FAQ - carcinoma, adenosquamous
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Recurrance rate for stage 2B cervical adenosquamous carcinoma?


In June, I was diagnosed with stage 2B cervical adenosquamous carcinoma, poorly differentiated. I had a PET Scan which showed 1 positive node but several nodes that were very suspicious, probable that they were also cancerous. Those were located from my pelvis and extending to iliac and para-aortic nodes. I had a tiny amount of parametrial involvement, no other tissues affected, but the cancer had deeply invaded throughout cervix and endocervical canal.

I underwent 7 weeks of chemosensitization with Cisplatin (every Monday, once a week), 6 weeks of external radiation (5 days a week) and 2 weeks of HDR Brachytherapy (internal radiation) with Smit sleeve implantation.

Its been 10 weeks since my treatment has ended, and I just had my first PET scan at 8 weeks to follow up. I now have no positive nodes, and one tiny spot still lighting up on the lower portion of the cervix but after further examination my doctor didn't see anything suspicious and thinks it's probably false alarm. I am awaiting another follow up PET scan in March, which will see if the radiation (which keeps working after treatment) may have taken care of that tiny area still showing activity.

My question is, after all I've been thru, what are the chances that I will be cured? What are the recurrance rates (by years also)?

Unfortunately I am extra worried because I am no longer eligible for a reasonably priced health insurance. BCBS is the only one who will insure me, and they want more $ than I make in a month just to insure me. I am worried I will not be able to get the follow up surveillance like my doctor wants to do. I just want to know what my chances are that I am really cured, for good?

I'm 27 years old, I am otherwise healthy despite losing 30 pounds from this illness. I can finally walk again and finally have a little energy. Please help.
I also thought I should mention that this was a very aggressive cancer. I was at the doctor 18 months prior and had a clear pap, and I have NEVER had anything abnormal show up. Not sure if it was there the whole time and kept getting missed or if it was truly that aggressive.
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I’m sorry to say it is probably really that aggressive. The differention of the cells determines how aggressive it is and poorly differentiated is quite aggressive. You also have an unusual type of cancer as most (80%) are squamous cell, with the next most common being adenocarcinoma and your cancer is a combination of the two. Did you have HPV? Was it strain 18? These are more likely to behave this way. Only a small percentage progress this quickly. You received the best known treatment which reduces the risk of recurrence by 30-50% and increases the 3 year survival rate by 10-15%. Your actual risk of recurrence I’m not sure of my best guess is under 30%. Best wishes I hope you do well.  (+ info)

Is adenosquamous carcinoma called glassy cell or clear cell?


My doctors never even told me the details of my cancer, I was transporting my own medical records from one doc to another and I read thru them and found all of my info.

I read that I have adenosquamous cervical carcinoma, poorly differentiated. I've been told that the poorly differentiated portion means that it is very aggressive. The adenosquamous portion I've read is a mix of squamous cell cancer and adenocarcinoma which is glandular.

I've been reading online and a lot of sources make it sound like adenosquamous carcinoma is a clear cell cancer or glassy cell cancer. I've also read that these are the cancers with the worst prognosis, respond the worst to treatment, recur more often than others, and overall are just the worst to have. I don't know if thats what I have.

My doc quoted me a cure rate of 85-95%, he is my oncologist. My radiologist told me he was way off and I would be lucky to have a 50/50 chance of cure.

Well here we are 3 months after treatment and it seems as if I am at least close to a cure. My pet scan showed a tiny speck which they said can be removed surgically if necessary, no more lymph node involvement or parametrial involvement.

But do I have this glassy cell cancer they talk so horribly about? If so, I want to be extra aggressive with my doctors in demanding more follow up than a regular CC patient. Thanks in advance.
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Adenosquamous carcinoma, clear cell and glassy cell are 3 different things. If you had clear or glassy cell it would clearly say so on your path report. Adenosquamous of the cervix does not often occur, but clear cell and glassy cell are very rare. The histology of your cancer was determined long ago this is the basis of your treatment, you should have also been told the details before treatment began. I am very surprised an oncologist would say there is an 85-95% cure rate, as cancer is not often discussed in terms of cure unless it is a very early stage or a non aggressive cancer. It is usually discussed in terms of survival rates and it is not 85-95% in your case. I think you need to have another talk with your oncologist.  (+ info)

What are the chances of a 27 year old getting stage 2B adenosquamous cervical carcinoma?


Best answer to whoever wants to do the math...just wondering how rare I actually am.
oh and P.S.

It went from nothing to stage 2B in 18 months, it is believed since there was no sign of it prior to that, pap was normal. And cells were "poorly differentiated" which I already know means aggressive.
It rarely affects those under 30 though...average age is in the 50's.

I know at least 80% are squamous cell
Then 10-20% are adenocarcinomas
and within that 10-20% a portion are adenosquamous, I think a fairly low portion of them...

and then taking into account age as well, I am thinking this is pretty rare.

I cannot find many support groups for younger women in my situation with the same type. Many of them have squamous cells and a few have adenocarcinoma. I haven't met anyone yet with my type. And I have read there are some differences in survival rates, etc. from one to the other so they cannot completely relate with me.
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From the National Cancer Institute Seer database, incidence rates are ~12/100,000 ages 20-49, and 15/100,000 for age > 50. I can't find it broken down in smaller age increments. Average age is about 50. I have had a number of twenty year olds over the years, but that is certainly much less common than seeing a 40-50 year old with this problem. I would have to say you are on the rarer end of the spectrum.

Blessings  (+ info)

what does this diagnosis mean? METASTATIC ADENOSQUAMOUS CARCINOMA?


Microscopic description of 2 specimen taken from my mother's neck: Tissue sections of specimen A show a malignant tumor of an intimate mixture of squamous and glandular patterns replacing lymphoid tissue. the tumor shows only occasional gland formations with cells with hyperchromatic nuclei and eosinophilic to clear cytoplasm. Solid sheets of malignant squamous cells are prominent; the tumor cells have large round vesicular nuclei with prominent nucleoli and abundant cytoplasm. The stroma shows necrotic areas, fibrosis and hemorrhages. Specimen B is also of malignant tumor tissue composed of malignant giant cells and large pleomorphic cells with giant single to multiple nuclei. A stroma of mixed leucocytic infiltrates noted.
So far, the doctors are clueless where the origin of this tumor is and somehow they didn't (or won't) explain the details of this biopsy. Also they have not asked for further tests to be done so we can know more. Can someone please help us understand this?
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It is unusual and disappointing the doctor who ordered this biopsy would hand over a report with no explanation. It is part of their job. It means she has cancer that has both glandular and squamous elements and it has nearly completely taken over one of her lymph nodes. Everything else is just explaining what the cells look like. This cancer has spread to her neck from somewhere else not mentioned.

It is also unusual for further tests to not be done. There should be further tests on the specimen and on the patient. It is more difficult to treat an unknown primary so every effort should be made to determine the primary site. However, there are times it is just not possible and they have to work with what they do know.

If the doctor is not explaining and further tests are not being done I suggest you get all of her records together and get a second opinion.  (+ info)

What is a carcinoma and how is it taken out?


A relative of mine has a carcinoma on his liver that needs to be removed. Doctors say it's gonna be hard to remove it, but so far the prognosis is good.

Also, how does it differ from a regular tumor and / or regular cancer?
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A carcinoma "IS" a regular type of cancer involving the liver.
I have seen hundreds of them.
It depends if it is a primary or a metastatic carcinoma in (not on) the liver.
What is the biopsy histology ? You tell us nothing useful to diagnose this case.
There is no "good" prognosis with a carcinoma involving the liver.
If you really want to know what is happening,
go with your relative when he sees his doctors.
Then study on the internet.
It takes 13 years of higher education to be a cancer specialist.  (+ info)

Why is basal cell carcinoma the least invasive of all cancers?


Basal Cell Carcinoma (BCC) can develop into large unsightly skin tumors but the cells rarely metasize or spread to distant sites like malignant melanoma, lung cancer, colon cancer etc.
Is it that only certain genes are involved in BCC which mean they fail to become completely immature like other tumor cells, or is it they are more liable to be attacked by the immune system? Any other ideas?
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Simon - Great question! Sorry that the answer is not yet known. Most cancer research efforts have been directed towards the malignant tumors which rapidly invade the blood vessels and lymph channels making their spread easily, but not malignant basal cells of basal cell carcinoma (BCC). It may be genetic, as you mention, or the BCC cells may lack certain genes and/or enzymes which would allow the cells to survive in other body locations. It is NOT likely to be related to the immune system as microscopic examination of BCC lesions do not show the tissue changes of immune-type cells adjacent to or invading the BCC as they do with other tumors. Hence, the BCC spreads by ever-widening direct growth from the primary tumor without metastases but able to invade the toughest of nearby tissues, even bone. Might you be interested in such a research career in dermatopathology?  (+ info)

How long does someone with stage 4 Renal cell carcinoma have?


My grandfather, 83, has stage 4 renal cell carcinoma. The cancer has spread to his lungs (several tumors on lungs), bladder, gall bladder, and the doctor said he could feel tumors all over. I just want a realistic outlook for his life expectancy. He will be receiving immunotherapy in a few weeks but his general practice doctor seemed to think he had weeks to a few months to live. His oncologist didn't give him a time frame. I just want to know what he is looking at. He already is having trouble breathing.
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No one knows.My wife has stage IV renal cell carcinoma and no one thought she would make it one year.It been a tough road, but shes still here 5 years 5 months latter.  (+ info)

What is small cell carcinoma, and why is edema in the upper body a serious complication.?


A family member has small cell carcinoma being treated with chemotherapy in the lung/thoracic area, and recently has developed edema in the arms and chest (not sure specifics of where in the chest the edema is). What is this type of cancer and what is the concern with the edema when it develops secondary to the cancer? Thank You.
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oedema of the upper body is due to blockage (partial) of the superior vena cava (the main vein which drains the part of the body above the level of the heart). this is due to infiltration of the vein by the malignant tumour. its a bad prognostic factor.

as for small cell carcinoma, it is a highly malignant tumour of the lungs, and spreads rapidly. it also produces certain hormones that mimic hormonal imbalance states (paraneoplastic syndrome).

u can type in "small cell carcinoma" on wikiepedia and check the other details for urself.  (+ info)

What is the ribbon color for thymus cancer, more specifically thymic carcinoma?


My mom was diagnosed with having a thymic carcinoma and i want to know what color ribbon that is associated with.
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its teal  (+ info)

What are some treatments for Basal Cell Carcinoma?


I think i have Basal Cell Carcinoma, And I'm going to the clinic Thursday, and i was wondering what i have to look forward to.. Like what they'll do to treat it.
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Basal Cell Carcinoma is a type of skin cancer. It is typically a very slow growing, non-invasive cancer and is treated very effectivly by excision. If the doctor believes the lesion to be suspicious of BCC, they will likely schedule a biopsy to confirm this, and then completely remove it by cutting it out and placing a couple of stiches on the wound.  (+ info)

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