A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-coa hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-coa dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by peroxisomal bifunctional enzyme, which has the opposite reaction stereospecificity.


Symptoms and diagnosis

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