FAQ - Nevus of Ota
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Has anyone ever heard of Nevus of Ota?

Nevus of Ota is somekind a skin problem mainly passed through by genetics. Besides laser treatment, is there other way to treat nevus of ota? Does ordinary cosmetics that are sold in pharmacies can reduce the pigmentation? Does toner or whitening products help? What's the best way to treat nevus of ota besides laser treatment?

Bluish spot occurring on the face. First reported by Dr. M. T. Ota (of Japan) in 1939. It is not Mongolian spot. In Japanese it is known as 太田母斑. Females are nearly 5 times more likely to be affected, and it is rare among Caucasians. Nevus of Ota may not be congenital, and may appear during puberty. Q-switched laser treatment provides satisfactory treatment.  (+ info)

Nevus of OTA.. and Acne. help!!?

I'm suffering from Nevus of Ota; the pigmentation disease on my cheek, forehead and in the eyes.. My doctor suggested that Laser treatment is the only remedy for that.. Is there any other methods for curing Nevus of OTA?? Will Laser treatment cause any side effects? I'm 15 yrs old and I've a lot of Acne too. Is there any relation between Nevus Of OTA and Acne?? Please help me

There is no relation betwen nevus of OTA and acne problems..
Laser is one of therapy for nevus, other is minor operation and cauter.  (+ info)

Have you heard about a skin disease "nevus ota"?

Background: Nevus of Ota, which originally was described by Ota and Tanino in 1939, is a hamartoma of dermal melanocytes. Clinically, nevus of Ota presents as a blue or gray patch on the face, which is congenital or acquired and is within the distribution of the ophthalmic and maxillary branches of the trigeminal nerve. The nevus can be unilateral or bilateral, and, in addition to skin, it may involve the ocular and oral mucosal surfaces.

Nevus of Ito, initially described by Minor Ito in 1954, is a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.

Pathophysiology: The etiology and pathogenesis of nevi of Ota and Ito are not known. Although unconfirmed, nevus of Ota and other dermal melanocytic disorders, such as nevus of Ito, blue nevus, and mongolian spots, may represent melanocytes that have not migrated completely from the neural crest to the epidermis during the embryonic stage. The variable prevalence among different populations suggests genetic influences, although familial cases of nevus of Ota are exceedingly rare. The 2 peak ages of onset in early infancy and in early adolescence suggest that hormones are a factor in the development of this condition. The observation of dermal melanocytes in close proximity with nerve bundles in nevus of Ito suggests that the nervous system is a factor in the development of nevus of Ito, although the true pathogenesis remains unknown.

Mortality/Morbidity: Nevus of Ota can cause facial disfigurement, resulting in emotional and psychologic distress. In rare cases, melanoma, which can be life threatening, has been reported to arise from nevus of Ota. Glaucoma also has been associated with nevus of Ota.

Nevus of Ito usually does not have symptoms and causes little cosmetic concern to the patients; however, sensory changes occasionally are present in the lesion.


Nevi of Ota and Ito occur most frequently in Asian populations, with an estimated prevalence of 0.2-0.6% for nevus of Ota in Japanese persons. Nevus of Ito is less common than nevus of Ota, although true incidence is unknown.
Other ethnic groups with increased prevalence include Africans, African Americans, and East Indians.
Nevi of Ota and Ito are uncommon in whites.

Male-to-female ratio is 1:4.8 for nevus of Ota. The ratio for nevus of Ito is unknown.

The first peak of onset of nevus of Ota occurs in infancy, with as many as 50% of nevus of Ota cases present at birth. The onset for nevus of Ito is at birth or shortly after.
The second peak of onset for nevus of Ota is seen during adolescence.
Isolated cases of delayed-onset nevi of Ota that first appear in adults, including in older patients, have been reported.

CLINICAL Section 3 of 9
Author Information Introduction Clinical Differentials Workup Treatment Follow-up Miscellaneous Bibliography

History: After onset, nevus of Ota may slowly and progressively enlarge and darken in color, and its appearance usually remains stable once adulthood is reached. The color or perception of the color of nevus of Ota may fluctuate according to personal and environmental conditions, such as fatigue, menstruation, insomnia, and cloudy, cold, or hot weather conditions. Nevus of Ota can be associated with other cutaneous disorders and ocular disease. Nevus of Ito can be associated with sensory changes in the involved skin.

Benign cutaneous and leptomeningeal conditions associated with nevus of Ota
Nevus of Ito
Phakomatosis pigmentovascularis
Nevus flammeus
Sturge-Weber syndrome
Neurofibromatosis and leptomeningeal melanosis
Malignant melanoma
More than 60 cases of malignant melanoma (56 in whites, 4 in Japanese) in association with nevus of Ota have been described in the literature as follows:

Skin - 10 cases

Meninges - 12 cases

Ocular tissues - 40 cases
To date, only 1 case of malignant degeneration of nevus of Ito has been described and involved a 78-year-old white man.
Ocular abnormalities (ocular acuity normal)
Pigmentation of the sclera, cornea, retina, and optic disc
Cavernous hemangiomas of the optic disc
Elevated intraocular pressure
Glaucoma (10.3%)
Ocular melanoma

Table. Clinical and Histologic Features for Differential Diagnoses of Nevi of Ota and ItoCondition Onset Appearance Location Histology
Nevi of Ota and Ito Birth or early adolescence Blue or gray speckled coalescing macules or patches For nevus of Ota, unilateral, rarely bilateral, on forehead, temple, zygomatic, or periorbital areas; for nevus of Ito, the shoulder and upper arm areas Increased dermal melanocytes, with surrounding fibrosis and melanophages

Mongolian spot Birth Poorly demarcated large blue-to-gray patches that tend to spontaneously resolve by age 3-6 y Most frequently on lumbosacral areas, buttocks, and rarely, other areas Increased dermal melanocytes; no surrounding fibrosis

Blue nevus Congenital or acquired Blue papules or plaques Anywhere on skin Dermal nodular proliferation of heavily pigmented spindle cells

Melasma Acquired; may be associated with pregnancy and other estrogen excess stages Well-to-poorly demarcated and irregularly outlined brown-to-gray brown patches Maxillary and zygomatic areas on face No increase in dermal melanocytes; presence of melanophages

Lentigo maligna Acquired; presenting usually after fifth decade of life Brown patches, usually with pigmentary variegation Photodistribution, particularly within zygomaticomaxillary areas Atypical melanocytes in nests at dermal-epidermal junction, with pagetoid spread

Actinic lentigo Acquired; usually after fifth decade of life Well-demarcated brown papules or plaques Photodistribution, especially on face Elongation of rete ridges; basal layer hyperpigmentation; slight increase of melanocyte number along basal layer

Phytophotodermatitis Acquired; exposure to certain plants or cosmetics Gray-to-brown macules and patches Photodistribution, according to sites of contact with photosensitizer Dermal melanophages

Drug-induced hyperpigmentation Acquired; following drug exposure (eg, minocycline, amiodarone, gold) Variable according to offending drugs Variable according to specific offending drugs Variable but may involve presence of dermal melanophages; pigmentation of basal keratinocytes

Exogenous ochronosis (rare) Adulthood; following topical application of hydroquinone Irregularly shaped blue-to-gray patches or macules Areas corresponding to exposure to hydroquinone Yellow banana-shaped spindle cells in papillary dermis

Ochronosis (alkaptonuria, rare) First decade of life Blue-gray discoloration of ear cartilage, tip of nose, and sclera Symmetrical distribution over cartilage, nose, cheeks, and extensor tendons of hands, as well as flexural areas Yellow-to-brown pigmentary granules within dermal macrophages

Nevus of Ota most frequently presents as blue-to-gray speckled or mottled coalescing macules or patches affecting the forehead, temple, malar area, or periorbital skin. Nevus of Ito presents as a patch on the shoulder or upper arms with blue, gray, or brown pigmentation.
Most cases of nevus of Ota are unilateral (90%), although pigmentation is present bilaterally in 5-10%. Nevus of Ito usually is unilateral.
In addition to skin, pigmentation of nevus of Ota may involve oral mucosa and ocular structures such as the sclera, retrobulbar fat, cornea, and retina.
Clinically, nevus of Ito is similar to nevus of Ota, except that it typically presents over the shoulder girdle region.
Specific variants of nevus of Ota have been described in the literature under the names of nevus fuscoceruleus zygomaticus, plaque-type variant of blue nevus, or Hori nevus. Some clinicians consider Hori nevus to be a distinct entity that is separate from nevus of Ota. Differential features of these conditions are related to the following:
Location of patch or macules
Extent of involvement
Age of onset
Tendency to occur as familial cases
Presence of a papular component
Pathology and response to therapy appear similar for all forms of nevus of Ota. The pathology of nevus of Ito is similar to that of nevus of Ota.
Causes: The cause of nevi of Ota and Ito is unknown.  (+ info)

Nevus of Ota Treatment Costs?

Does anyone know about how much it costs to get the removal using laser?

You can easily check your minimal health care rates in internet, for example here - healthquotes.awardspace.info  (+ info)

Does anyone have a nevus of ota birthmark? If so, are you getting it treated?

My daughter is 2 she was born with one on her side. She had to get it removed, it took two sugeries. She is doing great now though. It did not even bother her though.  (+ info)

hi i just wanna see if anybody can help me with my problem i j=have nevus of ota under my eye im so frustrated?

You should be periodically examined by an eye-care specialist and a neurologist.
Most patients with the Nevus of Ota have no subsequent related problems.
Treatment of a naevus of Ota is usually cosmetic camouflage to cover the disfiguring markings. Laser treatment and intense pulsed light (IPL) work by destroying the dermal melanocytes. Unfortunately recurrence is common after laser clearance, sometimes resulting in a darker hue.  (+ info)

How to remove nevus with a simple way by myself at home?

How to remove the nevus on my nose? Don't tell me go to do surgery or use laser...I want ways that I can do at home by myself. Somebody suggests me to lightly rub the nevus with fresh lemon juice by using a Q-tip. I've tried that, it seems to work a very very very little bit but please give me a better way because it hurts my nose and takes a long time and I'm still suspecting whether it works or not.

Sorry, you need to see a dermatologist for nevus removal in office.  (+ info)

Why would doctors excise an atipical nevus?

I had a mole removed (shaved) and it came back as an atypical nevus, I am going to go back to have the rest taken out, but if it's not cancer why do they need to take the rest out?

Because of the word "atypical". An atypical nevus has the possibility of degenerating into a melanoma, as opposed to a regular nevus. So, to be on the safe side, it's better to get rid of a potentially serious condition, easily, than to wait until (if ever) it does turn into a malignancy that can cause death. And, of course, there is the legal side of this too: should it turn into a melanoma, and the doctor had not taken it off, then he'd probably be looking at a law suit for not having acted sooner and preventing a death.  (+ info)

Does anyone know anything about sebaceous nevus?

I have read that sebaceous nevus can be linked with neurological disorders. Would a child be born with these disorders, or could the child develop normally as an infant, then the disorder develop later?

Nevus sebaceus is usually noted as a solitary lesion at birth or in early childhood, whereas the characteristic features may not develop until puberty.

Here's an article on the condition:

http://www.dermnetnz.org/lesions/sebaceous-naevus.html  (+ info)

any other babies have a Linear Sebaceous Nevus?

My 12 week old son has just been diagnosed with a Linear Sebaceous Nevus, i was hoping for any advice or stories from parents who have experienced this with their children?
In common terms, Nevus means a birthmark or mole. They are generally benign but few have malignant (cancerous) potential. It depends on type, location, size and other morphological features of the mole.
Sebaceous nevus is a very rare type of epidermal nevus disease. It may be associated with other birth abnormalities.

sorry really dont mean to be rude..im just wondering what linear sebaceous nevus is? ive never heard of it...  (+ info)

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