you might need to do a little research and follow links on particular researchers or research centers. Fortunately the "research overview" section of their site offers plenty of places to start.  (+ info)

what are the fungi that most often cause disease in the respiratory tract?

coccidiomycocis, aspergillosis, and blastomycosis  (+ info)

Whar is the microorganism in respiratory tract snd digestive system ,pls give its disease microbe causing tran

microorganism found in the respiratory tract and digestive system and give its disease microbe causing sexually transmitted disease?

That'd be one mean bug.  (+ info)

Compare the epithelial cells seen in the lining of kidney tubule and the respiratory tract?

please help me


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is upper respiratory tract infection (URTI) is the same or similar with atypical pneumonia?

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I feel I am most susceptible to respiratory tract infections.Pl tell me how to increase my immunity.?

Stop smoking if you smoke. Find out if you have asthma and/or allergies & take the proper medication if you do. Dust & vacuum frequently; both contribute to respiratory problems.  (+ info)

Can you die from Infections of the respiratory tract, sinuses, kidney, ear, or skin?

Yes, if the infection is severe enough and goes untreated, it can be fatal. Everyones immune system is different, some have a higher tolerance than others. If you have an infection, see a Dr., its not worth the risk. Good luck!!!  (+ info)

how could a respiratory tract infection result in respiratory failure?

infection -- bacterial
failure -- happens when the blood ph becomes acidic and goes down to 7.25 and below.

so to answer the question, never had a case wherein a patient who had respiratory tract infection, had respiratory failure. most likely, people with COPD are at risk for respiratory failure. but i am guessing that you CAN risk respiratory failure because of an infection -- due to hypoventilation.  (+ info)

what is the nature of respiratory tract infections?

I'm not sure what you mean by "nature" of RTI but I'll do my best. RTI is a term used for any infection that affects the respiratory tract - being the nose, throat, bronchi and lungs. Upper RTI is what you would call a "head cold", bunged nose, sinuses, sore throat, etc. Sometimes the eucasian tube gets blocked. That is a drain tube which joins your inner ear to the top of your nose. It allows air pressure to equalise in your inner ear and if it blocks you can feel as though you've gone deaf in one or both ears. Lower RTI is more of a chesty cough, when you get phlegm, coughing and wheezing. It is an infection affecting the lower part of the respiratory system, mainly the larynx (lower throat), bronchus and lungs.

RTI will usually be a short lived infection, but can be acute (severe and sudden) or chronic (long term). Regular RTI's are classified as COPD/COAD (chronic obstructive pulmonary/airway disease). This is common in smokers and those with long term exposure to poor atmosphere.

RTI can be caused by viral infection, bacterial infection or as a result of weaknesses in the body (poor lungs) and by smoking and exposure to poor atmosphere (i.e. dusty)

It's a bit of a potted history. hope it answers your Q  (+ info)

Nuva ring and respiratory tract infection-anyone?

Has anyone gotten an upper respiratory tract infection while on the Nuva ring? I think I may have one, as I have been coughing to death for about 2 weeks, and coincidently have been on the NR for about 3.

Anyone have to stop using it because of this? Anyone had a Dr. say anything about it?


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