FAQ - muscular atrophy
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How many days of inactivity does it take for me to start atrophy on my muscles and loss of metabolism?

14 years old

150 pounds (varies from day to day, anywhere from 147-155)

6' 0''

Overall in pretty decent shape. Not over-weight, not too skinny, not too weak or extraordinarily muscular

So, how many approximate days would it take for my metabolism to start slowing down, and for atrophy to begin taking place with my muscles?

Not sure of the metabolism part but i know after 3 days you will notice you muscles starting to shrink.  (+ info)

spinal muscular atrophy?

I am definitely not asking for medical advice just some naturally suggestion. Do anyone know of any natural food or vitamins that you can take to help redevelop your muscle if you have spinal muscular atrophy and it is not the same as taking proteins because although it is call spinal muscular atrophy it is the wasting of the nerve of the muscle and if anyone out there know of any type of natural remedy I sure would really appreciate your help. They keep saying they are looking for a cure but it is taking they a little too long. Please Help

Spinal muscular atrophy (SMA) is a genetic disease that attacks nerve cells, called motor neurons, in your spinal cord. These neurons communicate with your voluntary muscles - the ones you can control, like in your arms and legs. As you lose the neurons, your muscles weaken. This can affect walking, crawling, breathing, swallowing and head and neck control.

SMA runs in families. Parents usually have no symptoms, but still carry the gene. Genetic counseling is important if the disease runs in your family.

There are many types of SMA, and some of them are fatal. Life expectancy depends on the type you have and how it affects your breathing. There is no cure. Medicines and physical therapy help treat symptoms.  (+ info)

Does Or Can Agent Orange cause Muscular Dystrophy, Is There Any Research On This?

I suffer with muscular dystrophy which I contracted while serving in Viet Nam from 8-14-68 to 9-3-69. I served in the 3rd Mar Div, Delta 1/4, D Company. I was not born with this disease, carry the gene nor is it dormant or autoimmune. Plus, no one in my family has it either. Doctors at Muscular Dystrophy Association have proven this through a fsh test, and have save that my condition is due to exposure to agent orange. I have been trying to get service connection for my condition ever since 1970. In the CFR of Title 38, subsection 3.307. it has listed Atrophy-Progressive muscular. Now, wouldn't muscular dystrophy fall into this category also?

I thank you in advance for your answer.

There are some things you do not specify in your question.
One were you actually exposed to agent orange and is there proof?
If you have no proof of being exposed I would think that your chances of getting anything out of the government highly unlikely.
Two which Muscular Dystrophy do you have?
There are 30 or so Dystrophies some of those Dystrophies also have sub categories. In many of these Dystrophies they can occur spontaneously. Are not from birth, no family history and some they do not know the gene that causes it. There are genetic tests for some Dystophies but not all.
Third you state your doctors have proven you dont have this from birth, carry the gene, ETC... through an FSH TEST?
An FSH Test does not give any diffinitive diagnosis, other than you dont have that particular Dystrophy. Being Facioscapulohumeral Dystrophy. This does not rule out other Dystrophies.
When diagnosing a Dystrophy other than those they have a blood test for( most are not detectable by a blood test) It requires alot of tests including Blood tests to rule out the ones that are detectable, EMG, Nerve conduction, MRI, and Muscle biopsies.
So if you would like to provide more information to clarify these points, an answer would be easier to provide.
I can be emailed through my profile page.
Or if you want more information on Dystrophies I suggest doing a search and visiting the various Dystrophy Sites.
My Best Wishes  (+ info)

Spinal Muscular Atrophy support groups?

I lost my little girl May 4th to SMA and I am looking for some kind of support groups where I can talk to other parents who have been through this or are currently going through this. Does anyone know where I can find one?

  (+ info)

Spinal Muscular Atrophy Type 1?

Can someone give me any information on this? What causes it, treatments, (is it always fatal?) really just anything you know?

A (ex) friend from high school's daughter just died from it, and I've never heard of it.
She was only about 6 months old.

I've found this for you on wikipedia http://en.wikipedia.org/wiki/Spinal_muscular_atrophy

It would seem that it's always fatal, and the sooner the symptoms show up, the earlier the patient will die. It is genetic, and has to do with chromosone 5, which contains the survival neutron gene. There's a whole explanation for it on wikepedia.

SMA type I (what your friend's baby had), also known as severe infantile SMA or Werdnig Hoffmann disease, is the most severe, and manifests in the first year of life. This type generally onsets quickly and unexpectedly after birth; babies diagnosed with Type I SMA do not generally live past one year of age. Pneumonia is considered the ultimate cause of death due to deterioration of survival motor neurons; motor neuron death causes insufficient functioning of the major bodily organ systems, particularly respiratory (e.g. breathing, ridding of pooled secretions inside lungs).


I'm sorry for your friend's loss.  (+ info)

anyone know anything about spinal muscular atrophy?

Spinal Muscular Atrophy (SMA) is a term applied to a number of different disorders, all having in common a genetic cause and the manifestation of weakness due to loss of the motor neurons of the spinal cord and brainstem.

Infantile SMA is the most severe form. Some of the symptoms include:

muscle weakness
poor muscle tone
weak cry
limpness or a tendency to flop
difficulty sucking or swallowing
accumulation of secretions in the lungs or throat
the legs tend to be weaker than the arms
feeding difficulties
increased susceptibility to respiratory tract infections
developmental milestones, such as lifting the head or sitting up, can't be reached.
In general, the earlier the symptoms appear, the shorter the life span. The onset is sudden and dramatic. Once symptoms appear the motor neuron cells quickly deteriorate shortly after. The disease can be fatal and there is no cure for SMA yet known. The major management issue in Type 1 SMA is the prevention and early treatment of respiratory infections; pneumonia is the cause of death in the majority of the cases. Infants with Type 1 SMA have a life expectancy of less than two years, however, some grow to be adults. Intellectual and later, sexual functions, are unaffected by SMA.

[edit] Diagnosis
In order to be diagnosed with Spinal muscular atrophy, symptoms need to be present. In most cases a diagnosis can be made by the SMN gene test, which determines whether there is at least one copy of the SMN1 gene by looking for its unique sequences (that distinguish it from the almost identical SMN2) in exons 7 and 8. In some cases, when the SMN gene test is not possible or does not show any abnormality, other tests such as an EMG electromyography (EMG) or muscle biopsy may be indicated.

[edit] Cause
The region of chromosome 5 that contains the SMN (survival motor neuron) gene has a large duplication. A large sequence that contains several genes occurs twice in adjacent segments. There are thus two copies of the gene, SMN1 and SMN2. The SMN2 gene has an additional mutation that makes it less efficient at making protein, though it does so in a low level. SMA is caused by loss of the SMN1 gene from both chromosomes. The severity of SMA, ranging from SMA 1 to SMA 3, is partly related to how well the remaining SMN 2 genes can make up for the loss of SMN 1. Often there are additional copies of SMN2, and an increasing number of SMN2 copies causes less severe disease.

All forms of SMN-associated SMA have a combined incidence of about 1 in 6,000. SMA is the most common cause of genetically determined neonatal death. The gene frequency is thus around 1:80, and approximately one in 40 persons are carriers. There are no known health consequences of being a carrier, and the only way one might know to consider the possibility is if a relative is affected.

[edit] Types

[edit] Caused by mutation of the SMN gene
The most common form of SMA is caused by mutation of the SMN gene, and manifests over a wide range of severity affecting infants through adults. This spectrum has been divided arbitrarily into four groups by the level of weakness.

Infantile SMA - Type 1 or Werdnig-Hoffmann disease (generally 0-6 months). SMA type 1, also known as severe infantile SMA or Werdnig Hoffmann disease, is the most severe, and manifests in the first year of life with the inability to ever maintain an independent sitting position.
Intermediate SMA - Type 2 (generally 7-18 months). Type 2 SMA, or intermediate SMA, describes those children who are never able to stand and walk, but who are able to maintain a sitting position at least some time in their life. The onset of weakness is usually recognized some time between 6 and 18 months.
Juvenile SMA - Type 3 or Kugelberg-Welander disease (generally >18 months). SMA type 3 describes those who are able to walk at some time.
Adult SMA - Type 4. Weakness usually begins in late adolesceence in tongue, hands, or feet then progresses to other areas of the body. Course of disease is much slower and has little or no impact on life expectancy.

Other forms of SMA
Other forms of spinal muscular atrophy are caused by mutation of other genes, some known and others not yet defined. All forms of SMA have in common weakness caused by denervation, that is, the muscle atrophies because it has lost the signal to contract due to loss of the innervating nerve. Spinal muscular atrophy only affects motor nerves. Heritable disorders that cause both weakness due to motor denervation along with sensory impairment due to sensory denervation are known by the inclusive label Charcot-Marie-Tooth or Hereditary Motor Sensory Neuropathy. The term spinal muscular atrophy thus refers to atrophy of muscles due to loss of motor neurons within the spinal cord.

The course of SMA is directly related to the severity of weakness. Infants with the severe form of SMA frequently succumb to respiratory disease due to weakness of the muscles that support breathing. Children with milder forms of SMA naturally live much longer although they may need extensive medical support, especially those at the more severe end of the spectrum.

Although gene replacement strategies are being tested in animals, current treatment for SMA consists of prevention and management of the secondary effect of chronic motor unit loss. It is likely that gene replacement for SMA will require many more years of investigation before it can be applied to humans. Due to molecular biology, there is a better understanding of SMA. The disease is caused by deficiency of SMN (survival motor neuron) protein, and therefore approaches to developing treatment include searching for drugs that increase SMN levels, enhance residual SMN function, or compensate for its loss.

Much can be done for SMA patients in terms of medical and in particular respiratory, nutritional and rehabilitation care. However, there is currently no drug known to alter the course of SMA. Significant progress has been made in preclincial research towards an effective treatment. Several drugs have been identified in laboratory experiments that hold promise for patients. To evaluate if these drugs benefit SMA patients, clinical trials are needed. In a clinical trial a new medication is tested while the patients are carefully monitored for their safety and for any possible drug effects, positive or negative.

Some drugs under clinical investigation for the treatment of SMA:

Valproic acid
Riluzole  (+ info)

Spinal Bulbar Muscular Atrophy?

what is it? what is its cause? whats the disease process and what does it do to cause a problem? what do they do to diagnose it? support group information?.....please help

Spinal Bulbar Muscular Atrophy, or Kennedy's disease for short, is a genetic defect that causes muscle cramps and progressive weakness due to degeneration of nerves in your brain spinal cord. Symptoms usually begin appearing between the ages of 30 and 50

Only men are affected by it, with Kennedy's disease in women extremely rare. They test your DNA in order to find the genetic defect that causes it.

A good online support group can be found at
http://www.kennedysdisease.org/index.html  (+ info)

My nephew has spinal muscular atrophy...?

Does anyone know a good place with trained medical dogs that will alert to his conditions troubles? Thank you so much!

Check out this website

http://www.caninesforkids.org/  (+ info)

anyone kno anything about spinal muscular atrophy?????

i juss wanted to kno if u have SMA wat r the risks of having a child i really need to kno this info if u can plzz help me out i would greatly appreciate it thank u so so much.

p.s its type 2

This would depend on family history and ethnicity of person you are having a child with. If you are considering pregnancy and have SMA, I recommend that you request referral to a genetic counselor for a preconception counseling visit to discuss risks associated with your condition and pregnancy.  (+ info)

Spinal Muscular Atrophy (SMA)?

can you please explain:
how the gentic defect occurs.
i know that it is an autosomal ressisive but i dont know what that means.
it says in wikipedia: that it means that we have a defect in both genes in both chromosomes?
do they mean mom chromosom and dad's
the chromosome that is composed of two chromatids( one from mom and the other form dad? is that it?
plz i need ya'r help..



Genetics are complicated. But if two parents both carry a recessive gene. You would get :

1/4 chance the child is normal
2/4 chance the child is a carrier-has the recessive gene
1/4 chance the child has the trait or the disease

There are many recessive traits and diseases-blue eyes, muscular dystrophy's and many more.

There is genetic counseling if you are concerned about having a child with SMA.



There are 3 child type of SMA and one adult onset. I have treated children with all three types as a physical therapist. Please give some more information so I can give you more of an answer.
  (+ info)

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