Substances that do not act as agonists or antagonists but do affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors (receptors, gaba-a) appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL anesthetics probably act at least partly by potentiating GABAergic responses, but they are not included here.


Symptoms and diagnosis

Symptoms:

    


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