FAQ - polyarteritis nodosa
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Who is doing the most research regarding Vasculitis and Polyarteritis Nodosa?


What medical centers, pharma. companies, universities, etc. are leading research on forms of vasculitis including polyarteritis nodosa?
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John Hopkins has a vasculitis center  (+ info)

Is polyarteritis nodosa an autoimmune disease?


No. Polyarteritis nodosa is the inflammation of the arterial wall of the blood vessels.  (+ info)

Whats the treatment of polyateritis nodosa?


When my son fell sick he got so many types of drugs which could not cure him. May be I can compare with yours and see. Thank you.
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Treatment usually consists of large doses of corticosteroids to reduce inflammation along with immunosuppressant drugs to counter the body's autoimmune response. Treatment usually lasts for at least one year to eighteen months, with medication doses gradually being reduced over the period as long as the inflammation remains under control. Full recoveries have been recorded with some patients experiencing no relapses. Past studies have shown that the 5 year survival rate for PAN with no treatment is 13%, with steroids alone 50%, and with steroids and immunosuppressants 80%+, but survival rates are increasing as treatment regimes become better focussed.

Base treatment is fairly well established, but even so full scientific consensus is not 100% agreed upon. However, recent evidence points to a requirement in the first instance of an aggressive treatment with cortico-steroids (daily 500mg IV pulses of methylpredisolone for one to three days) followed by prednisolone at 1mg/kg bodyweight per day for 4 to 6 weeks (orally) after which the dose can be tapered progressively. Concurrent immunosuppressants are compulsory comprising 125mg daily Cyclophosphamide (orally). Current wisdom also suggests benefits with pulses of cyclophosphamide at 0.5. to 0.6gr/sqm at days 0, 15, 30 and then every 4 weeks for 6 pulses. Again the cyclophosphamide can be progressively tapered and a maintenance treatment with Azathioprine is indicated at 2mg/kg bodyweight per day. Imuran is often used as a replacement therapy for Cyclophosphamide as well.  (+ info)

Whats the cause of this desease called "Polyteritis Nodosa"?


Last August I lost a 14 year boy who suffered from a disease called Polyteritis Nodosa. It took time for the doctors to discover it. They took XRAYS,SCAN until discovered he has an infection though at first they were treating Malaria. After his leg swell then they discovered that he has an infection which is not common here in Africa. And we wonder where could have the boy got the disease. Doctors said it is common in Japan and Canada. But this boy has never travelled to oversease countries. So they tried their best to treat him but my son died. Thank you.
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Hi,

Sorry to hear about your son.

The disease is called polyarteritis nodosa. It's a disease that causes inflammation in blood vessels which leads to their destruction.

The disease involves many organs in the body. It can present as a self limited disease that has only skin lesions or as a severe disease that involves many organs which leads to their disfunction, and to death.

Nothing is known at the moment about the genetics of the disease. In the USA it occurs in 9-17 out of 1,000,000 people. It usually affects people of all ages and is much more common in males than females.

The causes of the disease are unclear as of today. There is evidence that maybe the immunologic system in the body is responsible, because when checking for values of factors in the blood that usually go up in diseases that have an immune cause, these factors go up in this disease as well.

These include:
1. antibodies of the type endothelial COH
2. antibodies that are common in other diseases of blood vessels, called ANCA
3. There is also a connection with infection from Hepatitis virus (that causes a liver disease usually). In 30% of people with the disease the virus was found in the blood. It's possible that the body's response to the virus causes the disease.  (+ info)

Polyarteritis Nodasa Emergency?


Respected Gentlemen

First sorry my english. I have a nephew that has the disease Knotted Polyarteritis Nodasa , (that is a rare disease in the blood and of dragged evolution) from child, however with the use of Corticoide he got better.
Some years later, already in the adolescence it returned, but now besides doctors to increase the corticoide dosage, but he has everyday a big fever and doesn´t pass, the corticoide has other side effects that are already appearing, His name is Felipe, that now, adolescent only sleeps, he wakes up everyday with fever and he is falling their hair. Please, I please ask for the kindness: What do make? Who do seek?
Which hospital? ( I live in Brazil) which doctors should seek? You can indicate me knotted Polyarteritis Nodasa in the exterior it´s necessary for us, because we are losing the hopes.
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You should really ask in Yahoo Brazil, because the people on the English Yahoo live in countries like the UK, Australia, and USA. Even if anyone did have suggestions, they wouldn't be close enough for you to go easily.  (+ info)

salpingitis isthmica nodosa?


Anyone ever heard of this condition? Otherwise known as SIN? I've just been diagnosed with it and wanted further information, as well hearing any success stories of pregnancies while having this condition.
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is there a cure for polyarteritis?


There are tratments for Polyarteritis Nodosa, as well as for the many other types of vasculitis (inflammation of the blood vessels.) But, as yet, there is no cure. Many of these illnesses (the Vasculitides) have a relapsing/remitting course. They worsen and improve on their own. The treatments are to prevent severe damage to the arteries during the relapses, so that patients don't experience catostrophic complications like spontaneous rupture of a major artery or blockage of a critical artery (like the carotid or a coronary artery) due to the inflammation or due to scar tissue. Steroids and potent drugs that have been used for cancer are frequently necessary to suppress the inflammation.  (+ info)

When is it time to to stop dialysis?


My mother was diagnosed with polyarteritis nodosa 2 months ago. She is in renal failure in which dialysis will need to continue. She has been in the hospital for a week due to a seizure. She seemed to be getting a little better but then suffered two more seizures in the hospital. Brain function is slow (but may be because of the seizure and/or drugs for the seizure). We thought that we lost her a few days ago, but then she seemed to be coming out of it on Wednesday - then she suffered a seizure again. The MRI stated that there was not stroke or permanent damage. At the meeting with her renal doctor, the PAN is under control - we just need to get her stronger. We are at the delimma - should we stop dialysis or not? Is there any hope for her quality of life? My mom stated to my sister that she did not want to go through dialysis anymore. My brother thinks that we should keep going. What should we do?
My mother was diagnosed with polyarteritis nodosa 2 mths ago. She is in renal failure-dialysis will need to continue. She has been in the hospital for a week due to a seizure. She seemed to be getting a little better but then had another seizure and took a step backwards. Brain function is slow, yes/no answers,not moving much,eyes glazed, high blood pressure. We thought that we lost her a few days ago, but then she seemed to be coming out of it on Wednesday - then she suffered a seizure again. The MRI stated that there was not stroke or permanent damage. At the meeting with her renal doctor, the PAN is under control - we just need to get her stronger. We are at the delimma - should we stop dialysis or not? Is there any hope for her quality of life? My mom stated to my sister that she did not want to go through dialysis anymore. My brother thinks that we should keep going. What should we do?
Presently, my mom is not in a condition to communicate her wishes.
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This is your mother's decision and she should speak to her attending physician about the risks and benifits of such a decision. The PAN may be under control for now but I hope you understand the possible complications that can occur. The renal failure won't stop even with dialysis and continued, uncontrolled seizures are detrimental.

Suppose that both the PAN and seizures are controlled. Okay, now what? Your mother may or may not feel differently about dialysis. Give it time. Persuade her to give it time. She could change her mind.

But whatever her decision...remember that it's her decision to make. Not your brother's. Not your sisters's. Not yours. Support her decision and be her strongest advocate.  (+ info)

Can you help me with my differential?


I have had chronic pain in my back and left leg for 2.5 years. I have had about 10 MRI's, EMGs/NCVs showing only slight decrease in nerve functioning in my ankle. I've had X-rays of my back and leg and blood and urine tests to rule out common causes of nerve pain (lyme disease, SLE, etc.). I have also had a $125,000 spinal angiogram that revealed nothing. Thoracic MRI showed a tiny syrinx from about T2-T12 that my doctors feel is asymptomatic.

I have burning nerve pain in my L5 and S1 from my back to my toes on the left side only. I have muscle stiffness. I can not feel temperature extremes in the affected area. I also have severe GERD, dysphagia, gastritis, stomach cramps and blood in my feces with no findings from colonoscopy.

Recent I've looked in to celiac neuropathy and forms of vasculitis (mainly polyarteritis nodosa). My doctors want me to give up on finding the cause and simply manage the pain. At 21, I don't want to give up. Any input is greatly appreciated.
The location lead my doctors to believe that it was a pinched nerve but with MRI, Xray and EMG they could not find nerve compression anywhere.

Various doctors I have seen (neurosurgeons, neurologist, internist, physiatrist) feel that it is probably Complex Regional Pain Syndrome but they can not confirm. I want to be confident that whatever is causing the pain can not be treated; CRPS essentially means all I can do is manage the pain (which is all I have been able to do thus far but poorly).
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get referred to a good pain management doctor,sounds like you have a pinched sciatic nerve.but reading more of your question it may be something else.good luck!  (+ info)

How do I fix my hair? PLEASE help!?


My hair was cut professionally, and I still had this problem. Recently I cut it myself due to how awful it was. I read that you need to use good scissors, but like I said, the professional did it before and it still got bad.

I have hair that is splitting all the way up the shaft -- everyone says things for keeping it from doing this but what do I do now? I also recognize that I think I have Trichorrhexis nodosa: I have seen it in my hair: (I am Caucasian)
http://adam.about.com/encyclopedia/infectiousdiseases/Trichorrhexis-nodosa.htm

Anyway, I recently cut as much of my hair off as I could (it's very curly and I hate short hair). I don't shampoo anymore, use deep conditioners, and I hardly straighten or blowdry. I used to a LOT in middle school and some in high school but I am halfway through college and have taken good care of my hair for years now. Please someone tell me what to do. Do I need to see my doctor? My hair iembarrasses me everywhere I go. I look like a homeless person.
By the way, I do take vitamins!
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