FAQ - acidosis, lactic
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ER did blood work but not looking for anything specific would they have seen if I had Lactic Acidosis?

Accidentally took took double the Metformin XR for the last week and feel faint, dizzy, light headed and have slight leg cramping. I have also been on a plane for 6 hours on Tuesday. I went to the ER for dizziness and they couldn't find anything. Now I am worried about LA. I am so afraid, please help.

I have only seen a few true cases of lactic acidosis from Metformin use. There are a couple things that can increase your risk for LA. If you are aware of your lab results, then one of the lab values you should look at is your serum creatinine (Scr) - if it is greater than 1.4 then you should not be taking Metformin any longer. Also, it is possible to directly measure the amount of lactate in the blood. I'm assuming that they would not have discharged you if it had been abnormal.

Be aware that the recommend maximum dose for Metformin XR is 2000 mg per day.  (+ info)

Diabetic relative diagnosed w/lactic acidosis, still eating sugar, what is the typical rate of decline?

He's got a fragile ego, explosive temper... I would like to intervene somehow but I guess there's no way.

table sugar is the least of our worries! I am still having jelly and jam on my toast and putting sugar in my tea.

It is the other things in our food plans that will hurt severely! Root Veggies, grain and cereal products, milk products, and soft sweet fruits.

Your relative with the HYPERglycemia for sure has fragile ego and explosive temper from the high glucose levels. I did too when mine was high!

Does your relative use internet? this site might help him, and will definitely help you to attempt to help him. http://www.phlaunt.com/diabetes
Very concise, up to date, extensive and the most help I got from anyone or any place.  (+ info)

Can someone explain the pathophysiology of how diabetes mellitus causes lactic acidosis?

Lactic acidosis is the most common cause of metabolic acidosis in hospitalized patients. It is associated with an elevated anion gap and a plasma lactate concentration above 4 meq/L. Impaired tissue oxygenation, leading to increased anaerobic metabolism, is usually responsible for the rise in lactate production. (See "Approach to the adult with metabolic acidosis").

The pathophysiology and causes of lactic acidosis will be reviewed here. The possible role of bicarbonate therapy in such patients is discussed separately. (See "Bicarbonate therapy in lactic acidosis").

PATHOPHYSIOLOGY — A review of the biochemistry of lactate generation and metabolism is important in understanding the pathogenesis of lactic acidosis. Both overproduction and underuse of lactate appear to be operative in most patients.

Lactic acid is derived from the metabolism of pyruvic acid; this reaction is catalyzed by lactate dehydrogenase and involves the conversion of NADH into NAD+ (reduced and oxidized nicotine adenine dinucleotide, respectively). Normal subjects produce 15 to 20 mmol/kg of lactic acid per day, most of which is generated from glucose via the glycolytic pathway or from the deamination of alanine [1,2].

Lactic acid is rapidly buffered, in part by extracellular bicarbonate, resulting in the generation of lactate. In the liver and, to a lesser degree, in the kidney, lactate is metabolized back to pyruvate, which is then converted into either carbon dioxide and water (80 percent, catalyzed in part by pyruvate dehydrogenase) or glucose (20 percent, catalyzed in part by pyruvate carboxylase). Both of these processes result in the regeneration of the bicarbonate lost in the initial buffering of lactic acid.

And now you know the rest of the story !  (+ info)

Should I worry about Lactic acidosis if my leg got oddly stiff while I was sleeping today?

I got really tired after I ate today, so I went to take a nap. My leg didn't get really numb or anything....it just cramped a little, so I moved to a different position....but like I said, when I woke up, I couldn't walk because my leg was so stiff....

I take Metformin for PCOS

Metformin typically causes lactic acidosis only when you've overdosed on it or your kidneys have shut down, if you're on the right dose and you're peeing ok and feeling otherwise well, i doubt it is lactic acidosis

If you are really concerned a doc can do a quick blood test to rule it out (venous blood gas)  (+ info)

What is lactic acidosis in type 2 diabetics?

A potentially fatal condition which can be precipitated by a bad reaction to Metformin/Glucophage: http://en.wikipedia.org/wiki/Lactic_acidosis  (+ info)

lactic acidosis because of alcohol while on Metformin?

I've been trying to find information about alcohol and metformin. Some sites have said that lactic acidosis will happen, while other personal accounts have said that their tolerance level just dropped.

I'm by no means a heavy drinker, in fact I maybe drink 1/4th a bottle of beer a month, but I wasn't sure of how much alcohol can be drank before lactic acidosis. I figured maybe it would take a lot but I want to make sure. I wouldn't want it to be one of those two sips and you take a chance deals, but I'm sure it probably is...

So....how much alcohol before this happens?

I would imagine that it takes quite a few drinks before lactic acidosis occurs considering only about 1 in 33,000 people taking metformin experience lactic acidosis.
Certainly I would avoid drinking every day or having a bunch of drinks in a short period of time, but I'm sure you could have at least one drink with no problems (you should probably keep a close eye on your glucose levels after that drink, just to make sure).  (+ info)

lactic acidosis question?

Do you think lactic acidosis may be linked to a bradyasystolic rhythm due to hypoxia from respiratory emergencies?

Most likely.  (+ info)

What is lactic acidosis?

What exactly happens? What are the symptoms? I know it has something to do with your blood but I'm not exactly sure what happens. If anyone could tell me that would be nice. Also, can it kill you? If so.. how?

It is a condition caused by the buildup of lactic acid in the body.

Symptoms of lactic acidosis: upset stomach, weakness, fatigue, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.

Lactic acid levels get higher when strenuous exercise or other conditions—such as heart failure, a severe infection (sepsis), or shock—lower the flow of blood and oxygen throughout the body.
Lactic acid levels can also get higher when the liver is severely damaged or diseased, because the liver normally breaks down lactic acid.

Very high levels of lactic acid cause a serious, sometimes life-threatening condition called lactic acidosis. Lactic acidosis can also occur in a person who takes metformin (Glucophage) to control diabetes when heart or kidney failure or a severe infection is also present.

Lactic acidosis is an uncommon condition that happens when the body holds onto more lactic acid than it can handle. The cells in the body normally work by processing glucose and fat in order to use energy. However, a byproduct of this process is lactic acid. If there are problems within the mitochondria in the cells---the parts responsible for this processing task---lactic acid might build up and reduce the oxygen levels in the body. This reduced oxygen level can produce some nasty symptoms. Some causes of lactic acidosis include kidney failure, respiratory failure, some medications including those used to treat AIDS and even vigorous exercise. In order to be on the alert for this condition, it's important to have a good grasp of the warning signs and symptoms associated with it.

http://www.ehow.com/about_5100647_lactic-acidosis-symptoms.html?ref=fuel&utm_source=yahoo&utm_medium=ssp&utm_campaign=yssp_art  (+ info)

Lactose Intolerance, Or Lactic Acidosis? (TMI?)?

Ok, this question is a little TMI, but I wanted to get some opinions before I go running to the doctor thinking something's seriously wrong with me.
I used to be able to eat as much dairy as I wanted, and I ate alot of it. Milk with every meal, cheese, yogurt, ice cream, you name it and I love it if it's dairy.
But, I also had a little imbalance with my blood sugar and it was always low because my c-peptides prevented my insulin from working right. (Too much c-peps.)
SO, now I take Metformin (Glucophage) to regulate my glucose so I'm not always dropping so low, it makes it so my body can break down what I eat.
But now I can't eat nearly as much dairy. Maybe a glass of milk in the morning and a little ice cream at night but that's about it. I've had to cut down way more than half.
If I eat too much dairy, I'll get the runs really bad.
Have I become lactose intolerant as I've gotten older (I'm 28) or is this lactic acidosis because of the blood sugar meds?

Lactic acidosis does not necessarily cause diarrhea. Think of when you have had extended anaerobic exercise - those are the symptoms of lactic acidosis. Muscle pain and cramps are the big thing with this problem.

Metformin commonly causes diarrhea as a side effect. You might want to consider trying a different oral hyperglycemic agent if it is bothersome. Discuss this with your physician.  (+ info)

Do I have lactic acidosis?

Hi there! I'm currently on metformin for PCOS. I take 1000mg a day, and ive been on it for a month. Lately I've been feeling extremely tired, and I've been having leg cramps on and off. They're not like the leg cramps I've gotten before, like "charley horses" ect, like when you're dehydrated. It feels like someone is putting a sharp pressure on my legs, not exactly painful- just extremely uncomfortable.
I've also had about 3 dizzy spells, where ive just been going about my day and i just all of a sudden feel like the room is spinning for about a minute.
AND ive also been very tired lately. Does it sound like I could be in the early stages of lactic acidosis? im waiting for a call back from my doc- he wants to UP the metformin to 3 times a day, but i just dont feel like thats a good idea!! thanks for any input!!

Sounds like your iron is low. You should be drinking a lot of water, which helps to not feel so faint.

Low iron also makes you feel very tired, although it's sometimes not a sleep-tired. Just exhausted feeling that you want to lay around all day.

Have your doctor do a blood test and get some iron!

Proper diet and exercise is the only way to stay healthy.  (+ info)

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