A calcium and calmodulin-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. calcineurin has been shown to dephosphorylate a number of phosphoproteins including histones; MYOSIN light CHAIN; and the regulatory subunits of CAMP-DEPENDENT protein kinases. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.

Symptoms and diagnosis



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