A signal transducing adaptor protein that links extracellular signals to the map kinase signaling system. Grb2 associates with activated epidermal growth factor RECEPTOR and platelet-derived growth factor RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the son of sevenless proteins through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).

Symptoms and diagnosis



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