FAQ - Stevens-Johnson Syndrome
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a doctor recently gave me a possible diagnosis of Stevens Johnson syndrome?

I have subsequently stopped taking Duloxetine for 4 weeks now , yet persistant symptoms skin lesions started that looked like larva migrans, then turned vericula and some very painful with creeping feeling under my skin and also stomach cramps dihorrea, also low hb and iron , previously had to have a transfusion, had a gastroscopy but no colonoscopy, stool samples have returned normal results.

I'm afraid I don't know a whole lot about your condition, but it sounds serious and it is sad to hear esp. at this time of year. Happy Holidays!!! If possible that is.  (+ info)

What is the treatment for Stevens Johnson Syndrome?

i never got anything from my doctors i know they were suppoused to i could have died.

Please see the webpages for more details on Erythema multiforme ((Stevens-Johnson syndrome).  (+ info)

What is the com on cause of Stevens-Johnson syndrome all over the World?

Can it kill? Can it cause permanent damage? Is it mainly occupational? Can I be get it through infection? Does a certain race predisposed to develop this condition? What races would it be more common? Who are Drs. DStevens and Johnsons? Thank

its caused by an allergic reaction to antibiotics
yes it can be fatal
not spread thru infection
unsure if certain races are predisposed
don't know who the doctors are  (+ info)

Can Stevens-Johnson Syndrome be a side effect of Ibuprophen?

IB is considered an NSAID and this syndrome can come from a reaction to NSAIDs but as you will see from the exerpt from a website below - it does not mention IB as one of the drugs that can cause this. However IB IS an NSAID which CAN cause this so I am sure it would be possible but not in this case.

Your friend is not suffering the other symptoms like severe anxiety, pain, etc.. and the others that come up when you search for this syndrome online. Your friend is having an allergic reaction to something and if this is scaly - is it psorasis. I guess it would be possible BUT your friend is not having these other symptoms so it is most likely - not this but only a doctor - a dermatologist would be able to rule this out 100%. Also - this syndrom is fatal and your friend is just exhibiting a rash behind his ears - not excessive pain, etc - read below for all of the symptoms - none of which mention a rash behind the ears - at all since the ears - behind the ears is NOT a mucous membrane.- which this syndrome does involve.

Steven Johnson syndrome involves mucous membranes - mouth, nose, throat, privates, etc - anywhere your body is wet essentially - this is NOT this syndrome - not at all. Although -it can involve skin lesions, the way you describe their syptoms indicate psoriasis not this - I doubt it - pretty certain this is NOT it - the other one is much more common and is often found in the location you mention and also under the hairline, under the hair, around it, etc.

Symptoms of Stevens-Johnson Syndrome
Typically, Stevens-Johnson syndrome affects the mucous membranes of the oral cavity, nostril, eyes, and both the anal and genital regions. It may or may not be associated with skin lesions elsewhere on the body. Oropharyngeal (mouth) lesions may be so intolerable as to prevent eating, and there may be recurring oral ulcers. Often, the skin lesions may look like a target-lesion (3 concentric zones of color change) or as bullae (bubble-like).

A painful conjunctivitis may occur in the eye, frequently with a pus discharge, and can lead to corneal scarring and loss of vision. In addition to the mucous membrane lesions, fever and exhaustion are usual.

Approximately one-third of patients have pulmonary involvement with cough and patchy infiltrates (material that has permeated into the tissues) on chest x-ray. In fatal cases, renal failure and pneumonia may occur.

Stevens-Johnson Syndrome is a potentially deadly skin disease that usually results from a drug reaction. Another form of the disease is called Toxic Epidermal Necrolysis, and again this usually results from a drug-related reaction. Drugs that have been linked to Stevens-Johnson Syndrome include NSAIDS (non-steroid anti-inflammatory drugs), Allopurinol, Phenytoin, Carbamazepine, barbiturates, anticonvulsants, and sulfa antibiotics. In some cases, the condition is caused by a bacterial infection, and in many cases there is no known cause for the onset of Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis.

These skin diseases can cause massive pain, suffering and anxiety. People that have taken or are taking medications such as the ones mentioned above are urged to familiarise themselves with the symptoms of SJS (Stevens-Johnson Syndrome) and Toxic Epidermal Necrolysis (TEN). This will enable you to seek immediate medical attention should the need arise, and early initiation of treatment can make a big difference to the seriousness of the disease as this can stop any secondary infections.

The aim of this site is to keep people informed about the symptoms, causes and treatment of SJS and TEN, and also to offer advice with regards to the legal options of those affected by these diseases. You can find out more about various aspects of these diseases through the following articles:

http://www.skinassn.org/  (+ info)

can iv glutathione be a cause of stevens-johnson syndrome?

and so does taking glutathione orally?

As I take glutathione precursor supplements, I was quite curious about your question.

From the reports that I've read (one of which is noted below) I have not found any research linking iv glutathione or oral glutathione to Stevens-Johnson Syndrome (SJS).

It would appear that the primary causes of SJS are:

Infectious, drug induced, malignancy-related and idiopathic and none of the drug induced causes (that I read about) of SJS make reference to glutathione, IV or oral. That isn't to say that secondary elements in the IV or in an oral mix are not the cause.

You should consult with a medical practitioner who specializes in SJS and its causes to get a more complete response.  (+ info)

what was the first known case of STEVENS-JOHNSON SYNDROME?


It was first discovered in 1922 by pediatricians A.M.
Stevens and S.C. Johnson after diagnosing a child with severe ocular and oral involvement to a drug reaction.

It's a horrible disease. I work in a hospital pharmacy and I see these patients sometimes. It's so sad.  (+ info)

whats the death rate of stevens johnson syndrome??

my sister was just diagnosed with stevens johnson syndrome and i'm scared it could be fatal, she's in really bad shape she's completely swollen and in pain and can't really breathe, does anyone know about this..


53% Die of Steven Johson Syndrome...

What is Stevens-Johnson Syndrome (SJS)?
Stevens-Johnson Syndrome (SJS) is a severe and lifethreatening condition and has been known to be caused by taking certain medications. It is a serious systemic disorder with the potential for severe symptoms and even death, and can affect the oral, nasal, eye, vaginal, urethral, GI, and lower respiratory tract mucous membranes during the course of the illness.

What are the symptoms of Stevens-Johnson Syndrome (SJS)?

Stevens-Johnson Syndrome (SJS) causes blisters, may lead to blindness, and possibly death. Approximately 1 in 3 people survive from Stevens-Johnson Syndrome (SJS). The disease can also cause organ damage.

Typically, initial symptoms of the disease begin with a nonspecific upper respiratory tract infection. Fever, sore throat, chills, headache, and malaise may be present. Vomiting and diarrhea are also occasionally noted.

Lesions of the mucous membranes can develop abruptly. If the infection has afflicted the oral and/or mucous membranes, it may be severe enough that patients may not be able to eat or drink. Though lesions may occur anywhere, the palms, soles, and hands are most commonly affected.

Rashes may also develop. They may be confined to any one area of the body, most often the trunk.

If any of the following symptoms occur, consult with a doctor immediately:

Altered level of consciousness
Corneal ulcerations
Erosive vulvovaginitis or balanitis

Stevens-Johnson Syndrome (SJS) is often associated with high death rates. People with severe Stevens-Johnson Syndrome die in 53% of cases. Even with treatment, permanent skin damage and scarring, organ failure, and inflammation of the lung, heart, kidney or liver, and other complications may occur.

Who does Stevens-Johnson Syndrome (SJS) normally afflict?

Stevens-Johnson Syndrome (SJS) is reportedly known to afflict as many as one million people each year. Though viral infections can cause this rare condition, Stevens-Johnson Syndrome (SJS) is commonly caused by severe allergic reactions to either prescription (antibiotics and sedatives) or over-the-counter medications such as Advil and Ibuprofin. It is believed that Non Steroidal AntiInflammatory Drugs (NSAID's) including Daypro (Oxaprozein), popular COX2 inhibitors like Vioxx (Rofecoxib), Celebrex (Celecoxib), and Bextra (Valdecoxib) are a leading cause of the disease.

On May 16, 2006 the Food and Drug Administration released an updated warning label for several prescription and over-the-counter (OTC) medications as a result of increased risk of developing Stevens-Johnson Syndrome. The following now have either a new warning regarding Stevens-Johnson Syndrome or additional language to their labeling:

Advil Allergy Sinus Tablets (200 mg ibuprofen / 30 mg pseudoephedrine HCI / 2 mg chlorpheniramine maleate)
Advil Cold & Sinus Tablets (200 mg ibuprofen / 30 mg pseudoephedrine HCI)
Advil LiquiGels (200 mg ibuprofen capsules)
Advil Migraine Capsules (200 mg ibuprofen)
Children's Motrin Chewable Tablets (50 mg ibuprofen)
Motrin Junior Strength Chewable Tablets (100 mg ibuprofen)
Motrin Cold & Sinus Tablets (200 mg ibuprofen / 30 mg pseudoephedrine HCI)
Motrin IB Tablets (200 mg ibuprofen)
Motrin Infants' Drops (50 mg / 1.25 mL ibuprofen oral suspension)
Tolectin 600 Tablets (Tometin Sodium)
Tolectin DS Capsules (Tometin Sodium)

Other drugs known for potentially causing Stevens-Johnson Syndrome include, though are not limited to:

Arava/ Leflunomide
Bextra/ Valdecoxib
Celebrex/ Celecoxib
Clinoril/ Sulindac
Daypro/ Oxaprozin
Enbrel/ Etanercept
Feldene/ Piroxicam
Lamictal/ Lamotrigne
Naprosyn/ Naproxen
Remicade/ Infleximab
Serzone/ Nefazodone
Vioxx/ Rofecoxib.

Have you, a friend or a loved one been diagnosed with Stevens-Johnson Syndrome (SJS)?

Stevens-Johnson Syndrome (SJS) is commonly associated with drug-induced allergic reactions. If you have developed Stevens-Johnson Syndrome (SJS) because of a prescription medication like Vioxx, Bextra, Celebrex, etc. or an over-the-counter (OTC) medication like Motrin, Advil, or Ibuprofin, contact a lawyer for more information about your rights. Depending on the situation, you may be entitled to compensation.  (+ info)

What kind of antibiotics can a person with Stevens Johnson syndrome take when they have an respiratory infect.

Stevens Johnson Syndrome is a serious skin eruption that is usually in response to some medication taken (a severe reaction).
Once the reaction is taken care of and medication out of the system and the person completely recovered, they no longer have Stevens Johnson Syndrome.
However, if the same person took the same medication, they could again have a severe reaction and develop Stevens Johnson Syndrome yet again...or even have a worse reaction, potentially even dying.

The difficulty with answering your question is that every person is different. The vast majority of people can take any and all medications without developing Stevens Johnson. i.e. It is EXTREMELY rare. Except for dermatologists, the average doctor might see it 5 times in a lifetime (if that).

A person predisposed to Stevens Johnson Syndrome (i.e. they have had it before), should only avoid medications that they have that reaction too.

One person might react to one type of medication (sulfa drugs), but not to other types of drugs (penicillins). Another person might be exactly the opposite.

Therefore, the class of drugs that they have reacted to before should be avoided.

One of the most "common" (yet still very rare) medications often associated with SJS and used for respiratory infections would be Bactrim.

However, ANY of the medications used for ANY infection could potentially cause SJS in an individual...

I hope this is somewhat clear...  (+ info)

Is Stevens Johnson Syndrome contagious?

I run a day care, and one of the kids I watch has it, so I need to know if it is. So I can tell the parents.

No it is not contagious. It is usually caused by medication a person is taking--a severe reaction to them, some cancers, or some infections. The infections that could have caused this child to develop SJS could be contagious, but I would wait to find out from the parents if there was an underlying infection like with the Epstein-Barr virus which causes mono to have this child develop this very serious skin condition. So don't panic. He can not give anyone else SJS. Hope this eases your mind some.  (+ info)

how can the effects of stevens-johnson syndrome be treated from the skin?

black spots and pigmentation like burns on the skin

You say 'black spots and pigmentation like burns' as though that's what it was...Stevens-Johnson's syndrom is an allergic reactions, usually from antibiotics. It is REALLY scary, and not too many people recover completely. First thing, stop the antibiotics. This will prevent any further blistering. Some of these things you refer to as pigmentation like lesions, get very large. Second, they get moved to the ICU and are treated as an EMERGENCY. A doctor will usually try to figure out where the lesions are internally, and then treat them as nescesary. They can be anywhere there's a mucous menbrane, including the lungs, trachea, intestines, stomach... you name it. Sometimes they will lance them internally because if they get too big, the flaps of skin left over from when it bursts can cause obstruction. This is actually how many die from the disorder. Infection though, is the number one culprit for killing patients with this. I mean, think about how easily a surgical wound can get infected... now imagine taking care of multiple secondary wounds daily.... on top of that, the person usually already has some type of infection becasue they were receiving antibiotics, which is what caused it in the first place. There really isn't any specific treatment except fluids, careful monitoring and good surgical and medical asepsis.  (+ info)

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