A regulatory sequence found in the 5' terminal regions of a variety of rna species. The sequence starts with a cytidine, which is followed by a stretch of 5 to 15 pyrimidine nucleotides. Messenger rna that contains the 5' Terminal Oligo Pyrimidine tract is often referred to as 5' TOP mRNA. The sequence acts as a translational regulator and has been found in mRNAs for peptide elongation factors and ribosomal proteins.

Symptoms and diagnosis



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