FAQ - Hypogonadism
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I have been checked and found out to be low in progesterone. I have taken profasi and pregnyl injections last month still no luck. Been trying to get pregnant for two years now,was on clomid from nov 2005-oct 2006,stopped when taking injections.
When should i go for check up to check if the injections increased my progesterone level?
Thanks for your anticipated assistance.

i don't know about the timing to get checked, but as an addition you could try any of the otc progesterone creams. i'v known of people who it helped with their cycles.  (+ info)


what is solution

Hormonal preparations are available for men and women. Estrogen comes as a patch or pills. Testosterone can be given as a patch or via injection.

For women who have not had their uterus removed, combination treatment with estrogen and progesterone is often recommended to decrease the chances of developing endometrial cancer. In addition, low dose testosterone can be added for hypogonadal women with a low sex drive.

If there is a correctible cause of hypogonadism (e.g., a pituitary tumor), medication may be given (particularly for prolactinoma) or surgery and/or radiation therapy may be required. Injections or oral medication can be used to stimulate ovulation. Injections of pituitary hormones may be needed for men with hypogonadism to produce sperm. Therapy may also target nutritional, infectious, or other causes of the problem.

Hypogonadism is most often treated by replacement of the appropriate hormones. For men this is testosterone. For women estradiol and progesterone are replaced. Some types of fertility defects can be treated; some cannot.

Medical Care: In prepubertal patients, treatment is directed at initiating pubertal development at the appropriate age. All such treatment is hormonal replacement therapy. Although the simplest and most successful treatment for both males and females with either hypergonadotropic or hypogonadotrophic hypogonadism is replacement of sex steroids, in hypogonadotropic hypogonadism, the therapy does not confer fertility or, in men, stimulate testicular growth.

An alternative for men with hypogonadotropic hypogonadism has been treatment with pulsatile LHRH or hCG, either of which can stimulate testicular growth. Since such treatment is more complex than testosterone replacement, and since treatment with testosterone does not interfere with later therapy to induce fertility, most male patients with hypogonadotropic hypogonadism prefer to initiate and maintain virilization with testosterone. At a time when fertility is desired, it may be induced with either pulsatile LHRH or (more commonly) with a schedule of injections of hCG and FSH.
In patients with hypergonadotropic hypogonadism, fertility is not possible.
Surgical Care: The only issue of surgical relevance is whether gonadal tissue should be removed.

As a result of the significant risk of gonadoblastoma and carcinoma, gonadal tissue should be removed in females with karyotypes containing a Y chromosome. This situation exists in a female with XY gonadal dysgenesis or in a patient with Turner syndrome who has a karyotype containing a Y chromosome (usually in 1 of 2 or more mosaic karyotypes).
Males with nonfunctioning testicular tissue should undergo orchiectomy and replacement with prostheses.
Consultations: Consultation with a reproductive endocrinologist is required for patients who would like to become fertile. Administration of pulsatile LHRH in adolescents before fertility is desired carries no benefit.

Treatment of patients with hypergonadotropic hypogonadism involves replacement of sex steroids in both males and females.

For treatment of patients with hypogonadotropic hypogonadism, the usual approach is replacement of sex steroids that initiate development and maintain secondary sex characteristics.

Sex steroid replacement does not result in increased testicular size in males or fertility in either males or females. Gonadotropin or GnRH replacement is offered to the patient when fertility is desired.

Many oral contraceptives can provide estrogen and progesterone in a combination that will meet the replacement needs of the patient. Selection of a specific oral contraceptive agent needs to be individualized. All of the contraindications, cautions, and drug interactions for estrogens and progesterones apply, as listed in the tables below.

What is the treatment?
Several testosterone delivery methods exist. These include testosterone injections, patches, and topical ointments.

Testosterone injections are considered both safe and effective. Injections are given approximately every 2 weeks. It is common to experience fluctuations in symptom relief between doses.

Another alternative is testosterone patches. The testosterone may be mixed with the adhesive with a new patch applied daily to a different site; this system leaves a sticky residue but causes little skin irritation. A different patch uses testosterone in a reservoir system applied to skin; this system adheres more tightly to the skin but may cause more skin irritation.

Also available is a topical 1% testosterone gel. It is applied once daily to clean, dry skin of the shoulders, upper arms, or abdomen. The hands should be washed and the application site allowed to dry for 3-5 minutes before dressing. A shirt must be worn during contact with women or children to prevent transfer of testosterone to them.

Side effects of any testosterone therapy may include acne, gynecomastia, aggravation of sleep apnea, and reduced HDL levels.

Hormonal preparations are available for men and women. Estrogen comes as a patch or pills. Testosterone can be given as a patch or via injection.

For women who have not had their uterus removed, combination treatment with estrogen and progesterone is often recommended to decrease the chances of developing endometrial cancer. In addition, low dose testosterone can be added for hypogonadal women with a low sex drive.

If there is a correctible cause of hypogonadism (e.g., a pituitary tumor), medication may be given (particularly for prolactinoma) or surgery and/or radiation therapy may be required. Injections or oral medication can be used to stimulate ovulation. Injections of pituitary hormones may be needed for men with hypogonadism to produce sperm. Therapy may also target nutritional, infectious, or other causes of the problem.


Replacement of missing body chemicals is much easier than suppressing excesses. Estrogen replacement is recommended for nearly all women after menopause for its many beneficial effects. Estrogen can be taken by mouth, injection, or skin patch. It is strongly recommended that the other female hormone, progesterone, be taken as well, because it prevents overgrowth of uterine lining and uterine cancer. Testosterone replacement is available for males who are deficient.

Treatment depends on the source of the problem.

-intramuscular (IM) testosterone or slow-release testosterone skin patch
-estrogen and progesterone pills
-GnRH injections

What treatment is available for hypogonadism ?

Testosterone can be replaced in one of 4 ways. There are advantages and disadvantages of each.

1.Primoteston muscular injections every 3-4 weeks.. Injections may be uncomfortable, and patients may experience a tail-off in the effect of testosterone just prior to the nxt injection

2.Testosterone skin patches. Skin irritation may be a problem, and a new area of non-hairy skin is required every day in a 7 day cycle. Some patients find them obtrusive.
Testosterone concentrations in the blood however are more stable

3.Subcutaneous implants. Requires implants to be tunnelled under the skin after local anaesthetic. Local sepsis and implants falling out can be a problem. Usually they are replaced every 6 months.

4.Restandol tablets - regrettably not sufficient for many sexually active men.
http://www.dundee.ac.uk/medther/tayendoweb/images/hypogonadism.htm#What%20treatment  (+ info)

what is the age in which HYPOGONADISM in males should be taken seriously and consult a physician?

if a boy got the symptoms of hypogonadism and his age is 18 years, he should consult doctor immediately? or still wait for the secondary sexual characters to grow?

If at 18 he still does not exhibit the secondary sexual signs, then a trip to the doctor is MOST DEFINITELY warranted because something has already gone seriously wrong! Even if he is fully developed, any time that he begins to show signs of hypogonadism, and there is NO steroid use involved, then he definitely should see a doctor.  (+ info)

How long does it take to feel the effects of Testosterone Replacement Therapy for hypogonadism?

I had blood tests done recently to find out what was wrong with me. Thought it was my thyroid but turns out it's hypogonadism. I just started using 50 mg testim gel daily and I wanted to know how long it takes to start feeling real effects from it. Also any additional info would be greatly appreciated. Personal experience ect. It's secondary hypogonadism btw luckily the family jewels are good to go

On the average it takes about three months to see a really big difference. A sense of well-being may be what you notice first.
You need to have careful monitoring to ensure that the dose you are on is right for you.
Keep in mind that doctors are very conservative by nature and are apt not to start you off on the dose of testosterone that you require.Needless to say, this is one of the factors that may delay the result you want. Good luck!  (+ info)

What is the youngest age a male could know that he has hypogonadism?

congenital, it can be seen at birth. upon develepmental stages it can be diagnosed later and up to age two. any concern of lack of dropping of testicles would be observed over period of time durring the first year.

Deficiency of sex hormones can result in defective primary or secondary sexual development, or withdrawal effects (e.g., premature menopause) in adults.

There are many possible types of hypogonadism and several ways to categorize them.

[edit] by Congenital vs. acquired
An example of congenital hypogonadism (present at birth) is Turner syndrome.
An example of acquired hypogonadism (develops in childhood or adult life) is castration.

[edit] by Hormones vs. fertility
Hypogonadism can involve just hormone production or just fertility, but most commonly involves both.

Examples of hypogonadism that affect hormone production more than fertility are hypopituitarism and Kallmann syndrome; in both cases, fertility is reduced until hormones are replaced but can be achieved solely with hormone replacement.
Examples of hypogonadism that affect fertility more than hormone production are Klinefelter syndrome and Kartagener syndrome.

[edit] by Affected system
Hypogonadism is also categorized by endocrinologists by the level of the reproductive system that is defective.

Hypogonadism resulting from defects of the gonads is traditionally referred to as primary hypogonadism. Examples include Klinefelter syndrome and Turner syndrome.
Hypogonadism resulting from hypothalamic or pituitary defects are termed secondary hypogonadism or central hypogonadism (referring to the central nervous system).
Examples of Hypothalamic defects include Kallmann syndrome.
Examples of Pituitary defects include hypopituitarism.
An example of a hypogonadism resulting from hormone response is androgen insensitivity syndrome.

Low Testosterone can be identified through a simple blood test performed by a physician. Normal testosterone levels range from 298 - 1098 ng/dl.

go get tested =)  (+ info)

Can or Does your penis shrink if you have HYPOGONADISM?

I have low testosterone and I think my penis is shrinking? Is this treatable and reversable?

I really doubt it. Your nuts might shrink. If you want to treat just put a plank under your dick and tie your dick to the tip so it stays stretched out...idk what else to do it.  (+ info)

51 year old man with hypogonadism and hyperthyroidism?

I have an appointment with endocrinology
But what do those 2 things together indicate?

possibly a pituitary gland problem, the endocrinologist will be able to diagnose and explain any problems you have, you will defiantly be on a HRT regimen.  (+ info)

My husband has hypogonadism. Which medicine is best to get his testerone level up?

He is 44, not overweight and does not smoke. He is on 5 mg. of Testim and still his blood level of testerone is 400. The doctor says that is normal, but we don't think that is normal for a man of his age and he has trouble functioning. He has been on testerone replacement for 5 years.
He has tried exercising regularily and lifting weights and it has not helped.
My husband only weighs 155 lbs. and the Testim is a creme similar to Androge.

Please understand some facts:

Mens' dysfunction is not absolutely related to serum testosterone levels PER SE.

what matters is not simply testosterone levels - but FREE testosterone levels. But as men age, after 35, the body starts to produce large amounts of SEX-HORMONE BINDING GLOBULIN which binds & inactivates the testosterone he produces from his gonads. the older he gets, the more SHBG he produces. this substance, also grabs & inactivates any exogenous testosterone he receives from injections or whatever. So only a fraction of hormones he takes will be effective at all.

Plus, as the man ages, the cellular receptors which react and respond to free testosterone begins to lose their sensitivity to the hormone, even when serum levels are adequate. this also happens with thyroid & other hormonal cellular receptors.


Also , as men age, the levels of their own electricity in the nervous system decline - & the sexual response depends entirely on an adequate level of electrical impulses for erection, orgasm & functioning.

so don't expect miracles from testosterone. He's typical for his age. Also , arteriosclerosis impedes blood flow into the penile artery & this impairs erection, also.


Remember all of this & leave your husband alone. he's going through his andropause - change of life. And that's that.  (+ info)

how does a male with hypogonadism use hcg if they want to increase their testosterone levels?

He follows the instructions his physician gives to him if they feel he needs any treatment. Is the hypogonadism diagnosed or just an opinion? Is it primary or secondary? Has he tried androgen replacement therapy? This usually is the preferred method.

HCG may not help the problem he is experiencing.

I see you have several questions posted and you are not getting very many good answers. Too many jerks on YA to get real info, and many others that just copy and paste from some other website. If you have been diagnosed, your physician can give you a referral to an endocrinologist if they feel that is appropriate. They may want to do some testing first to see what is causing the hypogonadism. They may choose to send you to a urologist or possibly a neurosurgeon.

This is a good website to explain things a little better.


It has a great flow-chart to show how a diagnosis needs to be made, and can explain how it may take some time to get to the cause.

You don't want to jump to HCG or HGH without the proper evaluations.

Again, you need to know if it is primary (testes are not responding to FSH and LH) or secondary which may be a pituitary problem. This would determine the type of doctor you should see.

If you are not getting competent answers from your doctor, see another.
Don't buy into the over the counter junk pills that say they can increase your HGH. They are not HGH, they just try to stimulate something that possibly shouldn't be stimulated. They could have the opposite effect on you, from what you are seeking.

I do not live anywhere near NYC, so have no idea who you could see, but again your primary care physician should be able to give you a referral, and why they are going the route they choose.

I wish you luck in your search and good health.  (+ info)

besides genetic problems and harm to the testicles would other things could cause hypogonadism?

There are many causes. eMedicine has 24 links to articles about this. : (  (+ info)

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