FAQ - Huntington Disease
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huntington disease?

how is huntington disease tranmitted genetically what are the gene called basically?

American doctor George Huntington first described the disorder in 1872.
Huntington's disease is a disorder passed down through families in which nerve cells in the brain waste away, or degenerate.
Huntington's disease is caused by a genetic defect on chromosome #4. The defect causes a part of DNA, called a CAG repeat, to occur many more times than it is supposed to. Normally, this section of DNA is repeated 10 to 35 times. But in persons with Huntington's disease, it is repeated 36 to 120 times.
As the gene is passed on from one generation to the next, the number of repeats - called a CAG repeat expansion - tend to get larger. The larger the number of repeats, the greater your chance of developing symptoms at an earlier age.  (+ info)

What are the chances of my nephew having Huntington's disease?

My nephews dad's mother has severe Huntington's disease, my brother in law doesnt yet have any sighns that he may have it but what are the chances of my nephew having it as he gets older? It is a disease that is passed on to your children and that some can have the gean without having the disease. The doctors wont be able to tell if he will get it until he is older. He is only 3 months right now.

Your nephew right now has a 25% chance of inheriting HD since his father is not showing any symptoms at this time. Should his father start showing symptoms then your nephew's chances go up to 50%. Clinical testing is one way of being told you have HD that is where a doctor checks you over after symptoms start. There is a blood test that will tell you if you carry the gene for HD which is 90-99% effective. However you have to be 18 years old before you are able to test for HD because of the complications of depression and suicide that can happen if the person knows they carry the gene.

Inheriting HD from a Mother a person has somewhat better odds of not inheriting the disease as a female passes on a lower CAG repeat than a male does. But that does not mean that the mother passed on enough of the CAG repeat to place her child in the gray area. This is where you might not develop HD but can pass a higher repeat to the child causing them to have HD but the parent never does.

Now the father or male can pass on a higher repeat to his child which is usually where Juvenile Huntington's Disease steps in. Due to the higher CAG repeat children are able to start symptoms and have a life span of about 15 years where an adult onset has 20-25 years. There have also been cases where a Mother passes on HD to her child so don't think it cannot happen, it does just not as often.

I wish your brother in law and his family all the best.  (+ info)

Is it possible to inherit huntington's disease from grandparents, two uncles and two aunts?

My dad is the only member of his family that does not have huntington's disease. His parents, two sisters and brothers all had the disease.

Huntington's is caused by a gene. Anyone who has the gene will have the disease, although the symptoms may not appear until later in one person than in another.

My (admittedly limited) knowledge of genetics tells me that if both your dad's parents have/had Huntington's, then your dad does, too, whether or not he has begun to show symptoms.

It is possible that you will inherit it from your dad, but by no means is it certain. You and your dad both need genetic testing ASAP. Good luck.  (+ info)

Are people with Huntington's disease dangerous to others?

There's a guy who lives across the street from me and my husband, who has advanced Huntington's disease (twitches, mumbles, yells at people who are not there, etc). He's been coming to our home several times in the past weeks, knocking on our door, looking inside my car, and even trying to break in a week ago!

I haven't been able to find out anything about if people with Huntington's Disease are likely to be aggressive and/or cause harm to others due to their hallucinations. He has SEVERE hallucinations (he thinks he owns our home and rents it to us).

Anyone know anything????
His power of attorney lies with his brother... who has not been seen by us or any of the neighbors in months. No one lives with this guy, no one cares for him, he cannot drive, and our neighbors told us he has rats and other vermin in his house. No one wants to take responsibility for him.

We've called the cops two times now, because we felt threatened by him roaming around and following me home.

The police told us all we could do is keep calling until a case gets built up against him, so that he will get reviewed by a judge to go to a home.

We're just scared he may take it too far one day and try to hurt us or another neighbor.

Advanced Huntington's can indeed cause all the symptoms you describe.

It sounds like this man has progressed well beyond the point where it is safe for him to live alone.

It's appalling that the police don't seem to be doing anything about it.
If the man is out raging and wandering again, try calling an ambulance and reporting that he is in distress and needs medical attention.

Meanwhile, look in your local yellow pages under the city/county/state goverment listings. See if there is a hotline for senior services or mental health.
If not, try calling the hotline for child abuse.
Eventually you should get a social worker who will know how to get the man some help.

Good luck.  (+ info)

What kind of results are you looking for in prenatal testing for huntington's disease?

And also not just prenatal but confimatory testing and presymptomatic testing for huntington's disease. Help me please.

What you're looking for is a dominant autosomal mutation on chromosome 4. What you're hoping for is a negative result. Anybody who carries this gene mutation is genetically destined to die a horrible death as their nervous system slowly self-destructs. The worst part is, the symptoms start around age 40, after a lot of Huntington's sufferers have married and have had children. If you do prenatal testing for it and you find out that your child is a carrier, that means either you or your spouse has it.

Huntington's is a pretty hellacious diagnosis, and it's one of those things that you probably don't want to know about too far ahead of time because it dooms you. Do you want to be 25 and know that in 15 years time you will begin a 15 year decline that will eventually kill you? At the same time, do you want to have a kid only to find out later that you have the gene, meaning your kid has a chance of also carrying the gene?  (+ info)

Is it possible for a person to have two dominate alleles for huntington disease?

If this is possible than would they have a 100% chance of passing huntington disease on to their children?

I don't think so, I am not sure one person can have a100% chance.  (+ info)

What specific mutation causes Huntington's disease?

I need to know which specific mutation causes Huntington's disease, and on which chromosome the mutated gene is found on? Any help would be appreciated.

it is caused by a mutation in a protein called huntingtin found in chromosome 4. the nucleotide bases in that chromosome start repeating the pattern CAG too many times near the end. If the repetition is more than 40, then the person is bound to have Huntington's disease sometime in their life. If you have a lot more than 40, then you get the disease earlier and it also kills earlier.

plz answer my question.
http://answers.yahoo.com/question/index;_ylt=AiatfE3cTGki3AGNeZeIzdsjzKIX;_ylv=3?qid=20090524110631AAu1SeM  (+ info)

How at risk am I for getting Huntington's disease?

My Mother had Huntington's Disease while she was alive. I am wondering how at-risk am I? I am the youngest of 3 children my mother had and am wondering how likely it is that I will eventually get it? I am 20 and to my knowledge I don't have any symptoms yet.

This depends. Huntington's is not simple. It tends to go mother to son and son to daughter, it can skip generations, you can be a carrier (you have the gene, not the disease) which is most likely, and there is adult, juvenile, and infantile. You do not just get it, if you have it it's been there since you were a zygote and you would develop symptoms depending on what particular one you had. My grandmother had adult, who gave it to my father (who died before he developed any symptoms), and I have juvenile Huntington's. If you are over 18 you can get tested, nothing can be done but it is something you should do if you ever want kids or already have them.  (+ info)

Are there any symbols associated with Huntington's disease?

I am doing a brochure for Huntington's disease and I need a picture for the front page but don't know what to put down.

With permission, a family affected by the disease may be willing to let you portray their photo and or "Hope For A Cure"  (+ info)

How quickly can Huntington's disease kill you?

If you've been diagnosed with Huntington's disease, how quickly could the disease itself kill you? Or, how quickly could a symptom kill you? (Such as muscle spasm could cause you to fall down the stairs?)

That kind of question/thinking can kill you very quickly; a better question for you to ask is: how long can I live with Huntington's?

Depression is one of the major causes of deaths by Huntington's, and the more resources you utilize to avoid succumbing to that treatable concomitant disease, the longer your chances of living with Huntington's.  (+ info)

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