FAQ - hypereosinophilic syndrome
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what do u know abt hypereosinophilic syndrome?

Hypereosinophilic syndrome rarely occurs in children. It causes excessive numbers of eosinophils (a type of white blood cell) to accumulate in the blood. Elevated levels of eosinophils can damage organs throughout the body. The origin of the syndrome is unknown.

Treatment for hypereosinophilic syndrome involves steroids and other medications to stop the overproduction of eosinophils.
White blood cell disorders can cause several conditions, including:

Frequent infections
Mouth sores
A thorough diagnosis requires blood tests to identify the white blood cell condition. If white blood cell count abnormalities are found, a Mayo Clinic pediatric hematologist will work closely with highly trained laboratory specialists to determine the cause. A sample of bone marrow may be taken. This biopsy involves carefully inserting a thin needle into the bone to collect a sample of bone marrow tissue and then examining the cells under a microscope.
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What is hypereosinophilic syndrome? Hypereosinophilic syndrome (HES) is a group of conditions where you have too many eosinophils (e-o-SIN-o-fils) in your blood. Eosinophils are white blood cells that fight infection with parasites (small living creatures). They are also present with certain allergic diseases, such as asthma. They slightly increase in number during these conditions or when you take certain drugs or medicines. With HES, the increased numbers of eosinophils stay in your body for too long and cause damage to your organs. The eosinophils cause damage from swelling inside the organs of your body. This happens most often in the brain, heart, lungs, and skin. You may also have swelling of your kidneys, intestines, liver, and spleen.

What causes hypereosinophilic syndrome? The exact cause of HES is not known. Problems in your immune system may cause HES. The immune system is your body's defense system against infections and diseases. A chemical imbalance in your body or damage to the cells that make eosinophils may cause HES.

What are the signs and symptoms of hypereosinophilic syndrome? You may have any of the following:

Chest pain.

Fever, feeling very weak, tiring very easily, or weight loss.

Redness, swelling, itching, or flaking of your skin.

Weakness or numbness in parts of your body.

Throwing up, having watery stools, or pain in your abdomen (stomach).

Trouble breathing or having a dry cough for a long time.

How is hypereosinophilic syndrome diagnosed? Your caregiver will ask you about your medical, travel, and drug history. Other medical conditions may cause you to have the same symptoms as HES. Your caregiver will check if you have other conditions that cause eosinophils to increase. He will do a physical exam on you. You may also have other tests to check your organs for damage. You may have any of the following:

Blood tests: You may need blood taken for tests. The blood can be taken from a blood vessel in your hand, arm, or the bend in your elbow. It is tested to see how your body is doing. It can give your caregivers more information about your health condition. You may need to have blood drawn more than once.

Bone marrow biopsy: This is a procedure where a sample of bone marrow is removed and sent to a lab for tests. Bone marrow is the soft, spongy tissue inside the bone. The skin over your upper hipbone is first cleaned. Caregivers put numbing medicine into your skin so you will have little pain. You caregiver may also give you medicine for anxiety and pain through an intravenous (IV) tube in your vein (blood vessel). A bandage is put on the biopsy area after the tissue sample is taken. Ask your caregiver for more information about bone marrow biopsy.


This test is also called an echo. It is a type of ultrasound, using sound waves to show pictures of the size and shape of your heart. An echo also looks at how your heart moves when it is beating. These pictures are seen on a TV-like screen. This test can tell how well your heart is pumping. An echo can also find problems, such as a blood clot in your heart or thickening of your heart muscle. Ask your caregiver for more information about transthoracic echocardiogram.

Stool test: This is a test where a sample of your stool is examined to see if you have parasites.

Chest x-ray: This is a picture of your lungs and heart. Caregivers use it to see how your lungs and heart are doing. Caregivers may use the x-ray to look for signs of infection like pneumonia, or to look for collapsed lungs. Chest x-rays may show tumors, broken ribs, or fluid around the heart and lungs.

How is hypereosinophilic syndrome treated? You may have any of the following:


Immune system and chemotherapy medicines: These medicines may slow the making of eosinophils to decrease the number of eosinophils in your blood.

Steroid medicine: This medicine decreases inflammation (redness), pain, and swelling. Inflammation may be found in organs damaged by eosinophils. Steroids may also decrease the number of eosinophils and prevent further damage. This medicine can be very helpful for your condition, but it has side effects. Be sure you understand why you need steroids. Do not stop taking this medicine without your caregivers OK. Stopping on your own can cause problems.

Bone marrow transplant: This is a procedure where you receive healthy bone marrow from a donor. Bone marrow is the tissue where blood cells, including eosinophils, are made. You will receive medicine to weaken your own bone marrow before receiving the donor bone marrow. Your caregiver may use this procedure if all other medicines do not decrease your symptoms. Ask your caregiver for more information about bone marrow transplant.

Where can I find support and more information? HES may be a life-changing condition for you and your family. Accepting that you have HES may be hard. You and those close to you may feel sad, angry, or frightened. These are normal feelings. Talk to your caregivers, family, or friends about your feelings. Contact the following for more information:

American Partnership for Eosinophilic Disorders
3419 Whispering Way Drive
Richmond, TX 77469
Phone: 1-713-498-8216
Web Address: http://www.apfed.org


What is the name of the syndrome that the person may appear to have facial characteristics of down's syndrome?

I previously watched a documentary about sufferers of a syndrome whose facial features appeared to be down's syndrome but it wasn't down's syndrome. The grow to be quite large adults and have special needs. Does anyone know the name of this condition?

Klinefelter syndrome  (+ info)

Are there different types of Down syndrome and what areas of the body does Down syndrome affect? ?

Also, are there any significant statistics related to Down syndrome? Has Down syndrome received any recent attention from the media? Are there any famous people that have Down syndrome.
Answer as many of the above questions as possible.

There are three types of Down syndrome, garden variety Trisomy 21, mosaicism and translocation.

Read more at:

Welcoming Babies with Down Syndrome (English, Spanish, French)

There is a slide show that also incorporates videos of the featured 'More Alike than Different' cast at the National Down Syndrome Congress website:


And great information at the National Down Syndrome Society website:
Down Syndrome Fact Sheet

You might also enjoy

Margaret's Guide to Down Syndrome

For bios of actors with Down syndrome, see:

Down Syndrome and the Acting Gene


DS in Arts and Media


Michael Johnson


Sujeet Desai

Down Syndrome Links at the Family Village website

Check out this recent New York Times article:

The DNA Age: Prenatal Test Puts Down Syndrome in Hard Focus

Have fun with your research!
  (+ info)

What is so bad about having down syndrome?

I think people are a lot colder than they want you to believe. Too many pregnancies prediagnosed with down syndrome are terminated! Doctors tell people that their kid will be like some animal and people believe them. I've met my share of people with down syndrome, and they all seem pretty human to me. On top of that, they were all decent folks, which is a lot more than I can say for the general population. And how does knowing that unborn children are purged because of down syndrome affect those who were born and have down syndrome?

WOW!! I'm so glad that there are other people who's lives have been touched as mine has. See when I was 28 I gave birth to twin girls and one of them was born with Mosaic down syndrome. Of course, I didn't know much about it til now....and yes I was shocked. They are 14 months old now, and such a blessing as well as my two boys. My daughter is about 4 months behind in her milestones, but she is always so happy! Out of all my kids she is the easiest to handle.

It's always nice to have other people, who see that they are more alike, then different from the rest of us.  (+ info)

What is the syndrome called when you cannot feel physical pain?

I remember watching a show a long time ago, and this one little girl was born with a syndrome where she could never feel pain. If she fell on the floor and cut her knee, she wouldn't cry, whereas most children would.

What is this called? Is it a syndrome? Is it a medical condition? I just want to know what it's called, and I can do the research on it.

It is for a story I am writing but I don't entirely know what it is.

It's called "congenital insensitivity to pain"  (+ info)

What syndrome would someone have that the doctor would need to put them on bloodthinners?

My sister is 18 and just moved out here from MN to go to school. She has had many medical problems and been to several doctors. She recently told me that the doctor said there was something wrong with her blood and she needs to be put on blood thinners for the rest of her life. What syndrome could this be?

There are several, but the first that comes to mind is Factor-V (five).  (+ info)

What is the syndrome where boys usually grow more than average?

I think it is Jacobs syndome.. XYY syndrome.. but wikipedia says that is only a little more than average. what is the only where they get really big ?

Yes it is called gigantism. It is caused by a tumour or either a chromosome disorder. Another thing that causes gigantism is the inability to inhib the GH (growth hormone) when it is produced. This is why the people who have it get very TALL.  (+ info)

Adrenal Fatigue Syndrome where in Philippines can i get a help?


I need some help with Adrenal Fatigue Syndrome. My mom thinks she has this Adrenal Fatigue Syndrome and needs a doctor to confirm this. Where in the Philippines can I find help or what type of doctor she should see? Do you know one? Please advice


  (+ info)

What are the chances of my children having Tourette syndrome?

Im planning to have a family in the future. Both of us dont have this syndrome. However, her mother does from her grandpa. Only blinking eyes. What are the chances of passing this on? Also, if it is passed on would it only be blinking eyes or could it be other symptoms of this same syndrome?

Were you aware that there is a National Tourette Syndrome Association? I would suggest contacting them and asking these questions.  (+ info)

What are the complications if a person has nephrotic syndrome and gets cancer?

My wife has nephrotic syndrome (a kidney disease) and the doctor, due to recent blood test findings, believes she has cancer. Are there any complications that could come from having the syndrome and having to now fight cancer.

This is a dillematic situation - so far that I can say. Kidney cancer is a rare type of cancer. To treat cancer, doctor would suggest chemo/radiation/surgery... depends on the stage.

Does the disease affect both kidneys or only one? All chemo drugs are very strong, I'm afraid cannot be applied to your wife, given that her kidney is the one who has problem.

However, I believe that your doctor will know the best of her condition, hence can determine best treatment (maybe kidney transplantation?). '

In the mean time, it's important that your wife change to a healthy lifestyle, healthy food and enough rest. Good luck.  (+ info)

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