FAQ - Poliomyelitis, Bulbar
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Where in the world can poliomyelitis be found?

Also, how can it be treated, what pathogen causes the disease, and some history about poliomyelitis.

India, Afghanistan, Pakistan, and Nigeria are the only places where it is endemic.

There are people in developed countries who come there for treatment. But it's been a long time since polio has existed in a lot of places.

People are attempting at the moment to eradicate polio the way people did to smallpox back in 1977. All through 2010 there are going to be a lot of vaccinations of people. Poliomyelitis could become the second-ever disease to be eradicated.  (+ info)

What is the main problem in poliomyelitis?

A 10 yr old boy had flu-like symptoms for 5 days(fever, headache,body malaise and muscle soreness). when fever subsided, he had difficulty in getting out of bed and walking.Two weeks after, the limp became more prominent which later progressed to weakness.The left leg was noted to decreased in size after 2 months. He was diagnosed to have poliomyelitis.

What is the main problem in poliomyelitis?
In poliomyelitis, are action potential generated from motor end plate?
What is the cause of muscle atrophy?

I think you need a textbook. Look it up on wikipedia too. It looks like it's polio :) The nerves are de-mylenated in some disorders, probably polio too. That means the protective cover on the nerves is destroyed, which means the body can't use the muscles attached to the nerves (no signals or poor signals) and so muscles will become smaller without use - it's what naturally happens to astronauts even.  (+ info)

What vitamin are you deficiant in with Progressive Bulbar Paulsy?

It is said that PBP is a "vitamin dependent" Disease and that massive doses of a certain vitamin will begin to reverse it

Onset age 50-70 years

Subtype of Amyotrophic Lateral Sclerosis (ALS)
Cranial Nerve motor nuclear atrophy, glial overgrowth
Cranial Nerve 5
Cranial Nerve 7
Cranial Nerve 9
Cranial Nerve 10
Cranial Nerve 12
Subcortical involvement of corticobulbar tracts

Difficult chewing
Nasal regurgitation

Arm and leg spasticity
Hyperactive reflexes
Fasciculation of Tongue and lip muscles
Emotional lability

Differential Diagnosis
Acute bulbar paralysis
Acute CNS vascular lesion (hemorrhage or thrombosis)
Acute Bulbar Polioencephalitis
Chronic bulbar paralysis
Multiple Sclerosis

Progresses to Aspiration Pneumonia, respiratory arrest
Death in 1 to 3 years from onset

Comment added by Richard W. Webb on 2/27/04
I'm being treated at UCSF. I've been told that Progressive Bulbar Palsy (my diagnosis) is "onset ALS". Go to this web site for information, hope, and help. Print out all 21 pages and study it. I've tripled the recommended dose of Vitamin E.


Good Luck to your dad,

Richard Webb  (+ info)

Why do AIDS children be isolated from those who have had Poliomyelitis?

AIDS children are risky of developing opportunistic infections.

Because Aids affects their immune system so they're not able to fight other infections. So they would be at risk of developing Polio.  (+ info)

Why is Spinal Bulbar Muscular Atrophy nicknamed Kennedy's disease?

I am having to do a Biology research project on Kennedy's disease, Spinal Bulbar Muscular Atrophy. I was wondering why SBMA was given the nickname Kennedy's disease. Any information relating to this mystery would be so helpful! thanks!
Nevermind. I found the answer I was looking for. But if you know any interesting facts about this disease please share!

Dr. William Kennedy is now retired, but still interested in spinal bulbar muscular atrophy (SBMA). Last winter, he wrote the Kennedy's Disease Association and commented, "
"I am amazed at the wonderful support that the KDA gives to the men and families affected by KD. The progress made by current research on animal models of KD and by therapeutic trials gives reason to hope that the disease that I described 40 years ago will finally be conquered."

Many people are still misdiagnosed today (most often as ALS). This link talks a little about that:

The genetics side of KD is interesting. In this link I try to explain it further: http://kennedysdisease.blogspot.com/2010/01/genetic-counseling-helps-to-answer-many.html

IGF-1 is a pretty exciting potential treatment for KD. If the next round of testing goes well, we could have a clinical trial by the end of the year. These two links explains it further: http://kennedysdisease.blogspot.com/2010/01/delaying-motor-neurone-disease.html

This is an interesting story about the need for educating care givers: http://kennedysdisease.blogspot.com/2009/09/education-and-awareness.html

There is quite a bit of information on the KDA web site.
I hope this helps.  (+ info)

Can acupuncture help for Progressive Bulbar Palsy?

I found a Chinese medical study suggesting Acupuncture had good results for symptoms of Bulbar Palsy, but it was a very small study and was published way back in 1996.
There seems to have been no further research even though the results seemed promising. Maybe the paper didn't stand up to peer review, or was proven to be flawed somehow.

So I'm wondering if anyone knows if acupuncture can ease speech and dysphagia/swallowing problems with Bulbar related neurological diseases?


Acupuncture may be able to temporarily arrest, or reverse, dysphagia in PBP cases. In studies treatment has been shown to have a positive effect on dysphagia in post-stroke patients,and although the diseases are separate it does illustrate acupuncture can have a positive effect on restoration of function when neurological damage has occurred.

Due to the progressive nature of Bulbar Palsy, I would say that positive outcomes from acupuncture would not be a permanent. Treatment would be focused on improving quality of life for as long as possible.

Here is a link to a 2003 study published on Acupuncture and Dysphagia in the Medical Acupuncture Journal: http://www.medicalacupuncture.org/aama_marf/journal/vol14_3/article3.html  (+ info)

What are the last stages of Motor Neurons Disease, possible type Progressive Bulbar Palsy?

It progresses to aspiration pneumonia, then respiratory arrest.  (+ info)

Does anyone know a person who has Bulbar ALS?

My Brother was just diagnosed with this and I'm wondering what can be expected

Hope this helps...
http://www.als.ca/manual-managing-treating.shtml  (+ info)

Poliomyelitis, i have no clue what it is...?

I have an assignment for biology, and im doing a disease on poliomyelitis, the thing is, i don't know anything abot it. can someone please help me. and IF possible, could they explain in french? but it doesn't have to be in french.

Poliomyelitis, often called polio or infantile paralysis, is a virally induced infectious disease which spreads via the fecal-oral route. It may proceed to the blood stream and into the central nervous system causing muscle weakness and often paralysis. An ancient disease, it was first recognized as a medical entity by Jakob Heine in 1840. Vaccination and eradication efforts led by the World Health Organization and The Rotary Foundation of Rotary International are credited with the reduction of the number of annual diagnosed cases from the hundreds of thousands to around a thousand.  (+ info)

Why poliomyelitis always triggers the lower extremities?

Why affected individual usually experiencing slow deterioration oftheir legs?

Poliomyelitis is caused by a virus that travels toward the anterior horn of the spinal cord which is the sites for nerves that innervate yout bodily muscles. THe virus destroys these nerves (called lower motor neurons) leading to muscular paralysis and atrophy (srinking). The spinal cord has 2 enlargements, the cervical for the upper limb and the lumbar for the lower limb. The lumbar enlargement is bigger than the cervical and thus, more susceptive to viral infection. There are individuals that can get polio in the cervical enlargemens or in both sides as well. Lower motor neurons are like "life force for the muscles they innervate; with nerves, the muscles become paralyzed and shrink (called flaccid paralysis). We call that the "trophic function of nerves"!!  (+ info)

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