Cessation of ovarian function after menarche but before the age of 40, without or with ovarian follicle depletion. It is characterized by the presence of oligomenorrhea or amenorrhea, elevated gonadotropins, and low estradiol levels. It is a state of female HYPERGONADOTROPIC hypogonadism. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections.

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