FAQ - thiamine deficiency
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What is the association between metabolic acidosis caused by high levels of lactate with thiamine deficiency?


Thiamine is a coenzyme for pyruvate dehydrogenase and if severely deficient pyruvate will not be metabolised to acetyl CoA and instead glucose metabolism will be forced down the nonoxidative pathway to form lactate.  (+ info)

can wernicke's encephalopathy thiamine deficiency lesions look like multiple sclerosis lesions?


I was diagnosed with ms 4 years ago after months of not eating and 3 weeks of vomiting I had a bout of double vision. Mri revealed multiple lesions.
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good question, glad you asked. Wernicke's and Ms are completely two different animals. Wernicke is casued by long tern and chronic alocholism. It does not lead to brain lesions per se, but leads to atrophy in the brain and yes you are right, one of the chief reasons is long standing thiamine deficiencey. MS lesions are rare, but can occur. But again, they will appear as atropied areas of the brain as this is an immune disease which casues generalized wasting of the cels. The facto that you are having double vision makes me wonder if you have a carcinoma somethere. Good luck!!  (+ info)

Vitamin B1 (thiamine) deficiency?


Whats a safe but effective dose of Vitamin B1 to take each day to combat possible deficiency?Thanks in advance for any answers
Well I have minor issue with a drooping eyelid which comes and goes - have done some reading up and due to me being a heavy smoker and not always having a great diet I think I could have a vitamin B1 deficency.Also this latest time it happened i had just stopped taking multivitamins (with B1 etc) and have been drinking alcohol a little more than normal....I have multivitamins again now but wasn't sure if 1.5mg would be sufficient to improve my condition.... so its safe to take 100mg per day?
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Actually, if you're deficient on B1, you should take 50-100 mg a few times throughout the day. B1 is water-soluble, so whatever your body doesn't use, it will excrete out within a couple hours.
The other answer is good to ask what the deficiency is from, though... if it's from a shortage in your diet, adding more on a daily basis would cover it, but if it's a medical condition or a prescription that's causing it, you'll need to take care of that or the deficiency would come back. Good luck and I hope I helped!


[edit]: Yes, 100 mg a day is the normal recommendation for optimal health. However, if you're using symptoms as a guideline to say that you're deficient, you'll definitely want to get a blood test to verify (it's a simple and relatively cheap test).
Diagnosing yourself based on symptoms is a great way to narrow down possible problems, but it can be dangerous to run with that diagnosis without verifying because there are many problems and deficiencies that can give similar or the same symptoms. It might be that you aren't getting enough B1 in your diet or it could be some other deficiency or medical condition that's causing those, so I would definitely get it tested to be sure. Good luck!  (+ info)

Beriberi is a deficiency disease caused by inadeequate bodily stores of thiamine (vitamane B 1) it can damage?


A, lifestyle disease
B, Inherited disease
C, genetic disease
D, nutritional disease
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At what rate does thiamine need replacing in the body of a regular drinker?


Just thinking about cutting back my drinking permanently. Been drinking fairly heavily for too many years and the doctors are telling me it's causing me significant vitamin B1 deficiencies.
I'm really curious about how quickly alcohol diminishes the body's supplies of thiamine?
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I have read over your question. It's funny because it make me want to ask you a question(s) but of course I can't. May I email you a few things and fact based information that at the very least will give you a better understanding or hopefully empower you with some more knowledge.

With your permission first!

Medical Specialist MRI/HR/DIR
21 years & still learning!  (+ info)

how is Wernicke's encephalopathy precipitated after a carbohydrate load in thiamine deficiency?


Wernicke's encephalopathy involves damage to multiple nerves in both the central nervous system (brain and spinal cord) and the peripheral nervous system (the rest of the body).
It may also include symptoms caused by alcohol withdrawal. The cause is generally attributed to malnutrition, especially lack of vitamin B1 (thiamine), which is common in those with alcoholism.
Heavy alcohol use interferes with the break down of thiamine in the body, so even if someone with alcoholism follows a well-balanced diet, most of the thiamine is not absorbed.
Korsakoff syndrome, or Korsakoff psychosis, tends to develop as Wernicke's symptoms do away. This involves damage to areas of the brain involved with memory. Patients often attempt to hide their poor memory by creating detailed, believable stories about experiences or situations. This is not usually a deliberate attempt to deceive because the patient often believes what he is saying to be true.
Please see the web pages for more details on Wernicke's encephalopathy and Wernicke-Korsakoff syndrome  (+ info)

What vitamin deficiency causes bumps and sores at the corners of your mouth?


My 16 month old daughter has small bumps on the inside corner of her mouth and a sore on the outside corner of one lip. Is that a sign of vitamin deficiency. She does not seem bothered by them.
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Could be vitamin B12, but I am not certain.

Top Ten foods highest in vitamin B12:
http://www.healthaliciousness.com/articles/foods-high-in-vitamin-B12.php  (+ info)

What is the deficiency of food causes weight loss due to thyroid disorder?


I am taking methimozole along with multivitimins tablets for thyroid disorder for the last 10 days. I have been prescribed these medicines for two months. In addition to it, what food I should take more to meet the deficiency. I have no other health problem. I am regularly doing physical exercises for the last 10 years. I wonder how it happened? can any expert please explain?
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Hyperthyroidism is characterized by hypermetabolism and elevated serum levels of free thyroid hormones. Symptoms are many but include tachycardia, fatigue, weight loss, and tremor. Diagnosis is clinical and with thyroid function tests. Treatment depends on cause.(Merck)
Major clinical signs of Hyperthyroidism include weight loss (often accompanied by a ravenous appetite), anxiety, intolerance to heat, fatigue, hair loss, weakness, hyperactivity, irritability, apathy, depression, polyuria, polydipsia, and sweating.(Wikipedia)
Methimazole is used to treat hyperthyroidism, a condition that occurs when the thyroid gland produces too much thyroid hormone. It is also taken before thyroid surgery or radioactive iodine therapy.(MedlinePlus)
Methimazole and propylthiouracil are used to treat conditions in which the thyroid gland produces too much thyroid hormone.
These medicines work by making it harder for the body to use iodine to make thyroid hormone. They do not block the effects of thyroid hormone that was made by the body before their use was begun.(MayoClinic).  (+ info)

How does iron deficiency affect the composition of blood?


I have a good friend who is diagnosed with iron deficiency, although she is getting better i want to know more about her sickness. Please answer.
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Iron deficiency makes it harder for your blood to provide oxygen to your body. So you could feel tired or out of breath. It's not that uncommon in women. I think, but do not know, that's it's because they have to replace the menstrual loss every month. There could be other more serious problems causing the deficiency - ask your friend about the diagnosis.

Iron-poor blood is less dense than iron-rich. When you donate blood, they'll put a drop into a special solution to see if it sinks. If it floats, there isn't enough iron. If it sinks like a rock, there's plenty.  (+ info)

What deficiency is it when you see bright dots flying in front of your eyes?


I mean when I are just not exactly looking at anythign in particular but you see bright dots/sparks flying away near your line of vision.

Weird? I thought so.But I figured this is a kind of deficiency.I remembered seeing this during pregnancy.I was anaemic then?Does this mean I am anaemic?

April.
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I thought floaters were usually dark.
My Mom had the sparks once and was told to get to a Dr. to have her eyes checked immediately. Sometimes this is an indication of something happening within your eye. I can't remember for sure but I think it has something to do with the retina separating?
Anyhow....check it out. Perhaps it is more substantial at my mom's age, but it's better to be safe then sorry!
All the best!  (+ info)

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