FAQ - Philadelphia Chromosome
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Why does the Philadelphia chromosome contribute to cancer?

The Ph chromosome is an abnormally short chromosome 22 that is one of the two chromosomes involved in a translocation (an exchange of material) with chromosome 9. This translocation takes place in a single bone marrow cell and, through the process of clonal expansion (the production of many cells from this one mutant cell), it gives rise to the leukemia.  (+ info)

If someone is diagnosed with Philadelphia chromosome and is taking gleevec without leukemia?

will leukemia still develop or will the gleevec fix the disorder

Gleevec treats leukemia patients (with CML) that are positive for the Ph chromosome specifically. Two things can happen to a CML patient taking Gleevec. The cancer can disappear completely for the rest of the patient's life, and the Ph chromosome becomes non-detectable even using advanced molecular techniques. This is called a molecular complete response. But more often, a few of the leukemic cells are resistant to the effects of Gleevec and they slowly take over and become the majority of cells. Then the patient has developed Gleevec resistant CML, and must choose a new therapy, such as Tasigna.
So to answer your question, sometimes Gleevec fixes the disorder and sometimes leukemia still develops. I'm sorry that this is probably not very satisfying. If the Ph-positive leukemic cells disappear from the bone marrow, this is a very positive prognostic factor.  (+ info)

If someone has the Philadelphia chromosome and they are being treated with Gleevec will the leukemia be gone?

Nope. Gleevec eventually stops working for most people who don't die of unrelated causes during treatment, and some patients discontinue using it before it stops working because of side effects.

It, along with tasigna and sprycel, offer much more effective treatment than the older generation of drugs, but they are by no means a cure.  (+ info)

Acute biphenotypic leukemia with philadelphia chromosome?

My daughter has been diagnosed with Acute Biphenotypic Leukemia a couple of weeks ago. Today, the hematologists told us that she also has the philadelphia chromosome. So, they have suggested that as treatment we proceed with a bone marrow transplant as our final course of treatment. I have a couple of questions regarding this, the first being.... What are the chances that the leukemia will relapse after the bone marrow transplant? How much does having the Philadelphia chromosome change these odds? Where is the Philadelphia chromosome located? Is it in the bone marrow? Is it part of the genetic make-up of the body? I am not understanding how exactly this chromosome is changing the prognosis. I guess part of the issue is that this type of leukemia is extremely rare, especially when coupled with the Philadelphia chromosome and the answers to be found anywhere are few and far between. They also want to start giving her the drug Gleevec. I guess what I am looking for in the end is some type of hope with the survivability of her cancer. Is a cancer free life obtainable for her?

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What chromosome is the genetic disorder Myofibrillar Myopathy on?

My father's mother has the disease, and I'm trying to figure out if it was passed to my Dad, my brother, and I. What chromosome is it on? Any other information is welcome, and if you know of a site where I can talk to a geneticist or other expert, please give me a link. Thanks!

It is inherited in an autosomal dominant manner, which mean your dad has a 50% chance to inherit it, and you have a 25% chance. As you dad gets older and lives through some of his risk, those chances go down. I great resource for genetic disorders is genetests.com. It can be hard to navigate if you're not used to it, so here's a link for you: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=mfm
Without knowing more details, or what you do/don't understand, I can't give more info right now. If you have specific questions, feel free to email me.  (+ info)

Is Philadelphia cream cheese or soft cheese? Or is that the same?

Im planning to make a carrot cake for my baby's first birthday and in order to make the frosting i need to use cream cheese. I went to Tesco to buy some but all I could find was Philadelphia soft cheese- said on it. Can I use it as a cream cheese, or is that cream cheese in real. Please help as the big day is coming, and I dont want to fail as a mummy.


Its the same  (+ info)

How can I find out if I carry the chromosome for agammaglobulinemia?

My father had agammaglobulinemia and my mom didn't. is there a chance I could carry the chromosome for agammaglobulinemia? And how can I find out for sure?

Serious answers please.

Ask your doctor to send you for genetic testing. Check with your insurance company first to make sure the testing is covered. It'll be $$$$$.  (+ info)

What is the difference between bone marrow biopsy and chromosome analysis?

Bone marrow revealed neutropenia and nurse said that they dont know what's causing it. Tested for every virus and negative. Waiting on chromosome analysis and what does that show?

"Lab Guy" has a superb answer.
C'mon Pedal7. You know these tests are completely different.
And you also know that it is impossible to test for every virus.
There are many hundreds of viruses. No one checks antibody levels for every one.
Relax and wait for the test results.
Be happy that no evidence of any type of leukemia was identified on the microscopic marrow examination.  (+ info)

What is the yellow colored juice under the philadelphia cheese?

I just started eating my bagels with philadelphia cheese and now i'm getting at the end of my first philadelphia pot. I just dig some cheese from the pot and i found under the cheese that there is some kind of yellow juice. I removed it and mixed all the cheese together and now it's creeping me out. What the hell is that yellow juice? It looks like melted butter.

Is the fruit of the cheese  (+ info)

Where can I buy Rockabilly clothing in the Philadelphia and/or surrounding area?

I am searching for Rockabilly type clothing and also old school diner waitress uniforms, stewardess dresses, etc. I have searched endlessly online, but hesitate to purchase online without being able to try items on. If you know a store in the Philadelphia area (including surrounding suburbs) please let me know. If you know a good online store, you can pass that along as well. Or maybe you know someone that makes clothing like that. Any info at all would be most appreciated. THANKS!


Try this link!! i hope this helps....good luck!  (+ info)

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