what is Hereditary Hemorrhagic Telangiectasis?
All I know is that its a disease that deals with blood.
Hereditary Hemorrhagic Telangiectasia (HHT) is a genetic disorder of the blood vessels which affects about one in 5,000 people.
Most blood vessels in the body of someone with HHT are normal. However, a small percentage of the blood vessels in a person with HHT have a specific type of abnormality.
Blood vessels are the tubes that carry blood around our bodies. There are two types of blood vessels: arteries and veins. Arteries carry blood under high pressure out to all areas of the body after being pumped by the heart. Veins carry blood that should be under low pressure, on its way back to the heart. An artery does not usually connect directly to a vein. Usually there are very small blood vessels called capillaries that connect an artery to a vein.
A person with HHT has a tendency to form blood vessels that lack the capillaries between an artery and vein. This means that arterial blood under high pressure flows directly into a vein without first having to squeeze through the very small capillaries. This place where an artery is connected directly to a vein, tends to be a fragile site that can rupture and result in bleeding. We usually call a blood vessel that is abnormal in this way a telangiectasis (tel-AN-jee-eck-TAZE-ee-ya), if it involves small blood vessels. We tend to call it an arterioveneous malformation (AVM) if involves larger blood vessels. So, an AVM might be thought of as a big telangiectasis. The basic abnormality in the blood vessel is the same.
Telangiectases tend to occur at the surface of the body such as the skin and the mucous membrane that lines the nose. AVMs tend to occur in the internal organs of the body. The telangiectases (plural for telangiectasis) and AVMs of HHT occur primarily in the nose, skin of the face, hands, and mouth and the lining of the stomach and intestines (GI tract), lungs and brain. It is not currently known why these abnormal blood vessels tend to occur in certain parts of the body and not others. (+ info
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The main factors that play a role in the development and continuity include;
Heredity- Where family history plays a part in individual development.
Age - The development of spider veins may occur at any age but usually occurs between 18 and 35 years, and peaks between 50 and 60 years.
Gender – Females are affected approximately four to one to males.
Pregnancy – Pregnancy is a key factor contributing to the formation of varicose and spider veins. The most important factor is circulating hormones that weaken vein walls. There's also a significant increase in the blood volume during pregnancy, which tends to distend veins, causing valve dysfunction which leads to blood pooling in the veins. Moreover,later in pregnancy, the enlarged uterus can compress veins, causing higher vein pressure leading to dilated veins. Varicose veins that form during pregnancy may spontaneously improve or even disappear a few months after delivery.
Lifestyle/Occupation - Those who are involved with prolonged sitting or standing in their daily activities have an increased risk of developing varicose veins. Therefore, the weight of the blood continuously pressing against the closed valves causes them to fail, leading to vein distention.
The lifestyle factors that can contribute to the development of varicose and spider veins entail: (+ info
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