Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL genes to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as precursor cell lymphoblastic leukemia-lymphoma; leukemia, myelogenous, chronic, bcr-abl positive; and NEUTROPHILIC LEUKEMIA, CHRONIC.

Symptoms and diagnosis



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