Insomnia, Fatal Familial (Fatal Familial Insomnia)

An autosomal dominant disorder characterized by degeneration of the thalamus and progressive insomnia. It is caused by a mutation in the prion protein (prions).


Images

Idiogram of Chromosome 20 showing gene PRP location

Fatal familial insomnia

Hypnogram showing sleep cycles from midnight to 6:30 am, with deep sleep early on. There is more REM (marked red) before waking. (Current hypnograms reflect the recent decision to combine NREM stages 3 and 4 into a single stage 3.)

Fatal familial insomnia

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Fatal familial insomnia

The human brain. Differences in male and female brain size are relative to body size.

Fatal familial insomnia

Hypermetabolism is one symptom of Astrocytoma. Shown above is a PET scan of hypermetabolic Astrocytoma in the brain.

Hypermetabolism

Diagnosis and therapies

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Symptoms and diagnosis

Symptoms:

    

Wikipedia

Hypermetabolism - Wikipedia

More information

Reported cases - Summary of cases reported on this diseaseWHO - World Health OrganizationPubMed - A service of the National Library of Medicine and National Institutes of HealthMEDLINE - Literature from the National Library of MedicineMeSH - Medical Subject HeadingsDeCS - Health Sciences Descriptors

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