FAQ - Oligodendroglioma
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the drug lodamina is compatible against brain cáncer or oligodendroglioma anaplasico grade III??


please let me know , because , my uncle have this cancer and she is very sad Thanks!
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What is the chemical name of the drug in English? Sorry but I do not read Italian and all the articles I found about this drug are in Italian.

good luck to your uncle  (+ info)

is temozolomide good for remeding of oligodendroglioma grade 2?


i'm 28 years old,4 monnths ago ,i had surgical operation for my oligodendroglioma grade 2,then i performed radioterapy,but this time doctor said me:you have to do chemtropy or use temozolomide,i don't know which one is better?
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Temozolomide (Temodar) is chemotherapy. My son took it in combination with Irinotecan for abdominal sarcoma. After he was on this protocol for a month the lesions in his lungs disappeared. He continued on this protocol for 8 months with no serious side effects. Towards the end of treatment he had diarrea that was controlled using Immodium.

All in all it was a good protocol for him. I am not sure about the oligodendroglioma, although I understand that Temozolomide is able to pass the blood brain barrier so is often used to treat brain tumors.

There are studies indicating there may be benefit for patients with your disease:
http://virtualtrials.com/news3.cfm?item=3713

"Temozolomide treatment for newly diagnosed anaplastic oligodendrogliomas: a clinical efficacy trial.

Taliansky-Aronov A, Bokstein F, Lavon I, Siegal T.

Leslie and Michael Gaffin Center for Neuro-Oncology, Hadassah Hebrew University Hospital, Ein-Kerem, Jerusalem, Israel.

PURPOSE: Chemotherapy with alkylating agents is of proven efficacy in recurrent anaplastic oligodendroglioma (AO) with reported response rates ranging between 50% and 70%. The response of newly diagnosed AO to initial treatment with temozolomide (TMZ) has not yet been reported. This study evaluated the response and time to tumor progression of newly diagnosed AO initially treated with TMZ. PATIENTS AND METHODS: Twenty patients with a median age of 47 (range: 26-65) received a median of 14 (range: 3-24) cycles of TMZ as their first modality of therapy following diagnosis of AO. Treatment was given every 28 days for 5 days at a starting dose of 200 mg/m2/d and was continued for 24 cycles unless toxicity or tumor progression required withdrawal of TMZ. MRI evaluations were repeated every 8 weeks and scales of Karnofsky performance status (KPS) and of neurological function were used to assess clinical response. RESULTS: Clinical improvement was observed in 60% of the patients with statistically significant gain measured by KPS and the neurologic function scales. The objective response rate was 75%, and median time to tumor progression was 24 months. Maximal objective response was reached within a median of 6 months (range: 3-12). Tumors with 1p loss had longer progression free survival compared to tumors without deletions (PFS at 24 months: 1p LOH = 100%, 1p intact = 20%; P = 0.057). TMZ was well tolerated with only two events of grade 3/4 hematological toxicity. CONCLUSIONS: Newly diagnosed AO demonstrates a high rate of response to initial therapy with TMZ, similar to the response reported for PCV combination therapy. Further studies are needed to determine the optimal duration of treatment and whether radiotherapy should immediately follow chemotherapy."

Good luck with your choice.  (+ info)

is oligodendroglioma a maliganent tumor?


it is a form of brain tumor that I was just diagnosed with and had surgery to have it removed
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Oligodendroglioma

Definition

Oligodendrogliomas are a rare form of brain tumors. The brain is made up of many supporting cells that are called glial cells. Any tumor of these glial cells is called a glioma. Oligodendrogliomas are tumors that arise from a type of glial cell called oligodendrocytes. These cells are the specialized cells of the brain that produce the fatty covering of nerve cells (myelin).

Description

Oligodendrogliomas can grow in different parts of the brain, but they are most commonly found in the frontal or temporal lobes of the cerebrum. The frontal lobes are responsible for cognitive thought processes (knowing, thinking, learning, and judging). The temporal lobes are responsible for coordination, speech, hearing, memory, and awareness of time.

There are two types of oligodendroglioma: the well-differentiated tumor, which grows relatively slowly and in a defined shape; and, the anaplastic oligodendroglioma, which grows much more rapidly and does not have a well-defined shape. Anaplastic oligodendrogliomas are much less common than well-differentiated oligodendrogliomas.

More common than either form of pure oligodendroglioma is the mixed glioma, or oligoastrocytoma. These mixed gliomas are a mixture of oligodendroglioma and astrocytoma. An astrocytoma is a tumor that arises from the astrocytes, specialized cells in the brain that regulate the chemical environment of the brain and help to form the blood-brain barrier.

Oligodendrogliomas and mixed gliomas account for approximately 4 to 5% of all primary brain tumors and 10% of all gliomas. A primary brain tumor is a tumor that begins in the brain, as opposed to a secondary (or metastatic) brain tumor, which originates in another organ and spreads (metastasizes) to the brain.

Demographics

Oligodendromas occur in approximately nine in every one million people. Oligodendrogliomas can occur in people of any age, but most occur in middle-aged adults.

Oligodendrogliomas occur with equal frequency in members of all races and ethnic groups. There does not appear to be any relation of oligodendrogliomas to any geographic region. For unknown reasons, men are affected by oligodendrogliomas in higher numbers than women.

Causes and symptoms

The cause, or causes, of oligodendrogliomas are not known; however, most people with these types of tumors have some type of genetic mutation on chromosome 1, chromosome 19, or on both chromosomes 1 and 19. In early 2001, investigations were ongoing in an attempt to determine if these genetic factors, or other factors, cause oligodendrogliomas. Oligodendrogliomas are not contagious.

The symptoms of oligodenrogliomas are the result of increased pressure in the fluid within the skull (intracranial hypertension). These symptoms include:

nausea
vomiting
irritability
headache
vision disturbances
enlargement of the head
seizures
Oligodendrogliomas may also be accompanied by a weakness or paralysis on the side of the body opposite to the side of the brain where the tumor is located. When the tumor is located in a frontal lobe, the patient may experience gradual changes in mood and personality. When it is located in a temporal lobe, the patient may experience difficulty with speech, hearing, coordination, and memory.

Diagnosis

The diagnosis of oligodendrogliomas begins in the doctor's office with a basic neurological examination. This examination involves:

testing eye reflexes, eye movement, and pupil reactions
testing hearing with a tuning fork or ticking watch
reflex tests with a rubber hammer
balance and coordination tests
pin-prick and cotton ball tests for sense of touch
sense of smell tests with various odors
facial muscle tests (e.g., smiling, frowning, etc.)
tongue movement and gag reflex tests
head movement tests
mental status tests (e.g., asking what year it is, who the President is, etc.)
abstract thinking tests (e.g., asking for the meaning of a common saying, such as "every cloud has a silver lining.")
memory tests (e.g., asking to have a list of objects repeated, asking for details of what a patient ate for dinner last night, etc.)
If the doctor suspects a brain tumor may be present, further diagnostic tests will be ordered. These tests are performed by a neurological specialist. Imaging tests that may be ordered include computed tomography (CT)and magnetic resonance imaging (MRI).Other tests may include a spinal tap, to examine the cerebrospinal fluid, and an electroencephalogram (EEG), which measures the electrical activity of the brain.

Treatment team

Treatment of any primary brain tumor, including oligodendrogliomas, is different from treating tumors in other parts of the body. Brain surgery requires much more precision than most other surgeries. Also, many medicinal drugs cannot cross the blood-brain barrier. Therefore, the therapies that are used to treat oligodendrogliomas, and the side effects of these therapies, are quite complex.

The most up-to-date treatment opportunities are available from experienced, multi-disciplinary medical professional teams made up of doctors, nurses, and technologists who specialize in cancer (oncology), neurology, medical imaging, drug or radiation therapy, and anesthesiology.

Clinical staging, treatments, and prognosis

Oligodendrogliomas and other primary brain tumors are diagnosed, or staged, in grades of severity from I to IV. Grade I tumors have cells that are not malignant and are nearly normal in appearance. Grade II tumors have cells that appear to be slightly abnormal. Grade III tumors have cells that are malignant and clearly abnormal. Grade IV, the most severe type of brain tumors, contain fast-spreadingand abnormal cells. Well-defined oligodendrogliomas are generally stage I or stage II tumors. Anaplastic oligodenrogliomas are generally stage III or stage IV tumors.

The standard treatment for all grades of oligodendrogliomas is surgery to remove the tumor completely. This surgery is generally aided by an image guidance system that allows the surgeon to determine the most efficient route to location of the tumor. Approximately half of oligodendroglioma patients gain relief of the increased intracranial pressure after complete removal of their tumors. The other half require a spinal fluid shunt to allow drainage of the excess fluid.

In some instances of oligodendroglioma, the tumor is inoperable or cannot be completely removed. Patients with inoperable oligodendrogliomas are generally treated with radiation therapies. Oligodendrogliomas are among the only brain tumors that can be successfully treated with a type of chemotherapy called PCV (Procarbazine, CCNU or lomustine, and Vincristine). Chemotherapy is usually used only in cases of recurrent anaplastic oligodendrogliomas.  (+ info)

oligodendroglioma tumour?


It's a type of brain tumor. You can find more information about this tumor at CancerBackup:

Oligodendroglioma
http://www.cancerbackup.org.uk/Cancertype/Brain/Typesofbraintumour/Oligodendroglioma

NCI: Adult Treatment for Oligodendroglioma
http://www.cancer.gov/cancertopics/pdq/treatment/adultbrain/HealthProfessional/page10  (+ info)

can i thake an expired medicine?


my brother-in-law was diagnosed brain tumor. (oligodendroglioma) he is in the state of chemotherapy he suppose to take the medicine temodal (temodar) this coming month of april but the medicine has hust expired this 24 of this month of march 2007. then my question is CAN HE STILL TAKE THE MEDICINE EVEN IT IS EXPIRED?
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Pharmaceutically speaking, the drug potency is 90% at the date of expiration, it will still work on most of the drug but you should also take into consideration that the drug to be taken is a life saving drug..  (+ info)

Please help, my dad has a brain tumor?


He has Oligodendroglioma, its a rare form of brain tumors occurs to 9 out of every 1million people. He has had it for 10 years now and has had 2 brain surgerys One being this summer at the cancer hospital (the best in the world) M.D Anderson in Houston. Now it is growing back and he has to take chemo. My moms friend who is a cancer scientist said the time frame is he will be in less then a year..
I need help. Im 15 and i dont know how to deal with this, ive been in denial..i dont talk about it. Should i tell him to go back to M.D anderson again? My mom asked is he wanted to andHe doesnt want to because he said the philadelphia doctor is fine plus he doesnt wanna get on a plane again, but if i ask him im sure he will do it.
basically i just need to know what can i do to help him
and what should i do and is there any hope?
also..is it hereditary
Thank you michelle, your answer made me cry.
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I'm so sorry to hear about you dad's tumor. I really feel bad for you and your family. I'm actually wiping away some tears.
I was in your shoes about 2 years ago. My mom was diagnosed with stage 4 inflammatory breast cancer. She was a mess. The cancer spread to her spine, lungs, and liver. The doctors gave her a year at the most. Our hospital in Danville, Pa had no hope. We took her to Fox Chase cancer hospital in Philly for a 2nd opinion. They gave her hope and worked with the hospital back home to do treatments. She beat the cancer and is doing great.
I would encourage you to talk to your dad about going back to the hospital in Texas. It's very important to keep fighting and to stay positive. He also needs to be comfortable with his doctors.
I know what it is like to see a parent go through such a horrible thing. I was away at college when I got the news. I was over 600 miles away from home. Mom wanted me to stay in college and graduate the following May. It was the worst thing I ever experienced. I was like you. I didn't know how to handle the situation. I was in the denial too. I walked around and felt like I was in a bad dream. I felt guilty for not being at home to help her when she was going through chemo.
I had a big outpouring of support from my professors, classmates, and friends. They were a big help to me. I had a professor who was a former church minister. He offered his counseling services to me. I took him up on the offer. It was what helped me pull through this hard time.
Please, if your feeling bad, go find a pastor or religious leader, a school counselor, or even a family friend to talk to. They can be a source of encouragement and comfort to you.
I am giving you a link to an organization that may be able to give you some help. There is always hope! I will say a prayer for your dad and your family tonight. God bless you!  (+ info)

Motherlaw wants to die because of cancer?


My mother in law "Rosa" has been diagnosed with cancer. She had a tumor removed last week. It has taken us over a year to get her in the hospital. She thought she had Alzheimer. So she was afraid to go to the hospital even though she had headaches for over a month and couldn't read anymore. But she really had a brain tumor an Oligodendroglioma . THE SAME BRAIN TUMOR I WAS DIAGNOSED WITH LAST APRIL. She was so bad she couldn't remember what state she lived in or the president yet her husband would let her drive.
Here's the problem before the surgery she had to take steroids to shrink the tumor. She even refused to take the steroids in the hospital we said the only way they would let her come home is if she was good and took her medication. To my husband she kept telling him she was going to die and it was her time everyday he visited her. She did not act this way toward her husband or any of the other children she is in her 60's. Surgery went well. They took out the tumor. 10 days ago.

Okay yesterday they rushed her to the hospital because she said she felt numb. The doctors took X-rays, MRI she was fine. She started with my husband again for several hours saying she was going to close her eyes and go to sleep and die. This time she did say it in front of another daughter. She also said her arms and legs were numb. But when the doctors asked her to move them she moved them fine. I'm assuming she is not all there because of the surgery. My husband's oldest sister and his father talked to the surgeon and they want to do chemo and radiation on her. How are we going to get her to do these things if she keep saying she is just to die. She is lucky to have her tumor taken out. I still have mine in my head and I did chemo and proton radiation and nothing happened. So I guess I am a little annoyed she is giving up. Plus My husband is so upset at seeing his mom giving up like this. Any suggestions on what to do about her? Do just let her give up?
She has always said since I have know her if she was to get cancer she would never take medication. So this is a typical behavior of her.
The tumor was in the front left lobe
I didn't have my tumor out because when I had my biopsy it caused my right entire leg to be paralized for a week and I had to do physical therapy and seizures afterward. They would not operate. I am now going to another hospital for a second opinion
I don't feel like i can deal with her or her husband at all they do not understand any of the information they are given. My husband or his sister has to go to the hospital for most of the appointment. His parents are stuck in the 70s and do not understand most medical information. So It's really hard to deal with both of them. Especially When the husband keep telling Rosa the wrong information.
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For patients with pure low-grade oligodendroglioma, median survival is approximately 10 years; for patients with mixed oligoastrocytoma, approximately eight years. The average age at diagnosis is 35 years. Patients typically present with seizures. See the average survival time? That means many people live longer also. Has this been explained to her? See the average mixed tumor survival length? That's the tumor I had and I'm much younger than she is. Is she missing the 1p/19q gene in the tumor? If she is, her outlook is much better, with treatment. Why have you not had surgery yet? If it's in a bad area, you should ask about gamma knife surgery. That's my next option if my tumor regrows.



That part of the brain is responsible for personality, attention, and several other cognitive functions. Could explain her attitude.
I chose not to do a biopsy. Told dr to get it out of my head. We'd worry about what it was later. Def get a 2nd opinion. If it's in an operable area, I would get it out before it grows. Good luck to both of you.  (+ info)

Brain Tumor found during coincidental MRI, should I read between the lines?


Had an MRI to establish a baseline done for something unrelated and this is what was provided to me:
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Technique: T1, T2, and FLAIR isotropic sagittal slices were aquired without contrast and examined using multi-plane reformatting in axial, sagittal, and coronal planes.
Findings: A 2cm mass demonstrating mixed signal intensity on T1, T2, and FLAIR sequences is seen with respect to the left anterior insular grey matter. The lesion appears cortically based and demonstrates several marked hypointense regions that may represent calcifications. Further evaluation is limited by lack of available intravenous contrast as dictated by the employed research study imaging protocols. Differential for these findings include both benign and malignant neoplasms, such as oligodendroglioma, PXA, DNET, or ganglioglioma. Given that the sequences included in the current MRI examination were optimized for detection of tramatic brain injury, refferal to a Neurosurgeon and/ or Neurologist,along with aquisition of a follow-up contrast-enhanced clinical MRI for further evaluation is recommended. No evidence of hydrocephalus. No evidence of midline shift. Intracranial flow voids appear normal.

So Should I be reading between the lines even though I have not yet had the contrast test done yet?
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  (+ info)

Has anyone gone to pain management for Brain tumors?


I have brain Cancer (tumor oligodendroglioma) and I have very bad headaches. I've had a headache for the last 5 months. I was diagnosed in March 2008 with my cancer I had a seizure. That's when they found my tumor. I just started having the headaches so they are sending me to pain management. I was wondering what they do and if it has helped anyone. They don't want to take out my tumor unless it starts causing "major problems" because it will paralyze me because of where it's located.
My neurosurgeon is the one sending me to the pain management
I get MRI's every 3-6 months to check for changes in the size of my tumor. I had proton radiation and chemo done in 2008.
I also did the steriods too. I had headaches right after I stopped proton radiation. That was in 2008. these headaches started in the end of 2009. I have had 2 MRI's since then and there has been no changes in my tumor.
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I don't have a brain tumour but I know someone who also gets bad headaches. He is prescribed oxygen for it. I'm not sure how it helps, but it does.

I don't have a brain tumour, but I do have another kind of cancer, and a pain team comes to visit me. They're really nice. They ask what the pain is like (eg sharp, dull etc), how bad it is (eg 1-10), and other things like what time of the day it's the worst (for me it's the morning), and they work out a plan for you. So I have slow release pain control all the time, and something else that works for shorter breakthrough pain. They check up on me every now and then as things progress.

I hope you start feeling better soon.  (+ info)


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