A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for epidermal growth factor and EGF-related peptides including transforming growth factor alpha; AMPHIREGULIN; and heparin-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.

Symptoms and diagnosis



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