FAQ - Methemoglobinemia
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What do argyria and methemoglobinemia have in common?


How is the main supposed visible symptom in each really brought about?
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type your question in yahoo and go to where it says
emedicine:argyria something
and to
emedicine:methemoglobinemia somethig some  (+ info)

How frequently does methemoglobinemia happens?


You can look into this website to know more about the disease and or the frequency that it happens:

http://www.answers.com/topic/methemoglobinemia

Good luck to youl.  (+ info)

Methemoglobinemia, aka "Blue People"?


Methemoglobinemia is a condition where the skin literally is blue, but it can be cured through daily tablets of methylene blue (ironic, I know).

My question is, has anybody been able to find a true photo of a person with methemoglobinemia? Like of the Fugates of Troublesome Creek? The only picture I can find doesn't even look like a real picture- it looks more like a drawing.
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Here is one;
http://www.healthsystem.virginia.edu/internet/medtox/cct/consult.cfm  (+ info)

Genetic disorder methemoglobinemia (blue person disease)?


Is methemoglobinemia a chromosomal disorder or a gene disorder? i can't tell....any doctors or biology experts out there? lol
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It's caused by a recessive gene, but it manifests itself in a chromosomal error. So the answer is, yes....it's a chromosomal and genetic disorder.  (+ info)

which is worse - 50% carboxyhemoglobinemia or 50% methemoglobinemia?


I hope this is not a personal question.

Neither is good. Carboxyhemoglobin is carbon monoxide that is attatched to the hemoglobin.

50% is severe poisoning that can cause death. Remember that carbon monoxide binds to hemoglobin 200% more than oxygen. You can get CO poisoning from house fires, furnaces, and car fumes to name a few.

Methemo is is when you have red blood cells and the oxygen can't bibind to it. At 50% a coma, seizures and other symptoms can occur. 70% is the fatal range.

All in all, both are extremely bad.  (+ info)

If Methemoglobinemia has been ruled out ... what next?


If you have blood gas results (Co-Oximetry), that are the following:

O2Hb 66%
MetHb 20%
COHb 1%
HHb 13%

You were given methylene blue via IV x 2 occassions, and the MetHb is not affected, what would be the next step in evaluating this patient?
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I think your logical step is to suspect Sulfhemoglobinemia (SHb) ... which would probably have to be sent off to some large diagnostic lab .. you see ... SHb has the same absorption spectra as MetHb ... approx. 626 nm. Thus automated blood gas analyzers with spectrophotometers are unable to accurately differentiate between the two species ... I know some labs that will add cyanide to the assay ... where the MetHb turns to cyanomethemoglobin and changes absorption characteristics ... and the SHb is an irreversible hemichrome, and unaffected by cyanide, thus when the measurements are made ... the measured MetHb ... actually represents the SHb ...

After you have established this rare diagnosis ... generally ... with SHb .. the oxyhemoglobin curve shifts to the right ... which will actually ameliorate the effects of reduced oxygen binding capacity and enhances oxygen delivery to the tissues ..

How do you get rid of it? Actually, they usually allow the natural churn over rate of RBC's (57 to 60 days ... I forget) ... unless the SHb is huge ... then I guess you have to consider a transfusion (never seen that done)  (+ info)

how to avoid nitrate in our water?


my son turned blue. looked it up on the net and it stated that nitrate in the water supply can cause "blue baby syndrome" also known as Methemoglobinemia. What is the best way to avoid nitrate and where can you go to get your water tested for nitrate?
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The best way I know of, or at least the way I filter my water is with a water distiller. It literally boils the water and then condenses the steam into what I would consider the purest water I've ever had in my entire life.They are more expensive than a Brita filter, but definitely an investment worth making if you clean it regularly and maintain it. Not to mention it is a one-time investment where as in a Brita filter you have to continually buy filters/cartridges that don't filter the water as effectively as a distiller.

I own both, use both, and love both; but would definitely recommend the distiller for your specific question.

I hope this answer helped you.  (+ info)

is benzocaine (anaesthetic used in climax control condoms) dangerous?


im just wondering cuz i got some and they work well, but after looking up benzocaine i found out it can cause Methemoglobinemia (which basically suffocates the cells). Is the ammount found in those condoms (5%) enough to cause Methemoglobinemia? and is it safe in general?
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No...not using condoms are dangerous...all brands got sth that may cause a histamines on ur skin , but don't worry  (+ info)

took my eight month old son to e.r cause he turned blue. Dr said he had mottling. But he shows no signs of?


took him to the family peditrician and got blood work done. Dr said that it isnt mottling that it may be linked to food,medication or water supply. He said there may be a posibilty that it may be Methemoglobinemia, and i was wondering does fluconazole or nystatin have anything to do with it, due to the fact that my son has been on and off these med's for a couple of months??? please help.
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Yes, fluconazole and nystatin can both cause methemoglobinemia; but this is not common. Also, if the metHb was that high, then your son would have been admitted for treatment.

MetHb can also be caused by nitrates from drinking water, particularly in infants; and it can also be genetic, but it would more likely have surfaced sooner in this case.

Was the blue hue something that came on suddenly, or was it gradual? Likewise, did it just disappear, or go away more slowly? The former of both of these questions leads more toward cyanosis, the latter more toward metHb.

If it came on suddenly, it should be viewed as an apparent life-threatening experience, or "ATLE" in pediatric slang. If the doctors are currently being passive and dismissive, then please keep a journal and a camera nearby. If it happens again, document how quickly it came on, how deeply blue he became, his mental/physical activity level, etc; and get some photographs.

It is easier to dismiss a parent when there is no evidence to back up that parents claim; but if you come with documents and pictures, they would be absolutely remiss if they failed to investigate.

Cheers!  (+ info)

Is it safe for a pregnant woman to drink infant formula?


I would think not....


Aluminum

<5-45 ug/l in breast milk
557-2,346 ug/l in soy formula
Aluminum interferes with cellular metabolic processes and information transfer from DNA

Silicon

55.45ng/ml in milk of mothers with silicone implants
51.05ng/ml in milk of mothers without implants
746-13,811 ng/ml in 26 brands of formula tested for silicon
The effect of large amounts of silicon on an infant is unknown

Cadmium

Cadmium is a highly toxic metal that can cause kidney damage in high amounts. Neurotoxic effects such
as psychomotor disturbances, behavioral and cognitive disorders have been demonstrated in animal models
with low-dose exposure. Cadmium levels can be 6 times higher in soy formula compared to milk- based
formula. Cadmium is also found in cereals with the exposure of dietary cadmium from weaning diets up to
12 times higher in children fed infant formula compared to breast milk.
Genetically engineered corn and soy
Detected in Alsoy (Carnation/Nestle), Similac Neocare (Ross Labs), Isomil (Ross Labs), Prosobee (Mead
Johnson)
Transgenic ingredients pose the risk of introducing novel toxins, new allergens, and increased antibiotic
resistance to infants. The FDA does not require labeling of genetically engineered foods, so parents will
remain unaware that their baby is consuming transgenic ingredients

MSG (processed free glutamic acid and processed free aspartic acid)

These are known neurotoxins found in a number of infant formulas. Because the blood brain barrier is not
fully developed in infants, these neurotoxins are more accessible to the infant brain than the adult brain.
The highest levels of these neurotoxins were found in hypoallergenic formulas. Because no studies have
been done on the long term outcomes of infants fed on hypoallergenic formulas it is unknown if they
will exhibit more learning disabilities at school age, and/or more endocrine disorders such as obesity, and
reproductive disorders, later in life.

Phytoestrogens

Phytoestrogens are endocrine disruptors found in soy formulas. Infants fed soy formula can have circulating
phytoestrogen concentrations that are 13,000-22,000 times higher than normal levels in early life. These
bioactive compounds can create steroid hormone imbalance, compete with enzymes that metabolize steroids,
drugs and xenobiotics, and can influence gonadal function. Genistein can be carcinogenic if exposure
occurs during critical periods of differentiation. Soy formula has been linked to premature thelarche (breast
development in infants and girls under eight years of age). Phytoestrogens (isoflavones) also act on the
thyroid gland. They are well known inducers of goiter and anti-thyroid agents. They act against the thyroid
by inhibition of thyroid peroxidase. Children with autoimmune thyroid disease were three times more likely
to have been fed soy formula in infancy.
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Phthalates and Bisphenol-A

These are endocrine disrupting industrial chemicals. Phthalates are used as plasticisers and are testicular
toxins as well as estradiol imitators.
Bisphenol-A is used in the production of polycarbonate plastics and has been found in plastic baby bottles.
It can leach from the container and has been known to be estrogenic since 1938. Bisphenol-A resins are
used as lacquers to coat metal products such as food cans. With a high affinity for fatty products, it has
been shown to leach into the content of cans during the autoclaving process, including cans of milk based
infant formula.
Contaminants in water used to reconstitute concentrated and powdered formula

Lead

Lead in water used to reconstitute formula can cause elevations in blood lead levels if used from the hot
water tap or boiled. Boiling concentrates lead. There is a 6 point IQ drop for every 10ug increase in blood
lead levels.

Nitrates

Infants fed formula reconstituted with nitrate-contaminated water are at risk for potentially fatal methemoglobinemia.
Nitrates are converted to nitrites by the baby resulting in hemoglobin being converted to
methemoglobin that cannot bind molecular oxygen. This risk increases if babies under six months are also
fed baby food with high concentrations of nitrates such as green beans and bananas.

Atrazine

Atrazine is a weed killer that causes mammary and uterine cancer in rats. In the cities and towns with
the worst tap water contamination, formula-fed babies who consume reconstituted formula would receive a
lifetime dose of this chemical in the first four months of their lives.

Bacteria

Significant bacterial contamination can occur during home preparation of powdered infant formula.
Reconstituted formula stored in the refrigerator shows increasing bacterial counts over time
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makes me glad im a breastfeeder....but then again i was formula fed....i wonder how that affects my milk now...?  (+ info)

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