FAQ - mitochondrial diseases
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Mitochondrial Myopathy and Mitochondrial diseases in general?

Can somebody please answer the follow questions concerning MD (mitochondrial diseases)?

Is the disorder on the rise or decline in North America? The world?

If you find any information, please copy down the website (or books with author, title, page number, publication, year of publication wrote down)


start from here:
http://rds.yahoo.com/_ylt=A0geu.m2pwJHskABMzNXNyoA/SIG=142e7tv8n/EXP=1191442742/**http%3a//search.yahoo.com/search%3fei=UTF-8%26fr=ks-ans%26p=human%2bmitochondrial%2bdiseases%26rs=0%26fr2=rs-top  (+ info)

What are some of the causes of non genetic or "acquired" mitochondrial disease?

I have been told that there are cases of mitochondrial disease that are non-genetic and that other diseases, environmental factors, etc. can cause mitochondrial dysfunction. What are some of the more common factors?

Heavy metal toxicities (lead, mercury, arsenic, etc.) are probably the most common environmental cause.

Chemical toxicities may also have the potential to damage mitochondria.

Additionally, micronutrient deficiencies (e.g. iron deficiency, etc.) can damage mitochrondria.

Lastly, any excessive source of oxidatived stress or deficiency of antioxidant potential can damage mitochondria.  (+ info)

How is "non-genetic" Mitochondrial Disease determined to be, in fact, non-genetic.?

Short of a crystal ball, without any family history to rely on, how would a clinician or researcher arrive at a "non-genetic" diagnosis?
Other than a "non-professional" guess, is there anything in the area of testing that might lead to such a diagnosis?

This is a guess. If it's non genetic it means it doesn't run the person's family or there are no known carriers in the family.  (+ info)

mitochondrial disease - why can people who have this, only excersise for short periods of time?

i dont understand. i know that people with mitochondrial disease have mitochondria that does not function properly, but
why are they unable to excersise for very long?

To understand the answer, you need to know what Mitochondria do. Here is the short, simplified answer.
- Mitochondria are the powerhouse of your cells. ATP (which is what your cells and body use for energy) is made in the mitochondria. Normally, mitochondria work constantly, renueing ATP as long as you keep bringing in new oxygen, which allows you to keep working out and moving. BUT when your mitochondria are abnormal, they don't make the energy or ATP that the cells need to function, when these cells can't get energy, lactic acid builds up, which causes muscle fatigue and aches... The oxygen that a normal person can breath, doesn't work as well in people with mitochondrial disorders, so the cell has to default to LACTIC ACID production to make energy. Well, in order to clear out the lactic acid, you need to rest.

Hope this helps  (+ info)

How do you file for SSDI with a mitochondrial myopathy condition?

I have been diagnosed with a mitochondrial myopathy and would like to know how to file for social security.

  (+ info)

Any professional athletes that have a mitochondrial myopathy disorder?

Is there any other professional athelet (other than Rocco Baldelli) that have any kind of mitochondrial myopathy disorder?

Is there any information on them and how they deal with it?

Quit taking statin drugs, do take CoQ10 and selenium.  (+ info)

What diseases would have the symptom of coughing up blood or blood in the phlegm?

This is not a symptom of my own so please don't tell me to go to the doctor, it is for a piece of work I have to do for College.

If you could tell me the name of a disease/ diseases that cause this, preferably not consumption or TB, a little about it and other symptoms it would be a massive help!
If you could also include treatment options and how serious a disease it is that would also be fantastic!

Hope you can help! Thanks!

First: spitting up blood is clinically known as: HEMOPTYSIS (bloody sputum, spit)
Yes, pneumonia is the most likely, but......
The following is from my medical e-book (I'm a nursing student)

"Blood in the sputum (hemoptysis) is most often seen in clients with chronic bronchitis or lung cancer. Clients with tuberculosis, pulmonary infarction, bronchial adenoma, or lung abscess may have grossly bloody sputum."
Also the end stage of cycstic fibrosis will present with hemoptysis.

a biggie in the hospital is:
A pulmonary embolism (PE) is a collection of particulate matter (solids, liquids, or gaseous substances) that enters venous circulation and lodges in the pulmonary vessels. Large emboli obstruct pulmonary blood flow, leading to decreased systemic oxygenation, pulmonary tissue hypoxia, and potential death. Any substance can cause an embolism, but a blood clot is the most common.

Pulmonary embolism is the most common acute pulmonary disease (90%) among hospitalized clients. In most people with PE, a blood clot from a deep vein thrombosis (DVT) breaks loose from one of the veins in the legs or the pelvis. The thrombus breaks off, travels through the vena cava and right side of the heart, and then lodges in a smaller blood vessel in the lung. Platelets collect with the embolus, triggering the release of substances that cause blood vessel constriction. Widespread pulmonary vessel constriction and pulmonary hypertension impair gas exchange. Deoxygenated blood shunts into the arterial circulation, causing hypoxemia. About 12% of clients with PE do not have hypoxemia.

Pulmonary embolism affects at least 500,000 people a year in the United States, about 10% of whom die. Many die within 1 hour of the onset of symptoms or before the diagnosis has even been suspected.

For clients with a known risk for PE, small doses of prophylactic subcutaneous heparin may be prescribed every 8 to 12 hours. Heparin prevents excessive coagulation in clients immobilized for a prolonged period, after trauma or surgery, or when restricted to bedrest. Occasionally, a drug to reduce platelet aggregation, such as clopidogrel (Plavix), is used in place of heparin.

A smaller one that popped up in the book:
Goodpasture's syndrome is an autoimmune disorder in which autoantibodies are made against the glomerular basement membrane and neutrophils. The two organs with the most damage are the lungs and the kidney. Lung damage is manifested as pulmonary hemorrhage. Kidney damage manifests as glomerulonephritis that may rapidly progress to complete renal failure (see Chapters 74 and 75). Unlike other autoimmune disorders, Goodpasture's syndrome occurs most often in adolescent or young adult men. The exact cause or triggering agent is unknown.

Goodpasture's syndrome usually is not diagnosed until serious lung and/or kidney problems are present. Manifestations include shortness of breath, hemoptysis (bloody sputum), decreased urine output, weight gain, generalized nondependent edema, hypertension, and tachycardia. Chest x-rays show areas of consolidation. The most common cause of death is uremia as a result of renal failure.

Spontaneous resolution of Goodpasture's syndrome has occurred but is rare. Interventions focus on reducing the immune-mediated damage and performing some type of renal supportive therapy.

  (+ info)

What diseases can you get from cutting yourself with a rusty knife?

This is a question from a growing nurse. I've always wondered if you really can get a disease from a rusty knife or any rust and what kind of diseases you can get.

staph aureus and staph epidermidis are commonly found on the skin and are responsible for
most infected wounds. methicillin resistant staph aureus (MRSA) is becoming a serious
problem. tetanus (clostridium tetani) is also a possibility but is usually not a problem with superficial
cuts that bleed a lot. infected wounds not treated properly can become gangrenous (clostridium
perfringens). clostridium bacteria are anaerobic which means that require a lack of oxygen to
grow. poor circulation or elevating an infected foot may lead to gangrene due to the lack of oxygen
in the infected area. if a person touches the cut with unclean hands, e. coli could infect the wound.  (+ info)

What causes mitochondrial disease?

Can you give me a site for what causes Mitochondrial disease? If you know someone with that disease can you share their (or your) story please. Thank you!

There are several causes of a mitochondrial dysfunction.Genetics, oxidative stress,iron overload-Who is suffering from this disease?  (+ info)

How were these diseases prevented or cured in the 1600 to early 1700s?


How were some of these diseases dealt with in the 1600s? If there was no cure or anything to prevent the diseases to happen can you explain why and what resulted in these situations? Thanks!

Inoculation was sometimes used to prevent smallpox but basically either you lived or you died. Most survived chickenpox & measles but there were those who died or were left scarred or with damage to the vision or nervous system. Malaria was a disease of the tropics and is found in parts of Africa, Asia, the Middle East, Central and South America, Hispaniola, and Oceania. Mostly people died.

The 1600s were in the 17th century & the 1700s were in the 18th century. Do some online research.  (+ info)

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