Neuronal Migration Disorders

Disorders resulting from defects in migration of neuronal cells during neurogenesis. Developing nerve cells either fail to migrate or they migrate to incorrect positions resulting in formation of heterotopias, lissencephaly, or other malformations and dysfunctions of the nervous system.


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MRI of a child experiencing seizures. There are small foci of grey matter heterotopia in the corpus callosum, deep to the dysplastic cortex (double arrows)'Gray matter heterotopia' (singular 'heterotopion') is a neurological disorder caused by clumps of grey matter being located in the wrong part of the brain. It is characterized as a type of cortical dysplasia. The neurons in heterotopia appear to be normal, except for their mislocation; nuclear studies have shown glucose metabolism equal to that of normally positioned gray matter.http://www.uhrad.com/mriarc/mri010.htm uhrad.com - Neuroradiology Imaging Teaching Files The condition causes a variety of symptoms, but usually includes some degree of epilepsy or recurring seizures, and often affects the brain's ability to function on higher levels. Symptoms range from nonexistent to profound; the condition is occasionally discovered by brain imaging performed for an unrelated problem and has no apparent ill effect on the patient. At the other extreme, heterotopi

Gray matter heterotopia

The human brain. Differences in male and female brain size are relative to body size.

Gray matter heterotopia

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Gray matter heterotopia

Gray matter heterotopia

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Symptoms and diagnosis

Symptoms:

    

Wikipedia

Bilateral frontoparietal polymicrogyria - WikipediaVLDL receptor - WikipediaNasal glial heterotopia - Wikipedia

More information

Reported cases - Summary of cases reported on this diseaseWHO - World Health OrganizationPubMed - A service of the National Library of Medicine and National Institutes of HealthMEDLINE - Literature from the National Library of MedicineMeSH - Medical Subject HeadingsDeCS - Health Sciences Descriptors
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