An abnormal congenital condition, associated with defects in the lamin type a gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (deafness); cataracts (cataract); arthritis; osteoporosis; diabetes mellitus; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary hyaluronic acid; and accelerated atherosclerosis. Many affected individuals develop malignant tumors, especially sarcoma.

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