FAQ - Oral Submucous Fibrosis
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What is treatment for Oral SubMucous Fibrosis?

Besides stopping gutka consumption

OSF caused by consumption of pan or gutka, can be cured by using anti oxident drugs, along with stopping of causative agents.anti oxidents availabla in markets are `ala 100` and `softace` these can be consumed twice daily, for a month or more..  (+ info)

Hi,Can anyone tell me about possible treatment options of oral submucous fibrosis...?

Specially interferon gamma and steroids.....
I hve read an artical saying interferon gamma can reverse it.....

Drug Name
Dexamethasone (Decadron) -- For various inflammatory diseases. Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reducing capillary permeability.
Adult Dose 4 mg IV/IM (suggested in studies)
Pediatric Dose Dose in children should be based on severity of disease and response rather than adherence to dose indicated by age, body weight, or BSA
Contraindications Documented hypersensitivity; active bacterial or fungal infection
Interactions Effects decrease with coadministration of barbiturates, phenytoin, and rifampin; decreases effect of salicylates and vaccines used for immunization
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Increases risk of multiple complications, including severe infections; monitor adrenal insufficiency when tapering drug; abrupt discontinuation of glucocorticoids may cause adrenal crisis; hyperglycemia, edema, osteonecrosis, myopathy, peptic ulcer disease, hypokalemia, osteoporosis, euphoria, psychosis, myasthenia gravis, growth suppression, and infections are possible complications; caution with individuals exposed to viral illnesses, such as chickenpox or measles
Drug Name
Triamcinolone acetonide (Aristocort, Kenaject) -- Suppresses immune system by reducing activity and volume of lymphatic system. Treats inflammatory mucosal lesions that are responsive to steroids. Decreases inflammation by suppressing the migration of polymorphonuclear leukocytes and by reversing capillary permeability.
Adult Dose Oral inflammatory or ulcerative lesions (dental paste): Apply thin film bid/tid pc and hs
40-80 mg IM (studies have used 10 mg/mL diluted in 1 mL of lidocaine 2% to avoid tissue irritation and facilitate proper distribution of drug)
Pediatric Dose Not established
Contraindications Documented hypersensitivity; fungal, viral, and mycobacterial mucosal infections
Interactions Coadministration with barbiturates, phenytoin, and rifampin decreases effects; effects of vaccine and toxoid may be reduced
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Multiple complications (eg, severe infections, hyperglycemia, edema, osteonecrosis, myopathy, peptic ulcer disease, hypokalemia, osteoporosis, euphoria, psychosis, myasthenia gravis, growth suppression) may occur; abrupt discontinuation may cause adrenal crisis
Drug Name
Betamethasone valerate (Diprosone) -- For inflammatory reactions responsive to steroids. Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and by reversing capillary permeability. Affects production of lymphokines and has inhibitory effect on Langerhans cells.
Adult Dose Suggested dose: 0.05% topically q6h for 3 wk
Pediatric Dose Not established
Contraindications Documented hypersensitivity; paronychia; cellulitis; impetigo; angular cheilitis; erythrasma; erysipelas; rosacea; perioral dermatitis; acne
Interactions None reported
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Do not use in skin with decreased circulation; can cause atrophy of groin, face, and axillae; may cause striae distensae and rosacealike eruption; may increase skin fragility; rarely may suppress HPA axis; if infection develops and is not responsive to antibiotic treatment, discontinue until infection is under control; do not use monotherapy to treat widespread plaque psoriasis
Drug Category: Extravasation antidotes -- Can enhance the diffusion of locally irritating or toxic drugs in the management of intravenous extravasation.Drug Name
Hyaluronidase (Wydase Injection) -- Stimulates hydrolysis of hyaluronic acid, one of the chief ingredients of tissue cement, which offers resistance to diffusion of liquids through tissues. Used to aid in absorption and dispersion of injected drugs.
Adult Dose 150 U added to vehicle solution and administered SC/ID
Pediatric Dose Administer as in adults
Contraindications Documented hypersensitivity
Interactions Salicylates, cortisone, corticotropin, estrogens, and antihistamines may decrease effects
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Avoid injecting into inflamed or cancerous areas; perform intradermal skin test for sensitivity before initiating infusion; discontinue if sensitivity or extravasation occur
Drug Category: Interferons -- Are naturally produced proteins with antiviral, antitumor and immunomodulatory actions. Alpha-, beta-, and gamma-interferons may be given topically, systemically, or intralesionally.Drug Name
Interferon gamma (Actimmune) -- Believed to act via ability to counteract cell surface expression of proinflammatory or proadhesion molecules on immune cells, among other effects. More studies needed to fully understand mechanisms of action.
Adult Dose BSA >0.5 m2: 50 mcg/m2 SC 3 times/wk
BSA <0.5 m2: 1.5 mcg/kg/dose SC 3 times/wk
Pediatric Dose Not established
Contraindications Documented hypersensitivity; Escherichia coli derivatives or components
Interactions Live vaccines; rotavirus vaccine
Pregnancy C - Safety for use during pregnancy has not been established.
Precautions Caution in preexisting cardiac disease, seizure disorder, or compromised CNS function; myelosuppression  (+ info)

What are the benefits of oral acetylcysteine in pulmonary fibrosis?Does it help?

I had a patient that had to drink 600mg three times a day.She mixed it with her soda.She said her pulmonologist was giving her this for her pulmonary fibrosis.
I know the normal uses for acetylcysteine.I just haven't heard of this use before.

It's suppose to help preserve their diffusion capacity.Can't imagine having to drink that stuff.Here is link to more info.
http://www.medscape.com/viewarticle/517702  (+ info)

what do you mean by OSMF-ORAL SUB MUCUS FIBROSIS?

Oral submucous fibrosis: A rare disorder involving inflammation and progressive fibrosis of tissues inside the mouth. The condition starts with redness, blistering and ulceration inside the mouth that is eventually replaced with stiff fibrous tissue as it heals. The inside of the mouth can become stiff and hinder oral functions such as eating, speaking and even opening the mouth. Even the pharynx may occasionally be involved. The condition can become cancerous.  (+ info)

submucous fibrosis lycorate?

Do you mean Oral submucous fibrosis? One reason for this is chewing areca nuts (supari).  (+ info)

Does anybody have any information on or experience with submucous cleft palate?

I was just wondering if anybody has any information or experience with submucous cleft palate? It is a possible diagnosis for my two week old daughter who has been having problems feeding and now has been found to have a small scar look-a-like in her mouth. I have trawled the internet and not found very much. Anything at all would be a great help as it's very rare and the doctors don't have much of a clue about it.
Thanks in advance

With a submucous cleft palate, midline of the palate in your baby's mouth didn't come together properly inutero, but yet the tissue in her roof of her mouth grew over it. I put a source below that gives some helpful information about your baby's possilbe condition. Hope it helps to make things a little clearer for you!  (+ info)

I have symptons of Cystic Fibrosis. Is it possible to start show the symptons in my 30's?

I am having a hard time breathing and seem to have attacks that come on all of a sudden. Also I t feels like something stuck in my lungs..I cannot remeber any signs when I was growing up. Is it possible to start showing signs of cystic fibrosis in my 30's?

Yes, it is possible. Some of the previous answers are unbelieveable.
No, you don't have to be diagnosed prior to 2 years old and NO you don't have to spend your teenager years in the hospital. Some of you are reading out of a 1950's medical journal.
There are many different mutations with different manifestations.
There are MANY different forms of CF and there are documented cases of people being diagnosed in their 30's, 40's, 50's , 60's etc...
Good Look and I hope you find what is ailing you.  (+ info)

What is the average life expectancy for people with Cystic Fibrosis?

I'm pregnant with my first baby and I got some tests done and the doctors informed me that my daughter will have Cystic Fibrosis. My mother had a brother and sister who died from the disease when they were quite young. Anyway, I'm wondering what is the current life expectancy for children/people with Cystic Fibrosis and how can you best take care of them to maximize their life?

more than 37 years old  (+ info)

What is the difference between asbestosis and pulmonary fibrosis?

My husband has been advised by his consultant to claim industrial disease allowance for his pulmonary fibrosis.Has he worked in shipbuilding with asbestos we expected to be told he had asbestosis!Should we be pleased or is it two names for same illness? He has lost a lot of former colleagues to asbestosis and so we and especially me, are very concerned about his quality of life in the near future.

asbestosis is caused by exposure to asbestos asbestos fibres are thin and microscopic and easily pass through the filters in the nose and bronchi into the lungs it sticks to the lungs and scars the lung tissue it makes it harder for the lungs to function properly and gas exchange gas exchange in the lungs gets harder it can cause respiratory failure and can take years to develop
pulmonary fibrosis scars the tissue in the lungs eventually the air sacs in the lungs are all replaced by fibre or scar tissue this tissue is thicker and the tissuyes cant transfer oxygen to the blood anymore  (+ info)

What are the chances of a woman with cystic fibrosis to get pregnant?

I have cystic fibrosis and i was curious to know the percentage chance of a woman with this disease to get pregnant. i know we can conceive, but with men there is only a 2% chance of them getting their partner pregnant.

you could take a look on http://www.getpregnantguides.com/ . did a search on the internet and i found there some great guides  (+ info)

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